U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

malY [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945937, updated on 11-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
malY
Primary source
ECOCYC:EG10564
Locus tag
b1622
See related
ASAP:ABE-0005432
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1617
Summary
MalY is a bifunctional protein with a regulatory as well as an enzymatic function. [More information is available at EcoCyc: EG10564].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Sequence:
NC_000913.3 (1700957..1702129)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional repressor MalI Neighboring gene PTS enzyme IIBC component MalX Neighboring gene adenosine deaminase Neighboring gene putative oxidoreductase YdgJ

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Folding pathway of the pyridoxal 5'-phosphate C-S lyase MalY from Escherichia coli. Bertoldi M, et al. Biochem J, 2005 Aug 1. PMID 15823094, Free PMC Article
  2. A proteomic approach to study Escherichia coli. Acetyl esterase interactors unveil a sequence motif involved in protein-protein interaction. D'Ambrosio C, et al. Protein Pept Lett, 2008. PMID 18473943
  3. Trigger enzymes: bifunctional proteins active in metabolism and in controlling gene expression. Commichau FM, et al. Mol Microbiol, 2008 Feb. PMID 18086213
  4. Effect of cysteine desulfhydrase gene disruption on L-cysteine overproduction in Escherichia coli. Awano N, et al. Appl Microbiol Biotechnol, 2003 Aug. PMID 12883870
  5. A new mechanism for the control of a prokaryotic transcriptional regulator: antagonistic binding of positive and negative effectors. Schreiber V, et al. Mol Microbiol, 2000 Feb. PMID 10692154

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables L-cysteine desulfhydrase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-S-conjugate beta-lyase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cysteine-S-conjugate beta-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in methionine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
negative regulator of MalT activity/cystathionine beta-lyase
NP_416139.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1700957..1702129
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_416139.1 negative regulator of MalT activity/cystathionine beta-lyase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_416139.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A8S7EDP5
    Conserved Domains (1) summary
    COG1168
    Location:1 → 390
    MalY; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism, General function prediction only]
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.