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cusC copper/silver export system outer membrane channel [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946288, updated on 4-Feb-2024

Summary

Gene symbol
cusC
Gene description
copper/silver export system outer membrane channel
Primary source
ASAP:ABE-0001958
Locus tag
b0572
See related
ECOCYC:G6320
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0564; ibeB; ylcB
Summary
cusC is in the cusCFBA Cu/Ag efflux operon regulated by Cu and Ag. [More information is available at EcoGene: EG14233]. CusC is an outer membrane factor involved in the detoxification of copper and silver ions in Escherichia coli as part of the CusCFBA copper/silver efflux system. [More information is available at EcoCyc: G6320].
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Genomic context

Sequence:
NC_000913.3 (595600..596973)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene exopolysaccharide secretion system outer membrane protein NfrA Neighboring gene cyclic di-3',5'-guanylate-activated glycosyltransferase Neighboring gene sensor histidine kinase CusS Neighboring gene DNA-binding transcriptional activator CusR Neighboring gene copper/silver export system periplasmic binding protein Neighboring gene copper/silver export system membrane fusion protein

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables copper ion binding IGI
Inferred from Genetic Interaction
more info
PubMed 
enables copper ion transmembrane transporter activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables diacylglycerol binding IDA
Inferred from Direct Assay
more info
PubMed 
enables efflux transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables porin activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within copper ion export IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within copper ion export IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in copper ion export NAS
Non-traceable Author Statement
more info
PubMed 
involved_in copper ion transmembrane transport NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within detoxification of copper ion IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within intracellular copper ion homeostasis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein homotrimerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within response to copper ion IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to copper ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within response to silver ion IEP
Inferred from Expression Pattern
more info
PubMed 
acts_upstream_of_or_within response to silver ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to toxic substance NAS
Non-traceable Author Statement
more info
PubMed 
involved_in silver ion transmembrane transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
 
located_in cell outer membrane RCA
inferred from Reviewed Computational Analysis
more info
PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
part_of pore complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
copper/silver export system outer membrane channel

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    595600..596973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415104.1 copper/silver export system outer membrane channel [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415104.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AA46R5D0
    Conserved Domains (1) summary
    PRK09837
    Location:1457
    PRK09837; Cu(I)/Ag(I) efflux RND transporter outer membrane protein