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dld quinone-dependent D-lactate dehydrogenase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946653, updated on 19-Sep-2024

Summary

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Official Symbol
dld
Official Full Name
quinone-dependent D-lactate dehydrogenase
Primary source
ECOCYC:EG10231
Locus tag
b2133
See related
ASAP:ABE-0007048
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2126; ldh
Summary
There are three lactate dehydrogenase enzymes in Escherichia coli which interconvert pyruvate and lactate. [More information is available at EcoCyc: EG10231].
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Genomic context

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Sequence:
NC_000913.3 (2222185..2223900)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene glycine betaine ABC transporter periplasmic binding protein OsmF Neighboring gene beta-D-glucoside glucohydrolase, periplasmic Neighboring gene peptidoglycan DD-endopeptidase PbpG Neighboring gene putative inner membrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Purification and properties of D-lactate dehydrogenase from Escherichia coli ML 308-225. Kaczorowski G, et al. Methods Enzymol, 1978. PMID 362128
  2. Biochemical and biophysical studies on the interaction of a membrane-bound enzyme, D-lactate dehydrogenase from Escherichia coli, with phospholipids. Fung LW, et al. Biochemistry, 1979 Jan 23. PMID 369600
  3. D- and L-lactic acid oxidases of Escherichia coli. HAUGAARD N. Biochim Biophys Acta, 1959 Jan. PMID 13628604
  4. Inactive and temperature-sensitive folding mutants generated by tryptophan substitutions in the membrane-bound d-lactate dehydrogenase of Escherichia coli. Truong HT, et al. Biochemistry, 1991 Nov 5. PMID 1931992
  5. Overproduction and nucleotide sequence of the respiratory D-lactate dehydrogenase of Escherichia coli. Rule GS, et al. J Bacteriol, 1985 Mar. PMID 3882663, Free PMC Article

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. N-terminus verified by Edman degradation on mature peptide
    Title: Overproduction and nucleotide sequence of the respiratory D-lactate dehydrogenase of Escherichia coli.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables D-lactate dehydrogenase (quinone) activity IEA
Inferred from Electronic Annotation
more info
  
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor IEA
Inferred from Electronic Annotation
more info
  
enables quinone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aerobic respiration IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within anaerobic respiration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in lactate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lactate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within respiratory electron transport chain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in respiratory electron transport chain IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extrinsic component of cytoplasmic side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
quinone-dependent D-lactate dehydrogenase
NP_416637.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2222185..2223900
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416637.1 quinone-dependent D-lactate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416637.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A6N8QX47
    Conserved Domains (1) summary
    PRK11183
    Location:8 → 569
    PRK11183; D-lactate dehydrogenase; Provisional
Nucleotide Protein
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