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glpA anaerobic glycerol-3-phosphate dehydrogenase subunit A [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946713, updated on 6-Jul-2026
Official Symbol
glpA
Official Full Name
anaerobic glycerol-3-phosphate dehydrogenase subunit A
Primary source
ECOCYC:EG10391
Locus tag
b2241
See related
ASAP:ABE-0007422
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2233
Summary
The GlpABC enzyme is loosely associated with the cell membrane. [More information is available at EcoCyc: EG10391].
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Sequence:
NC_000913.3 (2352647..2354275)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycerophosphoryl diester phosphodiesterase GlpQ Neighboring gene sn-glycerol 3-phosphate:phosphate antiporter Neighboring gene anaerobic glycerol-3-phosphate dehydrogenase subunit B Neighboring gene anaerobic glycerol-3-phosphate dehydrogenase subunit C Neighboring gene inactive recombination-promoting nuclease-like protein RpnE

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Resolution of glpA and glpT loci into separate operons in Escherichia coli K-12 strains. Miki K, et al. J Bacteriol, 1979 Apr. PMID 374371, Free PMC Article
  2. Anaerobic L- -glycerophosphate dehydrogenase of Escherichia coli: its genetic locus and its physiological role. Kistler WS, et al. J Bacteriol, 1971 Dec. PMID 4945192, Free PMC Article
  3. Identification of the glpT-encoded sn-glycerol-3-phosphate permease of Escherichia coli, an oligomeric integral membrane protein. Larson TJ, et al. J Bacteriol, 1982 Dec. PMID 6754693, Free PMC Article
  4. Multiple regulatory elements for the glpA operon encoding anaerobic glycerol-3-phosphate dehydrogenase and the glpD operon encoding aerobic glycerol-3-phosphate dehydrogenase in Escherichia coli: further characterization of respiratory control. Iuchi S, et al. J Bacteriol, 1990 Jan. PMID 2403539, Free PMC Article
  5. Enzyme complex which couples glycerol-3-phosphate dehydrogenation to fumarate reduction in Escherichia coli. Miki K, et al. J Bacteriol, 1973 May. PMID 4574699, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on complete protein
    Title: Nucleotide sequence and gene-polypeptide relationships of the glpABC operon encoding the anaerobic sn-glycerol-3-phosphate dehydrogenase of Escherichia coli K-12.
Submit: New GeneRIF Correction
Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FMN binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables glycerol-3-phosphate dehydrogenase (quinone) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glycerol-3-phosphate dehydrogenase (quinone) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycerol-3-phosphate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (quinone) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anaerobic respiration IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in anaerobic respiration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in glycerol catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glycerol-3-phosphate catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycerol-3-phosphate catabolic process NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in glycerol-3-phosphate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in polyol catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of glycerol-3-phosphate dehydrogenase (FAD) complex IEA
Inferred from Electronic Annotation
more info
  
part_of glycerol-3-phosphate dehydrogenase (FAD) complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
anaerobic glycerol-3-phosphate dehydrogenase subunit A
NP_416744.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2352647..2354275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416744.1 anaerobic glycerol-3-phosphate dehydrogenase subunit A

    See identical proteins and their annotated locations for NP_416744.1

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK11101
    Location:25 → 536
    glpA; anaerobic glycerol-3-phosphate dehydrogenase subunit A
Nucleotide Protein
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