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hscB [Fe-S] cluster biosynthesis co-chaperone HscB [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946995, updated on 19-Sep-2024

Summary

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Official Symbol
hscB
Official Full Name
[Fe-S] cluster biosynthesis co-chaperone HscB
Primary source
ECOCYC:EG12131
Locus tag
b2527
See related
ASAP:ABE-0008317
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2524; yfhE
Summary
HscB is a co-chaperone that stimulates HscA (Hsc66) ATPase activity . [More information is available at EcoCyc: EG12131].
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Genomic context

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Sequence:
NC_000913.3 (2658952..2659467, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene reduced ferredoxin Neighboring gene iron-sulfur cluster biosynthesis chaperone HscA Neighboring gene iron-sulfur cluster insertion protein IscA Neighboring gene scaffold protein for iron-sulfur cluster assembly

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A New Tessera into the Interactome of the isc Operon: A Novel Interaction between HscB and IscS. Puglisi R, et al. Front Mol Biosci, 2016. PMID 27730125, Free PMC Article
  2. Crystallization and preliminary X-ray crystallographic properties of Hsc20, a J-motif co-chaperone protein from Escherichia coli. Cupp-Vickery JR, et al. Protein Sci, 1997 Sep. PMID 9300502, Free PMC Article
  3. Structure and dynamics of the iron-sulfur cluster assembly scaffold protein IscU and its interaction with the cochaperone HscB. Kim JH, et al. Biochemistry, 2009 Jul 7. PMID 19492851, Free PMC Article
  4. Solution structure of the iron-sulfur cluster cochaperone HscB and its binding surface for the iron-sulfur assembly scaffold protein IscU. Füzéry AK, et al. Biochemistry, 2008 Sep 9. PMID 18702525, Free PMC Article
  5. Hsc66 and Hsc20, a new heat shock cognate molecular chaperone system from Escherichia coli. Vickery LE, et al. Protein Sci, 1997 May. PMID 9144776, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables ATPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in [2Fe-2S] cluster assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in protein complex oligomerization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in protein maturation by iron-sulfur cluster transfer IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein maturation by iron-sulfur cluster transfer IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within protein maturation by iron-sulfur cluster transfer IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of iron-sulfur cluster transfer complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of iron-sulfur cluster transfer complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
[Fe-S] cluster biosynthesis co-chaperone HscB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2658952..2659467 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417022.1 [Fe-S] cluster biosynthesis co-chaperone HscB [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_417022.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A2X1MPV6
    Conserved Domains (1) summary
    PRK05014
    Location:1 → 170
    hscB; co-chaperone HscB; Provisional
Nucleotide Protein
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