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gcl glyoxylate carboligase [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945394, updated on 10-Oct-2024

Summary

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Official Symbol
gcl
Official Full Name
glyoxylate carboligase
Primary source
ECOCYC:EG11583
Locus tag
b0507
See related
ASAP:ABE-0001754
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0500
Summary
Glyoxylate carboligase condenses two molecules of glyoxylate to form tartronate semialdehyde. [More information is available at EcoCyc: EG11583].
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Genomic context

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Sequence:
NC_000913.3 (533916..535697)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene ureidoglycolate lyase Neighboring gene DNA-binding transcriptional repressor AllR Neighboring gene ncRNA Neighboring gene hydroxypyruvate isomerase Neighboring gene tartronate semialdehyde reductase 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Escherichia coli glyoxalate carboligase. Properties and reconstitution with 5-deazaFAD and 1,5-dihydrodeazaFADH2. Cromartie TH, et al. J Biol Chem, 1976 Jan 25. PMID 1107332
  2. Glyoxylate carboligase from E. coli: specificity of the enzyme for unhydrated glyoxylate. Hall RL, et al. Arch Biochem Biophys, 1970 Jun. PMID 4914900
  3. Glyoxylate carboligase of Escherichia coli. Identification of carbon dioxide as the primary reaction product. Hall RL, et al. J Biol Chem, 1969 Aug 10. PMID 4979235
  4. GLYOXYLATE CARBOLIGASE OF ESCHERICHIA COLI: A FLAVOPROTEIN. GUPTA NK, et al. J Biol Chem, 1964 Nov. PMID 14257608
  5. Glyoxylic acid carboligase: an enzyme present in glycolate-grown Escherichia coli. KRAKOW G, et al. J Bacteriol, 1961 Apr. PMID 13753902, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Glyoxylate carboligase thus provides a unique illustration of the fine tuning between catalytic stages imposed during evolution on enzymes catalyzing multistep processes
    Title: Glyoxylate carboligase lacks the canonical active site glutamate of thiamine-dependent enzymes.
  2. N-terminus verified by Edman degradation on mature peptide
    Title: Molecular cloning, DNA sequencing, and biochemical analyses of Escherichia coli glyoxylate carboligase. An enzyme of the acetohydroxy acid synthase-pyruvate oxidase family.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables FAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tartronate-semialdehyde synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tartronate-semialdehyde synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables tartronate-semialdehyde synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables thiamine pyrophosphate binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables thiamine pyrophosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-valine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycolate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glyoxylate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glyoxylate catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in isoleucine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of acetolactate synthase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glyoxylate carboligase
NP_415040.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    533916..535697
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415040.1 glyoxylate carboligase [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415040.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0AAN3IM60, A0AAN3SYQ5
    Conserved Domains (1) summary
    PRK11269
    Location:1 → 587
    PRK11269; glyoxylate carboligase; Provisional
Nucleotide Protein
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