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rof modulator of Rho-dependent transcription termination [ Escherichia coli str. K-12 substr. MG1655 ]

Gene ID: 944891, updated on 19-Sep-2024

Summary

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Official Symbol
rof
Official Full Name
modulator of Rho-dependent transcription termination
Primary source
ECOCYC:G6097
Locus tag
b0189
See related
ASAP:ABE-0000641
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage
Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as
ECK0188; yaeO
Summary
This is the real "mesJ" minE suppressor, not yaeN. [More information is available at EcoGene: EG13221]. Rof interacts with the Rho terminator protein and inhibits binding of RNA to Rho, thus showing antiterminator activity . [More information is available at EcoCyc: G6097].
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Genomic context

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Sequence:
NC_000913.3 (213678..213932, complement)

NC_000913.3Genomic Context describing neighboring genes Neighboring gene VOC domain-containing protein YaeR Neighboring gene tRNA(Ile)-lysidine synthetase Neighboring gene PF06786 family protein YaeP Neighboring gene uncharacterized protein YaeQ Neighboring gene peptidyl-tRNA hydrolase, ribosome rescue factor Neighboring gene sensor lipoprotein NlpE

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Solution structure of YaeO, a Rho-specific inhibitor of transcription termination. Gutiérrez P, et al. J Biol Chem, 2007 Aug 10. PMID 17565995
  2. Identification of Attenuators of Transcriptional Termination: Implications for RNA Regulation in Escherichia coli. Morita T, et al. mBio, 2022 Dec 20. PMID 36226957, Free PMC Article
  3. The Sm-like RNA chaperone Hfq mediates transcription antitermination at Rho-dependent terminators. Rabhi M, et al. EMBO J, 2011 Jun 14. PMID 21673658, Free PMC Article
  4. Participation of Rho-dependent transcription termination in oxidative stress sensitivity caused by an rpoB mutation. Kawamura N, et al. Genes Cells, 2005 May. PMID 15836776
  5. A method for the chemical generation of N-terminal peptide sequence tags for rapid protein identification. Hoving S, et al. Anal Chem, 2000 Mar 1. PMID 10739205

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Identification of Attenuators of Transcriptional Termination: Implications for RNA Regulation in Escherichia coli.
    Title: Identification of Attenuators of Transcriptional Termination: Implications for RNA Regulation in Escherichia coli.
  2. N-terminus verified by Edman degradation on complete protein
    Title: A method for the chemical generation of N-terminal peptide sequence tags for rapid protein identification.
  3. the negative character of YaeO is essential for its function as a Rho-specific inhibitor of transcription termination in vivo, as shown by its solution structure
    Title: Solution structure of YaeO, a Rho-specific inhibitor of transcription termination.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Gene Ontology Provided by EcoCyc

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within regulation of termination of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within transcription antitermination IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
modulator of Rho-dependent transcription termination

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000913.3 Reference assembly

    Range
    213678..213932 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_414731.2 modulator of Rho-dependent transcription termination [Escherichia coli str. K-12 substr. MG1655]

    See identical proteins and their annotated locations for NP_414731.2

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0H3MMH6, A0A148HV81, A0A1X0PPM4, A0A1X0PS29, A0A829L277, A0AAI9IXU3, B1LGZ1, B7MP49, B7N856, B7UJ90, D3GRD4
    Conserved Domains (1) summary
    PRK11625
    Location:1 → 84
    PRK11625; Rho-binding antiterminator; Provisional
Nucleotide Protein
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