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mltC membrane-bound lytic murein transglycosylase C [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945428, updated on 6-Jul-2026
Official Symbol
mltC
Official Full Name
membrane-bound lytic murein transglycosylase C
Primary source
ECOCYC:G7533
Locus tag
b2963
See related
ASAP:ABE-0009725
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadati; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK2958; yggZ
Summary
MltC should cleave the glycosidic bonds between the N-acetylmuramic acid and N-acetylglucosamine residues in murein. [More information is available at EcoGene: EG12986]. Escherichia coli contains a large number of murein hydrolase enzymes. [More information is available at EcoCyc: G7533].
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Sequence:
NC_000913.3 (3104433..3105512)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene adenine DNA glycosylase Neighboring gene putative Fe(2(+))-trafficking protein Neighboring gene nucleoside:H(+) symporter NupG Neighboring gene constitutive ornithine decarboxylase

Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. Identification of new members of the lytic transglycosylase family in Haemophilus influenzae and Escherichia coli. Dijkstra AJ, et al. Microb Drug Resist, 1996 Spring. PMID 9158737
  2. From growth to autolysis: the murein hydrolases in Escherichia coli. Höltje JV. Arch Microbiol, 1995 Oct. PMID 7487333
  3. Reactions of all Escherichia coli lytic transglycosylases with bacterial cell wall. Lee M, et al. J Am Chem Soc, 2013 Mar 6. PMID 23421439, Free PMC Article
  4. Susceptibility to antibiotics and beta-lactamase induction in murein hydrolase mutants of Escherichia coli. Korsak D, et al. Antimicrob Agents Chemother, 2005 Apr. PMID 15793119, Free PMC Article
  5. SoxRS-regulated expression and genetic analysis of the yggX gene of Escherichia coli. Pomposiello PJ, et al. J Bacteriol, 2003 Nov. PMID 14594836, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables lytic endotransglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan lytic transglycosylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidoglycan lytic transglycosylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell division EXP
Inferred from Experiment
more info
 PubMed 
involved_in cell wall macromolecule catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within cellular response to antibiotic EXP
Inferred from Experiment
more info
 PubMed 
acts_upstream_of_or_within cellular response to oxidative stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within peptidoglycan catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in peptidoglycan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane-bounded periplasmic space TAS
Traceable Author Statement
more info
 PubMed 
Preferred Names
membrane-bound lytic murein transglycosylase C

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    3104433..3105512
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_417438.2 membrane-bound lytic murein transglycosylase C

    See identical proteins and their annotated locations for NP_417438.2

    Status: REVIEWED

    Conserved Domains (1) summary
    PRK11671
    Location:1 → 359
    mltC; membrane-bound lytic murein transglycosylase MltC
Nucleotide Protein
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