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lsrR [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 946070, updated on 11-Sep-2024

Summary

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Official Symbol
lsrR
Primary source
ECOCYC:G6799
Locus tag
b1512
See related
ASAP:ABE-0005045
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1505; ydeW
Summary
LsrR is also involved in a DHAP repression of the lsr operon. [More information is available at EcoGene: EG13805]. Using particular analysis and high-throughput analysis (microarrays), it was established that LsrR regulates expression of many genes involved in several processes, such as autoinducer 2 uptake and processing , biofilm architecture , host invasion, stress responses, and foreign DNA, among others . [More information is available at EcoCyc: G6799].
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Genomic context

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Sequence:
NC_000913.3 (1600288..1601241, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene autoinducer-2 kinase Neighboring gene Autoinducer-2 ABC transporter ATP binding subunit Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrC Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrD

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural basis for phosphorylated autoinducer-2 modulation of the oligomerization state of the global transcription regulator LsrR from Escherichia coli. Wu M, et al. J Biol Chem, 2013 May 31. PMID 23589368, Free PMC Article
  2. Escherichia coli autoinducer-2 uptake network does not display hysteretic behavior but AI-2 synthesis rate controls transient bifurcation. Gonzalez Barrios AF, et al. Biosystems, 2010 Jan. PMID 19695305
  3. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. Fuqua WC, et al. J Bacteriol, 1994 Jan. PMID 8288518, Free PMC Article
  4. LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing. Xue T, et al. Cell Res, 2009 Nov. PMID 19636340
  5. AI-3 synthesis is not dependent on luxS in Escherichia coli. Walters M, et al. J Bacteriol, 2006 Aug. PMID 16885435, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA-templated transcription IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription initiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
DNA-binding transcriptional repressor LsrR

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1600288..1601241 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416029.1 DNA-binding transcriptional repressor LsrR [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416029.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7F7W4
    Conserved Domains (1) summary
    PRK15418
    Location:2 → 317
    PRK15418; transcriptional regulator LsrR; Provisional
Nucleotide Protein
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