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napC periplasmic nitrate reductase cytochrome c protein [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946706, updated on 19-Sep-2024

Summary

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Official Symbol
napC
Official Full Name
periplasmic nitrate reductase cytochrome c protein
Primary source
ECOCYC:EG12060
Locus tag
b2202
See related
ASAP:ABE-0007281
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2194; yejX
Summary
NapC is essential for electron transfer from both ubiquinol and menaquinol to NapAB. [More information is available at EcoGene: EG12060]. The napC gene encodes a membrane-bound tetraheme cytochrome c protein, which passes electrons either from NapGH or directly from the quinone pool to NapB . [More information is available at EcoCyc: EG12060].
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Genomic context

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Sequence:
NC_000913.3 (2297657..2298259, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome c maturation protein D Neighboring gene cytochrome c maturation protein C Neighboring gene cytochrome c maturation protein B Neighboring gene cytochrome c maturation protein A Neighboring gene periplasmic nitrate reductase cytochrome c550 protein Neighboring gene ferredoxin-type protein NapH Neighboring gene ferredoxin-type protein NapG

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Recombinant nematode anticoagulant protein c2 inhibits cell invasion by decreasing uPA expression in NSCLC cells. Tong Y, et al. Oncol Rep, 2015 Apr. PMID 25672417
  2. Dissimilatory iron reduction in Escherichia coli: identification of CymA of Shewanella oneidensis and NapC of E. coli as ferric reductases. Gescher JS, et al. Mol Microbiol, 2008 May. PMID 18394146
  3. Competition between Escherichia coli strains expressing either a periplasmic or a membrane-bound nitrate reductase: does Nap confer a selective advantage during nitrate-limited growth? Potter LC, et al. Biochem J, 1999 Nov 15. PMID 10548536, Free PMC Article
  4. The molybdate-responsive Escherichia coli ModE transcriptional regulator coordinates periplasmic nitrate reductase (napFDAGHBC) operon expression with nitrate and molybdate availability. McNicholas PM, et al. J Bacteriol, 2002 Jun. PMID 12029041, Free PMC Article
  5. STUDIES ON THE PYRIDINE NUCLEOTIDE SPECIFICITY OF NITRATE REDUCTASE IN HIGHER PLANTS AND ITS RELATIONSHIP TO SULFHYDRYL LEVEL. BEEVERS L, et al. Biochim Biophys Acta, 1964 Sep 18. PMID 14209328

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that rNAPc2 may be a potent agent for the prevention of NSCLC progression.
    Title: Recombinant nematode anticoagulant protein c2 inhibits cell invasion by decreasing uPA expression in NSCLC cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables electron transfer activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in anaerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaerobic respiration IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within anaerobic respiration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in denitrification pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 

General protein information

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Preferred Names
periplasmic nitrate reductase cytochrome c protein
NP_416706.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2297657..2298259 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416706.1 periplasmic nitrate reductase cytochrome c protein [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416706.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A377D097
    Conserved Domains (1) summary
    PRK10617
    Location:1 → 200
    PRK10617; cytochrome c-type protein NapC; Provisional
Nucleotide Protein
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