U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kdsA 3-deoxy-D-manno-octulosonate 8-phosphate synthase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945785, updated on 4-Feb-2024

Summary

Gene symbol
kdsA
Gene description
3-deoxy-D-manno-octulosonate 8-phosphate synthase
Primary source
ASAP:ABE-0004077
Locus tag
b1215
See related
ECOCYC:EG10518
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1203
Summary
kdsA gutQ double mutants are non-viable and lack KDO; multicopy msbA, or unknown chromsomal mutation(s) in suppressed KDO-null strain KPM22, permit viabilty without KDO-containing LPS (Meredith, 2006). [More information is available at EcoGene: EG10518]. 3-deoxy-D-manno-octulosonate 8-phosphate (KDO-8-P) synthase is a key enzyme in lipopolysaccharide biosynthesis. [More information is available at EcoCyc: EG10518].
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Sequence:
NC_000913.3 (1268165..1269019)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein-(glutamine-N(5)) methyltransferase Neighboring gene SirB family protein YchQ Neighboring gene transglutaminase-like/TPR repeat-containing protein Neighboring gene small toxic polypeptide LdrA Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 3-deoxy-8-phosphooctulonate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables 3-deoxy-8-phosphooctulonate synthase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables 3-deoxy-8-phosphooctulonate synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol HDA PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
3-deoxy-D-manno-octulosonate 8-phosphate synthase
NP_415733.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1268165..1269019
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415733.1 3-deoxy-D-manno-octulosonate 8-phosphate synthase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415733.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A1V2T1J3, A0A2W6PFE8, A0A775X2E9, A0A826Z8Y2
    Conserved Domains (1) summary
    COG2877
    Location:3282
    KdsA; 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell wall/membrane/envelope biogenesis]