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GSTO1 glutathione S-transferase omega 1 [ Homo sapiens (human) ]

Gene ID: 9446, updated on 23-Dec-2018

Summary

Official Symbol
GSTO1provided by HGNC
Official Full Name
glutathione S-transferase omega 1provided by HGNC
Primary source
HGNC:HGNC:13312
See related
Ensembl:ENSG00000148834 MIM:605482
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P28; SPG-R; GSTO 1-1; GSTTLp28; HEL-S-21
Summary
The protein encoded by this gene is an omega class glutathione S-transferase (GST) with glutathione-dependent thiol transferase and dehydroascorbate reductase activities. GSTs are involved in the metabolism of xenobiotics and carcinogens. The encoded protein acts as a homodimer and is found in the cytoplasm. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Expression
Ubiquitous expression in liver (RPKM 91.8), heart (RPKM 47.6) and 25 other tissues See more
Orthologs

Genomic context

See GSTO1 in Genome Data Viewer
Location:
10q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (104254194..104267464)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (106013952..106027222)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 43 Neighboring gene tropomyosin 3 pseudogene Neighboring gene microRNA 609 Neighboring gene microRNA 4482 Neighboring gene glutathione S-transferase omega 2 Neighboring gene inositol 1,4,5-trisphosphate receptor interacting protein Neighboring gene ITPRIP antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Biological oxidations, organism-specific biosystem (from REACTOME)
    Biological oxidations, organism-specific biosystemAll organisms are constantly exposed to foreign chemicals every day. These can be man-made (drugs, industrial chemicals) or natural (alkaloids, toxins from plants and animals). Uptake is usually via ...
  • Chemical carcinogenesis, organism-specific biosystem (from KEGG)
    Chemical carcinogenesis, organism-specific biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
  • Chemical carcinogenesis, conserved biosystem (from KEGG)
    Chemical carcinogenesis, conserved biosystemIt has been estimated that exposure to environmental chemical carcinogens may contribute significantly to the causation of a sizable fraction, perhaps a majority, of human cancers. Human carcinogens ...
  • Drug metabolism - cytochrome P450, organism-specific biosystem (from KEGG)
    Drug metabolism - cytochrome P450, organism-specific biosystem
    Drug metabolism - cytochrome P450
  • Drug metabolism - cytochrome P450, conserved biosystem (from KEGG)
    Drug metabolism - cytochrome P450, conserved biosystem
    Drug metabolism - cytochrome P450
  • Fluid shear stress and atherosclerosis, organism-specific biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, organism-specific biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Fluid shear stress and atherosclerosis, conserved biosystem (from KEGG)
    Fluid shear stress and atherosclerosis, conserved biosystemShear stress represents the frictional force that the flow of blood exerts at the endothelial surface of the vessel wall and plays a central role in vascular biology and contributes to the progress o...
  • Glutathione conjugation, organism-specific biosystem (from REACTOME)
    Glutathione conjugation, organism-specific biosystemGlutathione S-Transferases (GSTs; EC 2.5.1.18) are another major set of phase II conjugation enzymes. They can be found in the cytosol as well as being microsomal membrane-bound. Cytosolic GSTs are e...
  • Glutathione metabolism, organism-specific biosystem (from KEGG)
    Glutathione metabolism, organism-specific biosystem
    Glutathione metabolism
  • Glutathione metabolism, conserved biosystem (from KEGG)
    Glutathione metabolism, conserved biosystem
    Glutathione metabolism
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, classified according to their solubility, either fat-soluble or water-soluble, that are either not synthesized or synthesized only in limited amount...
  • Metabolism of water-soluble vitamins and cofactors, organism-specific biosystem (from REACTOME)
    Metabolism of water-soluble vitamins and cofactors, organism-specific biosystemVitamins are a diverse group of organic compounds, required in small amounts in the diet. They have distinct biochemical roles, often as coenzymes, and are either not synthesized or synthesized only ...
  • Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem (from KEGG)
    Metabolism of xenobiotics by cytochrome P450, organism-specific biosystem
    Metabolism of xenobiotics by cytochrome P450
  • Metabolism of xenobiotics by cytochrome P450, conserved biosystem (from KEGG)
    Metabolism of xenobiotics by cytochrome P450, conserved biosystem
    Metabolism of xenobiotics by cytochrome P450
  • Metapathway biotransformation, organism-specific biosystem (from WikiPathways)
    Metapathway biotransformation, organism-specific biosystem
    Metapathway biotransformation
  • Methylation, organism-specific biosystem (from REACTOME)
    Methylation, organism-specific biosystemMethylation is a common but minor pathway of Phase II conjugation compared to glucuronidation or sulfonation. The cofactor used in methylation conjugation is S-adenosylmethionine (SAM). SAM is the ...
  • Myometrial Relaxation and Contraction Pathways, organism-specific biosystem (from WikiPathways)
    Myometrial Relaxation and Contraction Pathways, organism-specific biosystemThis pathway illustrates signaling networks implicated in uterine muscle contraction at labor and quiescence throughout gestation (pregnancy). The muscle of the uterus, responsible for contractile ac...
  • Phase II conjugation, organism-specific biosystem (from REACTOME)
    Phase II conjugation, organism-specific biosystemPhase II of biotransformation is concerned with conjugation, that is using groups from cofactors to react with functional groups present or introduced from phase I on the compound. The enzymes involv...
  • Platinum drug resistance, organism-specific biosystem (from KEGG)
    Platinum drug resistance, organism-specific biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
  • Platinum drug resistance, conserved biosystem (from KEGG)
    Platinum drug resistance, conserved biosystemPlatinum-based drugs cisplatin, carboplatin and oxaliplatin are widely used in the therapy of solid malignancies, including testicular, ovarian, head and neck, colorectal, bladder and lung cancers. T...
  • Vitamin C (ascorbate) metabolism, organism-specific biosystem (from REACTOME)
    Vitamin C (ascorbate) metabolism, organism-specific biosystemVitamin C (ascorbate) is an antioxidant and a cofactor in reactions catalyzed by Cu+-dependent monooxygenases and Fe++-dependent dioxygenases. Many mammals can synthesize ascorbate de novo; humans an...
  • arsenate detoxification I (glutaredoxin), organism-specific biosystem (from BIOCYC)
    arsenate detoxification I (glutaredoxin), organism-specific biosystemGeneral Background While the jury is still out about whether Napoleon Bonaparte died of arsenic poisoning or cancer , it is agreed by all that arsenic is a potent toxicant. Indeed, the results of ex...
  • arsenate detoxification I (glutaredoxin), conserved biosystem (from BIOCYC)
    arsenate detoxification I (glutaredoxin), conserved biosystemGeneral Background While the jury is still out about whether Napoleon Bonaparte died of arsenic poisoning or cancer |CITS: [367316] [6750413]|, it is agreed by all that arsenic is a potent toxicant....
  • ascorbate recycling (cytosolic), organism-specific biosystem (from BIOCYC)
    ascorbate recycling (cytosolic), organism-specific biosystemGeneral Background : ASCORBATE (vitamin C, ascorbic acid) is a reducing agent and water-soluble antioxidant. It can be biosynthesized by plants (see : PWY-882), some bacteria (see : PWY-5521) and m...
  • ascorbate recycling (cytosolic), conserved biosystem (from BIOCYC)
    ascorbate recycling (cytosolic), conserved biosystemGeneral Background |FRAME: ASCORBATE| (vitamin C, ascorbic acid) is a reducing agent and water-soluble antioxidant. It can be biosynthesized by plants (see |FRAME: PWY-882|), some bacteria (see |FR...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp686H13163

Gene Ontology Provided by GOA

Function Evidence Code Pubs
glutathione dehydrogenase (ascorbate) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutathione dehydrogenase (ascorbate) activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
glutathione transferase activity TAS
Traceable Author Statement
more info
 
methylarsonate reductase activity TAS
Traceable Author Statement
more info
 
oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 

General protein information

Preferred Names
glutathione S-transferase omega-1
Names
MMA(V) reductase
S-(Phenacyl)glutathione reductase
epididymis secretory protein Li 21
glutathione S-transferase omega 1-1
glutathione-S-transferase like
glutathione-dependent dehydroascorbate reductase
monomethylarsonic acid reductase
NP_001177931.1
NP_001177932.1
NP_004823.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023362.1 RefSeqGene

    Range
    5001..18271
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001191002.1NP_001177931.1  glutathione S-transferase omega-1 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    CA431506, CN283947, DT220068
    Consensus CDS
    CCDS53572.1
    UniProtKB/Swiss-Prot
    P78417
    Related
    ENSP00000358724.4, ENST00000369710.8
    Conserved Domains (3) summary
    cd03184
    Location:84196
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    COG0625
    Location:26177
    GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
    cd03055
    Location:594
    GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
  2. NM_001191003.1NP_001177932.1  glutathione S-transferase omega-1 isoform 3

    See identical proteins and their annotated locations for NP_001177932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    CA431506, CF130513, DB501888
    Consensus CDS
    CCDS53573.1
    UniProtKB/Swiss-Prot
    P78417
    Related
    ENSP00000441488.1, ENST00000539281.5
    Conserved Domains (3) summary
    PRK10542
    Location:12192
    PRK10542; glutathionine S-transferase; Provisional
    cd03184
    Location:80201
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    cl00388
    Location:166
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
  3. NM_004832.3NP_004823.1  glutathione S-transferase omega-1 isoform 1

    See identical proteins and their annotated locations for NP_004823.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    BX537431
    Consensus CDS
    CCDS7555.1
    UniProtKB/Swiss-Prot
    P78417
    UniProtKB/TrEMBL
    V9HWG9
    Related
    ENSP00000358727.5, ENST00000369713.9
    Conserved Domains (2) summary
    cd03184
    Location:108229
    GST_C_Omega; C-terminal, alpha helical domain of Class Omega Glutathione S-transferases
    cd03055
    Location:594
    GST_N_Omega; GST_N family, Class Omega subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    104254194..104267464
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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