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ubiG bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946607, updated on 19-Sep-2024

Summary

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Official Symbol
ubiG
Official Full Name
bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase
Primary source
ECOCYC:EG11143
Locus tag
b2232
See related
ASAP:ABE-0007374
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2224; pufX; yfaB
Summary
The ubiG gene product is an O-methyltransferase that catalyzes both O-methylation reactions in the biosynthesis of ubiquinone. [More information is available at EcoCyc: EG11143].
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Genomic context

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Sequence:
NC_000913.3 (2339567..2340289)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1175 domain-containing protein YfaT Neighboring gene DUF2138 domain-containing protein YfaA Neighboring gene DNA gyrase subunit A Neighboring gene putative autotransporter adhesin YfaL Neighboring gene protein YpaB

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli. Sévin DC, et al. Nat Chem Biol, 2014 Apr. PMID 24509820
  2. Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli. Xing L, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Jun 1. PMID 21636923, Free PMC Article
  3. Mutants of Escherichia coli K-12 blocked in the final reaction of ubiquinone biosynthesis: characterization and genetic analysis. Stroobant P, et al. J Bacteriol, 1972 Jan. PMID 4333375, Free PMC Article
  4. Regulation of ubiG gene expression in Escherichia coli. Gibert I, et al. J Bacteriol, 1988 Mar. PMID 2830238, Free PMC Article
  5. Membrane-associated reactions in ubiquinone biosynthesis. 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase. Leppik RA, et al. Biochim Biophys Acta, 1976 Mar 25. PMID 769831

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 2-polyprenyl-6-hydroxyphenol methylase activity IEA
Inferred from Electronic Annotation
more info
  
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3-demethylubiquinol-n 3-O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 3-demethylubiquinol-n 3-O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylglycerol binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within hyperosmotic salinity response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquinone biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane IC
Inferred by Curator
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ubiquinone biosynthesis complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase
NP_416735.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2339567..2340289
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416735.1 bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416735.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EAC5
    Conserved Domains (1) summary
    PRK05134
    Location:9 → 240
    PRK05134; bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG
Nucleotide Protein
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