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ompW outer membrane protein W [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 945128, updated on 19-Sep-2024

Summary

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Official Symbol
ompW
Official Full Name
outer membrane protein W
Primary source
ECOCYC:EG11124
Locus tag
b1256
See related
ASAP:ABE-0004210
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK1250; yciD
Summary
OmpW is localized to the cell poles. [More information is available at EcoGene: EG11124]. OmpW is a receptor for Colicin S4 . [More information is available at EcoCyc: EG11124].
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Genomic context

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Sequence:
NC_000913.3 (1314020..1314658)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein Neighboring gene putative inner membrane protein Neighboring gene DUF892 domain-containing protein YciE Neighboring gene DUF892 domain-containing protein YciF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The outer membrane protein OmpW forms an eight-stranded beta-barrel with a hydrophobic channel. Hong H, et al. J Biol Chem, 2006 Mar 17. PMID 16414958
  2. Expression, crystallization and preliminary X-ray crystallographic studies of the outer membrane protein OmpW from Escherichia coli. Albrecht R, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Apr 1. PMID 16582500, Free PMC Article
  3. Outer membrane protein OmpW of Escherichia coli is required for resistance to phagocytosis. Wu XB, et al. Res Microbiol, 2013 Oct. PMID 23811183
  4. Contribution of the outer membrane protein OmpW in Escherichia coli to complement resistance from binding to factor H. Li W, et al. Microb Pathog, 2016 Sep. PMID 27364548
  5. Downregulation of Tsx and OmpW and upregulation of OmpX are required for iron homeostasis in Escherichia coli. Lin XM, et al. J Proteome Res, 2008 Mar. PMID 18220334

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Small multidrug resistance protein EmrE phenotypically associates with OmpW, DcrB and YggM for osmotic stress protection by betaine in Escherichia coli.
    Title: Small multidrug resistance protein EmrE phenotypically associates with OmpW, DcrB and YggM for osmotic stress protection by betaine in Escherichia coli.
  2. Moreover, the binding of Escherichia coli OmpW to human factor H, a major inhibitor of alternative complement pathway, was found, indicating that OmpW recruitment of factor H is a mechanism for bacterial evasion of complement attack.
    Title: Contribution of the outer membrane protein OmpW in Escherichia coli to complement resistance from binding to factor H.
  3. Also, DeltahnsDeltastpA double mutants simultaneously lacking H-NS and its paralog StpA showed more severe reductions in ompW expression at 37 degrees C, resulting in the complete loss of OmpW.
    Title: Expression of the Escherichia coli ompW colicin S4 receptor gene is regulated by temperature and modulated by the H-NS and StpA nucleoid-associated proteins.
  4. These results demonstrated that upregulation of OmpW correlated with increased bacterial survival during phagocytosis.
    Title: Outer membrane protein OmpW of Escherichia coli is required for resistance to phagocytosis.
  5. N-terminus verified by Edman degradation on mature peptide
    Title: Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis.
  6. OmpW forms an eight-stranded beta-barrel with a hydrophobic channel
    Title: The outer membrane protein OmpW forms an eight-stranded beta-barrel with a hydrophobic channel.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell outer membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in outer membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
outer membrane protein W

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    1314020..1314658
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_415772.1 outer membrane protein W [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_415772.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A376JYP2
    Conserved Domains (1) summary
    PRK10959
    Location:1 → 212
    PRK10959; outer membrane protein W; Provisional
Nucleotide Protein
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Gene LinkOut

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