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ribD fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945620, updated on 30-Jul-2025
Official Symbol
ribD
Official Full Name
fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase
Primary source
ECOCYC:EG11321
Locus tag
b0414
See related
ASAP:ABE-0001441
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0408; nusII; ribG; ybaE
Summary
The ribD gene encodes a bifunctional enzyme that catalyzes the second (deamination) and third (reduction) steps in the riboflavin biosynthesis pathway. [More information is available at EcoCyc: EG11321].
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Sequence:
NC_000913.3 (433455..434558)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative lipoprotein YajI Neighboring gene NrdR transcriptional repressor Neighboring gene 6,7-dimethyl-8-ribityllumazine synthase Neighboring gene transcription antitermination protein NusB

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Kinetic and mechanistic analysis of the Escherichia coli ribD-encoded bifunctional deaminase-reductase involved in riboflavin biosynthesis. Magalhães ML, et al. Biochemistry, 2008 Jun 17. PMID 18500821
  2. Presence of Escherichia coli of a deaminase and a reductase involved in biosynthesis of riboflavin. Burrows RB, et al. J Bacteriol, 1978 Nov. PMID 30756, Free PMC Article
  3. Insertional disruption of the nusB (ssyB) gene leads to cold-sensitive growth of Escherichia coli and suppression of the secY24 mutation. Taura T, et al. Mol Gen Genet, 1992 Sep. PMID 1406588
  4. NrdR controls differential expression of the Escherichia coli ribonucleotide reductase genes. Torrents E, et al. J Bacteriol, 2007 Jul. PMID 17496099, Free PMC Article
  5. Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis. Richter G, et al. J Bacteriol, 1997 Mar. PMID 9068650, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Products Interactant Other Gene Complex Source Pubs Description

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables 5-amino-6-(5-phosphoribosylamino)uracil reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-amino-6-(5-phosphoribosylamino)uracil reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables diaminohydroxyphosphoribosylaminopyrimidine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diaminohydroxyphosphoribosylaminopyrimidine deaminase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables diaminohydroxyphosphoribosylaminopyrimidine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within riboflavin biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in riboflavin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase
NP_414948.1

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    433455..434558
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414948.1 fused diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase

    See identical proteins and their annotated locations for NP_414948.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A485JIQ4, A0A6N0IHG2, A0A8S7E9V5
    Conserved Domains (1) summary
    PRK10786
    Location:1 → 367
    ribD; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD
Nucleotide Protein
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