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PPP1R14A protein phosphatase 1 regulatory inhibitor subunit 14A [ Homo sapiens (human) ]

Gene ID: 94274, updated on 1-Jun-2020

Summary

Official Symbol
PPP1R14Aprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 14Aprovided by HGNC
Primary source
HGNC:HGNC:14871
See related
Ensembl:ENSG00000167641 MIM:608153
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPI17; CPI-17; PPP1INL
Summary
The protein encoded by this gene belongs to the protein phosphatase 1 (PP1) inhibitor family. This protein is an inhibitor of smooth muscle myosin phosphatase, and has higher inhibitory activity when phosphorylated. Inhibition of myosin phosphatase leads to increased myosin phosphorylation and enhanced smooth muscle contraction. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Sep 2011]
Expression
Broad expression in fat (RPKM 20.4), spleen (RPKM 15.6) and 20 other tissues See more
Orthologs

Genomic context

See PPP1R14A in Genome Data Viewer
Location:
19q13.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (38251237..38256374, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38741877..38747231, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene signal induced proliferation associated 1 like 3 Neighboring gene RNA, 7SL, cytoplasmic 663, pseudogene Neighboring gene double PHD fingers 1 Neighboring gene serine peptidase inhibitor, Kunitz type 2 Neighboring gene chromosome 19 open reading frame 33 Neighboring gene Yip1 interacting factor homolog B, membrane trafficking protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein serine/threonine phosphatase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular response to drug IEA
Inferred from Electronic Annotation
more info
 
negative regulation of phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
regulation of phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
protein phosphatase 1 regulatory subunit 14A
Names
17 kDa PKC-potentiated inhibitory protein of PP1
17-KDa protein
PKC-potentiated inhibitory protein of PP1
protein kinase C-potentiated inhibitor protein of 17 kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243947.2NP_001230876.1  protein phosphatase 1 regulatory subunit 14A isoform 2

    See identical proteins and their annotated locations for NP_001230876.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding exon compared to variant 1. This results in a shorter isoform (2, also known as CPI-17beta) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AB056509
    Consensus CDS
    CCDS58660.1
    UniProtKB/Swiss-Prot
    Q96A00
    Related
    ENSP00000301243.3, ENST00000347262.8
    Conserved Domains (1) summary
    pfam05361
    Location:1104
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor
  2. NM_033256.3NP_150281.1  protein phosphatase 1 regulatory subunit 14A isoform 1

    See identical proteins and their annotated locations for NP_150281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1, also known as CPI-17alpha).
    Source sequence(s)
    AB056508
    Consensus CDS
    CCDS12509.1
    UniProtKB/Swiss-Prot
    Q96A00
    Related
    ENSP00000301242.3, ENST00000301242.9
    Conserved Domains (1) summary
    pfam05361
    Location:1131
    PP1_inhibitor; PKC-activated protein phosphatase-1 inhibitor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    38251237..38256374 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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