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csgG curli secretion channel [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945619, updated on 26-Mar-2025

Summary

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Official Symbol
csgG
Official Full Name
curli secretion channel
Primary source
ECOCYC:G6543
Locus tag
b1037
See related
ASAP:ABE-0003516
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1023
Summary
Overexpression causes abnormal biofilm architecture. [More information is available at EcoGene: EG13413]. CsgG is a lipoprotein located in the outer membrane. [More information is available at EcoCyc: G6543].
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Genomic context

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Sequence:
NC_000913.3 (1100851..1101684, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene chaperone protein YcdY Neighboring gene inner membrane protein YcdZ Neighboring gene curli assembly component CsgF Neighboring gene curli assembly component CsgE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the nonameric bacterial amyloid secretion channel. Cao B, et al. Proc Natl Acad Sci U S A, 2014 Dec 16. PMID 25453093, Free PMC Article
  2. Crystallization and preliminary X-ray crystallographic analysis of the curli transporter CsgG. Goyal P, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Dec. PMID 24316827, Free PMC Article
  3. Spatial clustering of the curlin secretion lipoprotein requires curli fiber assembly. Epstein EA, et al. J Bacteriol, 2009 Jan. PMID 19011034, Free PMC Article
  4. Structural and mechanistic insights into the bacterial amyloid secretion channel CsgG. Goyal P, et al. Nature, 2014 Dec 11. PMID 25219853, Free PMC Article
  5. Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation. Klein RD, et al. mBio, 2018 Jul 17. PMID 30018113, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The secretion of curli subunits depends on a dedicated lipoprotein, CsgG, which is found to form an oligomeric secretion channel in the outer membrane that contains a predicted 16 molecules per asymmetric unit.
    Title: Crystallization and preliminary X-ray crystallographic analysis of the curli transporter CsgG.
  2. The csgFG and crl mutants were deficient in their biofilm formation capabilities and did not form a pellicle at the air-liquid interface.
    Title: Biofilm formation by and multicellular behavior of Escherichia coli O55:H7, an atypical enteropathogenic strain.
  3. Microscopic analysis revealed that CsgG was surface exposed and spatially clustered around curli fibers; curli fiber formation is spatially coordinated with the CsgG assembly apparatus.
    Title: Spatial clustering of the curlin secretion lipoprotein requires curli fiber assembly.
  4. The role of CsgG in curli subunit secretion across the outer membrane was charcterized.
    Title: Secretion of curli fibre subunits is mediated by the outer membrane-localized CsgG protein.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within curli assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in curli assembly NAS
Non-traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within protein secretion by the type VIII secretion system IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein secretion by the type VIII secretion system NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in protein transmembrane transport NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in single-species biofilm formation NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of curli secretion complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of curli secretion complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
curli secretion channel

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1100851..1101684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415555.1 curli secretion channel [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415555.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A5B9AJG2
    Conserved Domains (1) summary
    PRK15184
    Location:1 → 277
    PRK15184; curli production assembly/transport protein CsgG; Provisional
Nucleotide Protein
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