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Ubqln4 ubiquilin 4 [ Mus musculus (house mouse) ]

Gene ID: 94232, updated on 12-May-2024

Summary

Official Symbol
Ubqln4provided by MGI
Official Full Name
ubiquilin 4provided by MGI
Primary source
MGI:MGI:2150152
See related
Ensembl:ENSMUSG00000008604 AllianceGenome:MGI:2150152
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A1u; A1Up; UBIN; CIP75
Summary
Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of double-strand break repair via homologous recombination; regulation of cellular catabolic process; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within DNA repair and autophagy. Located in cytosol and endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human UBQLN4 (ubiquilin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 35.7), ovary adult (RPKM 34.6) and 28 other tissues See more
Orthologs
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Genomic context

See Ubqln4 in Genome Data Viewer
Location:
3 F1; 3 38.87 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88460984..88477032)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88553677..88569725)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene RAB25, member RAS oncogene family Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88356947-88357056 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 Neighboring gene STARR-positive B cell enhancer ABC_E8803 Neighboring gene STARR-seq mESC enhancer starr_08200 Neighboring gene STARR-seq mESC enhancer starr_08201 Neighboring gene RNA transcription, translation and transport factor, pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6069 Neighboring gene STARR-seq mESC enhancer starr_08203 Neighboring gene signal sequence receptor, beta Neighboring gene STARR-seq mESC enhancer starr_08204

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 
  • Gene trapped (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of cytosolic proteasome complex ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of nuclear proteasome complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in site of DNA damage ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquilin-4
Names
ataxin-1 interacting ubiquitin-like protein
ataxin-1 ubiquitin-like interacting protein
ataxin-1 ubiquitin-like-interacting protein A1U
connexin43-interacting protein of 75 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411427.1NP_001398356.1  ubiquilin-4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC145168
  2. NM_001411428.1NP_001398357.1  ubiquilin-4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC145168
  3. NM_001411430.1NP_001398359.1  ubiquilin-4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC145168
  4. NM_001411431.1NP_001398360.1  ubiquilin-4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC145168
  5. NM_033526.3NP_277068.1  ubiquilin-4 isoform 1

    See identical proteins and their annotated locations for NP_277068.1

    Status: VALIDATED

    Source sequence(s)
    AC145168
    Consensus CDS
    CCDS17479.1
    UniProtKB/Swiss-Prot
    Q8BP88, Q99NB8
    Related
    ENSMUSP00000008748.7, ENSMUST00000008748.8
    Conserved Domains (4) summary
    smart00727
    Location:187224
    STI1; Heat shock chaperonin-binding motif
    cd01808
    Location:1383
    hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2
    smart00213
    Location:1383
    UBQ; Ubiquitin homologues
    cd14399
    Location:553592
    UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    88460984..88477032
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941417.1 RNA Sequence