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glyA serine hydroxymethyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 947022, updated on 6-Jun-2024

Summary

Gene symbol
glyA
Gene description
serine hydroxymethyltransferase
Primary source
ASAP:ABE-0008389
Locus tag
b2551
See related
ECOCYC:EG10408
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2548
Summary
Serine hydroxymethyltransferase converts serine to glycine, transferring a methyl group to tetrahydrofolate, thus forming 5,10-methylene-tetrahydrofolate (5,10-mTHF). [More information is available at EcoCyc: EG10408].
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Genomic context

Sequence:
NC_000913.3 (2684254..2685507, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF5107 domain-containing protein YphG Neighboring gene putative DNA-binding transcriptional regulator, NAGC-like Neighboring gene nitric oxide dioxygenase Neighboring gene nitrogen regulatory protein PII-1

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables L-allo-threonine aldolase activity IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables glycine hydroxymethyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables glycine hydroxymethyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glycine hydroxymethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables glycine hydroxymethyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane HDA PubMed 

General protein information

Preferred Names
serine hydroxymethyltransferase
NP_417046.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2684254..2685507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417046.1 serine hydroxymethyltransferase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417046.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7T8K8, A0AA87KKC8
    Conserved Domains (1) summary
    PRK00011
    Location:6417
    glyA; serine hydroxymethyltransferase; Reviewed