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acpS holo-[acyl-carrier-protein] synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947037, updated on 19-Sep-2024

Summary

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Official Symbol
acpS
Official Full Name
holo-[acyl-carrier-protein] synthase
Primary source
ECOCYC:EG10247
Locus tag
b2563
See related
ASAP:ABE-0008433
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
dpj; ECK2561
Summary
acpS(dpj) was demonstrated to be an essential gene (Takiff, 1992), consistent with the results of Baba (2006). [More information is available at EcoGene: EG10247]. The acpS gene encodes holo-[ACP] synthase, which transfers the 4-phosphopantetheine moiety of CoA to the apo-ACP to form holo-ACP, the active form of the carrier in lipid synthesis . [More information is available at EcoCyc: EG10247].
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Genomic context

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Sequence:
NC_000913.3 (2700618..2700998, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene toxic peptide ShoB Neighboring gene ncRNA Neighboring gene pyridoxine 5'-phosphate synthase Neighboring gene recombination mediator protein RecO

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A homogeneous resonance energy transfer assay for phosphopantetheinyl transferase. Foley TL, et al. Anal Biochem, 2009 Nov 1. PMID 19573516, Free PMC Article
  2. Acyl carrier protein synthases from gram-negative, gram-positive, and atypical bacterial species: Biochemical and structural properties and physiological implications. McAllister KA, et al. J Bacteriol, 2006 Jul. PMID 16788183, Free PMC Article
  3. Site-directed mutagenesis of the spinach acyl carrier protein-I prosthetic group attachment site. Jaworski JG, et al. Eur J Biochem, 1989 Oct 1. PMID 2553397
  4. Acyl carrier protein. X. Acyl carrier protein synthetase. Elovson J, et al. J Biol Chem, 1968 Jul 10. PMID 4872726
  5. Evidence that incorporation of exogenous fatty acids into the phospholipids of Escherichia coli does not require acyl carrier protein. Cronan JE Jr. J Bacteriol, 1984 Aug. PMID 6378892, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Cloning, overproduction, and characterization of the Escherichia coli holo-acyl carrier protein synthase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables holo-[acyl-carrier-protein] synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables holo-[acyl-carrier-protein] synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within fatty acid biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
holo-[acyl-carrier-protein] synthase
NP_417058.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2700618..2700998 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417058.1 holo-[acyl-carrier-protein] synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417058.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AQR2
    Conserved Domains (1) summary
    PRK00070
    Location:2 → 126
    acpS; 4'-phosphopantetheinyl transferase; Provisional
Nucleotide Protein
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Other Literature Sources
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Research Materials