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mdtC multidrug efflux pump RND permease subunit MdtC [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946608, updated on 2-May-2024

Summary

Gene symbol
mdtC
Gene description
multidrug efflux pump RND permease subunit MdtC
Primary source
ASAP:ABE-0006877
Locus tag
b2076
See related
ECOCYC:G7115
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2072; yegO
Summary
mdtABC overexpression confers resistance to deoxycholate and novobiocin. [More information is available at EcoGene: EG14058]. In response regulator overproduction studies and deletion mutation experiments , the mdtABCD (yegMNOB) genes were found to constitute a multidrug resistance cluster which is regulated by the response regulator BaeR. [More information is available at EcoCyc: G7115].
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Genomic context

Sequence:
NC_000913.3 (2158386..2161463)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump membrane fusion protein MdtA Neighboring gene multidrug efflux pump RND permease subunit MdtB Neighboring gene putative multidrug efflux pump MdtD Neighboring gene sensor histidine kinase BaeS Neighboring gene DNA-binding transcriptional activator BaeR

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables bile acid transmembrane transporter activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables xenobiotic transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of efflux pump complex NAS
Non-traceable Author Statement
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in periplasmic side of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISM
Inferred from Sequence Model
more info
PubMed 

General protein information

Preferred Names
multidrug efflux pump RND permease subunit MdtC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2158386..2161463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416580.1 multidrug efflux pump RND permease subunit MdtC [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416580.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7JW53
    Conserved Domains (1) summary
    PRK10614
    Location:11025
    PRK10614; multidrug efflux system subunit MdtC; Provisional