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rseB anti-sigma factor stabilizing protein RseB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947054, updated on 19-Sep-2024

Summary

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Official Symbol
rseB
Official Full Name
anti-sigma factor stabilizing protein RseB
Primary source
ECOCYC:G7348
Locus tag
b2571
See related
ASAP:ABE-0008459
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2569
Summary
SignalP predicts cleavage of first 23 aa. [More information is available at EcoGene: EG13177]. RseB interacts with RseA, the anti-sigma factor that inhibits sigma E . [More information is available at EcoCyc: G7348].
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Genomic context

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Sequence:
NC_000913.3 (2707798..2708754, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene signal peptidase I Neighboring gene 30S ribosomal subunit biogenesis factor LepA Neighboring gene protein RseC Neighboring gene anti-sigma-E factor RseA Neighboring gene RNA polymerase sigma factor RpoE Neighboring gene rpoE leader peptide Neighboring gene L-aspartate oxidase Neighboring gene tRNA m(6)A37 methyltransferase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The structure of RseB: a sensor in periplasmic stress response of E. coli. Wollmann P, et al. J Mol Biol, 2007 Sep 28. PMID 17692869
  2. Expression, crystallization and preliminary X-ray analysis of the periplasmic stress sensory protein RseB from Escherichia coli. Wollmann P, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Sep 1. PMID 16946473, Free PMC Article
  3. Recognition of β-strand motifs by RseB is required for σ(E) activity in Escherichia coli. Kulp A, et al. J Bacteriol, 2011 Nov. PMID 21908666, Free PMC Article
  4. Structural basis for the negative regulation of bacterial stress response by RseB. Kim DY, et al. Protein Sci, 2010 Jun. PMID 20512978, Free PMC Article
  5. Two stress sensor proteins for the expression of sigmaE regulon: DegS and RseB. Kim DY. J Microbiol, 2015 May. PMID 25935301

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DegS and RseB are proposed to be stress sensor proteins for sigmaE signal transduction [review]
    Title: Two stress sensor proteins for the expression of sigmaE regulon: DegS and RseB.
  2. Recognition of beta-strand motifs of sigma(E) by RseB is required for sigma(E) activity.
    Title: Recognition of β-strand motifs by RseB is required for σ(E) activity in Escherichia coli.
  3. Results show RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response.
    Title: Structural basis for the negative regulation of bacterial stress response by RseB.
  4. Results suggest that RseB acts as a sensor of periplasmic stress with a dual functionality: it detects mislocalized lipoproteins and propagates the signal to induce the sigma(E)-response.
    Title: The structure of RseB: a sensor in periplasmic stress response of E. coli.
  5. Although DegS cleavage of RseA is normally activated by binding of the C termini of porins to the PDZ domain of DegS, RseB inhibition is independent of this activation mechanism
    Title: Inhibition of regulated proteolysis by RseB.
  6. Stress sensory protein RseB from E. coli, missing the periplasmic signal sequence, has been cloned, expressed, purified and crystallized.
    Title: Expression, crystallization and preliminary X-ray analysis of the periplasmic stress sensory protein RseB from Escherichia coli.
  7. two RseAs bind to the grooves of the dimeric RseB by conserved residues
    Title: Crystal structure of RseB and a model of its binding mode to RseA.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables antisigma factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antisigma factor binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of polysaccharide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in outer membrane-bounded periplasmic space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in outer membrane-bounded periplasmic space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in periplasmic space IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of sigma factor antagonist complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
anti-sigma factor stabilizing protein RseB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2707798..2708754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417066.1 anti-sigma factor stabilizing protein RseB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417066.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A826IYV2
    Conserved Domains (1) summary
    PRK09455
    Location:1 → 318
    rseB; anti-sigma E factor; Provisional
Nucleotide Protein
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