cyoA cytochrome bo3 subunit 2 [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: cyoA
Official Full Name: cytochrome bo3 subunit 2
Primary source: ECOCYC:EG10178
Locus tag: b0432
See related: ASAP:ABE-0001495
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK0426
Summary: 2 IM TMS; cleavable signal peptide can be incorrectly predicted as a third TMS. [More information is available at EcoGene: EG10178]. CyoA is subunit II of the cytochrome bo terminal oxidase complex encoded by cyoABCDE. [More information is available at EcoCyc: EG10178].
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Genomic context

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Sequence:: NC_000913.3 (450663..451610, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

No evidence of low affinity ubiquinone binding site in cytochrome bo3 from Escherichia coli.
Title: Searching for the low affinity ubiquinone binding site in cytochrome bo(3) from Escherichia coli.
Data suggest that in RsCcO(aa3), the E286 mutations severely perturb the active site, while he local structure around E286 in EcQO(bo3) is different, providing a rationale for the different effects of E286 mutations in the two enzymes.
Title: Differential effects of glutamate-286 mutations in the aa(3)-type cytochrome c oxidase from Rhodobacter sphaeroides and the cytochrome bo(3) ubiquinol oxidase from Escherichia coli.
Removal of three terminal cytochrome oxidase genes (cydAB, cyoABCD, and cbdAB) and a quinol monooxygenase gene (ygiN) from the Escherichia coli K-12 MG1655 genome resulted in the activation of ArcA aerobically.
Title: Deletion of genes encoding cytochrome oxidases and quinol monooxygenase blocks the aerobic-anaerobic shift in Escherichia coli K-12 MG1655.
analysis of translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA
Title: Distinct requirements for translocation of the N-tail and C-tail of the Escherichia coli inner membrane protein CyoA.
Data show that the distinct domains of CyoA have different translocation requirements (YidC only and Sec/YidC) and confirms that the membrane biogenesis of subunit II of cytochrome oxidase in bacteria and mitochondria have conserved features.
Title: Membrane biogenesis of subunit II of cytochrome bo oxidase: contrasting requirements for insertion of N-terminal and C-terminal domains.
CyoA is a substrate of a novel pathway that involves both SecYEG and YidC
Title: Subunit a of cytochrome o oxidase requires both YidC and SecYEG for membrane insertion.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables copper ion binding	IEA Inferred from Electronic Annotation more info
enables cytochrome bo3 ubiquinol oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables cytochrome bo3 ubiquinol oxidase activity	IEA Inferred from Electronic Annotation more info
contributes_to cytochrome-c oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytochrome-c oxidase activity	IEA Inferred from Electronic Annotation more info
enables electron transfer activity	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	IEA Inferred from Electronic Annotation more info
enables oxidoreduction-driven active transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables proton transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in ATP synthesis coupled electron transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within aerobic electron transport chain	IDA Inferred from Direct Assay more info	PubMed
involved_in aerobic electron transport chain	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within aerobic respiration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within aerobic respiration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within electron transport coupled proton transport	IDA Inferred from Direct Assay more info	PubMed
involved_in electron transport coupled proton transport	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of cytochrome o ubiquinol oxidase complex	IDA Inferred from Direct Assay more info	PubMed
part_of cytochrome o ubiquinol oxidase complex	IPI Inferred from Physical Interaction more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISM Inferred from Sequence Model more info	PubMed

General protein information

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Preferred Names: cytochrome bo3 subunit 2

NP_414966.1

EC 7.1.1.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

450663..451610 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_414966.1 cytochrome bo3 subunit 2 [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_414966.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A376MCW0

Conserved Domains (1) summary

PRK10525
Location:1 → 315

PRK10525; cytochrome o ubiquinol oxidase subunit II; Provisional