Ubqln4 ubiquilin 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ubqln4provided by MGI
Official Full Name: ubiquilin 4provided by MGI
Primary source: MGI:MGI:2150152
See related: Ensembl:ENSMUSG00000008604 AllianceGenome:MGI:2150152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: A1u; A1Up; UBIN; CIP75
Summary: Predicted to enable K48-linked polyubiquitin modification-dependent protein binding activity and identical protein binding activity. Predicted to be involved in several processes, including negative regulation of double-strand break repair via homologous recombination; regulation of cellular catabolic process; and ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within DNA repair and autophagy. Located in cytosol and endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human UBQLN4 (ubiquilin 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in adrenal adult (RPKM 35.7), ovary adult (RPKM 34.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3; 3 F1

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (88460984..88477032)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (88553677..88569725)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

UBQLN4 recognizes not only the defective model substrate but also a pool of endogenous defective proteins that were induced by the depletion of the SRP54 subunit of the signal recognition particle.
Title: UBQLN4 recognizes mislocalized transmembrane domain proteins and targets these to proteasomal degradation.
although CIP75 can interact with ubiquitinated cellular proteins, its interaction with Cx43 and stimulation of Cx43 proteasomal degradation does not require the ubiquitination of Cx43.
Title: Ubiquitin-independent proteasomal degradation of endoplasmic reticulum-localized connexin43 mediated by CIP75.
A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43
Title: A novel connexin43-interacting protein, CIP75, which belongs to the UbL-UBA protein family, regulates the turnover of connexin43.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Homologs of the Ubqln4 gene: The Ubqln4 gene is conserved in human, chimpanzee, dog, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 336 organisms have orthologs with human gene Ubqln4
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables K48-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagosome maturation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of double-strand break repair via homologous recombination	ISO Inferred from Sequence Orthology more info
involved_in regulation of proteasomal ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in autophagosome	ISO Inferred from Sequence Orthology more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of cytosolic proteasome complex	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
part_of nuclear proteasome complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ubiquilin-4

Names: ataxin-1 interacting ubiquitin-like protein; ataxin-1 ubiquitin-like interacting protein; ataxin-1 ubiquitin-like-interacting protein A1U; connexin43-interacting protein of 75 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001411427.1 → NP_001398356.1 ubiquilin-4 isoform 2

Status: VALIDATED

Source sequence(s)

AC145168
NM_001411428.1 → NP_001398357.1 ubiquilin-4 isoform 3

Status: VALIDATED

Source sequence(s)

AC145168
NM_001411430.1 → NP_001398359.1 ubiquilin-4 isoform 3

Status: VALIDATED

Source sequence(s)

AC145168
NM_001411431.1 → NP_001398360.1 ubiquilin-4 isoform 3

Status: VALIDATED

Source sequence(s)

AC145168
NM_033526.3 → NP_277068.1 ubiquilin-4 isoform 1

See identical proteins and their annotated locations for NP_277068.1

Status: VALIDATED

Source sequence(s)

AC145168

Consensus CDS

CCDS17479.1

UniProtKB/Swiss-Prot

Q8BP88, Q99NB8

Related

ENSMUSP00000008748.7, ENSMUST00000008748.8

Conserved Domains (4) summary

smart00727
Location:187 → 224

STI1; Heat shock chaperonin-binding motif

cd01808
Location:13 → 83

hPLIC_N; Ubiquitin-like domain of hPLIC-1 and hPLIC2

smart00213
Location:13 → 83

UBQ; Ubiquitin homologues

cd14399
Location:553 → 592

UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

88460984..88477032

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006502396.4 → XP_006502459.1 ubiquilin-4 isoform X1

Conserved Domains (4) summary

PRK11855
Location:55 → 132

PRK11855; dihydrolipoamide acetyltransferase; Reviewed

cd14399
Location:500 → 539

UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

cd01808
Location:11 → 83

Ubl_PLICs; ubiquitin-like (Ubl) domain found in eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

cl17974
Location:187 → 235

STI1; STI1 domain
XM_030252929.2 → XP_030108789.1 ubiquilin-4 isoform X2

Conserved Domains (3) summary

cd14399
Location:380 → 419

UBA_PLICs; UBA domain of eukaryotic protein linking integrin-associated protein (IAP, also known as CD47) with cytoskeleton (PLIC) proteins

pfam17061
Location:309 → 348

PARM

cl17974
Location:44 → 88

STI1; STI1 domain