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wza outer membrane polysaccharide export protein Wza [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946558, updated on 19-Sep-2024

Summary

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Official Symbol
wza
Official Full Name
outer membrane polysaccharide export protein Wza
Primary source
ECOCYC:G7107
Locus tag
b2062
See related
ASAP:ABE-0006825
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2056
Summary
Wza function was initially inferred by analogy with strain K30; now K-12 Wza has been shown to have an identical function. [More information is available at EcoGene: EG13566]. Based on sequence similarity, Wza is a member of the outer membrane auxiliary (OMA) protein family . [More information is available at EcoCyc: G7107].
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Genomic context

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Sequence:
NC_000913.3 (2136104..2137243, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein-tyrosine kinase Wzc Neighboring gene protein-tyrosine phosphatase Neighboring gene inner membrane protein YegH Neighboring gene putative assembly protein AsmA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure-function relationships of the outer membrane translocon Wza investigated by cryo-electron microscopy and mutagenesis. Ford RC, et al. J Struct Biol, 2009 May. PMID 19236919, Free PMC Article
  2. Translocation of group 1 capsular polysaccharide in Escherichia coli serotype K30. Structural and functional analysis of the outer membrane lipoprotein Wza. Nesper J, et al. J Biol Chem, 2003 Dec 12. PMID 14522970
  3. Wza: a new structural paradigm for outer membrane secretory proteins? Collins RF, et al. Trends Microbiol, 2007 Mar. PMID 17275308
  4. Crystallization and preliminary X-ray diffraction analysis of Wza outer-membrane lipoprotein from Escherichia coli serotype O9a:K30. Beis K, et al. Acta Crystallogr D Biol Crystallogr, 2004 Mar. PMID 14993692
  5. Three-dimensional structure of Wza, the protein required for translocation of group 1 capsular polysaccharide across the outer membrane of Escherichia coli. Beis K, et al. J Biol Chem, 2004 Jul 2. PMID 15090537

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables polysaccharide transmembrane transporter activity EXP
Inferred from Experiment
more info
 PubMed 
enables polysaccharide transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables porin activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within colanic acid metabolic process IGC
Inferred from Genomic Context
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in polysaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within polysaccharide transport EXP
Inferred from Experiment
more info
 PubMed 
involved_in polysaccharide transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
part_of pore complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
outer membrane polysaccharide export protein Wza

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    2136104..2137243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416566.1 outer membrane polysaccharide export protein Wza [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416566.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376M7D7
    Conserved Domains (1) summary
    PRK15078
    Location:1 → 379
    PRK15078; polysaccharide export protein Wza; Provisional
Nucleotide Protein
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