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Srd5a2 steroid 5 alpha-reductase 2 [ Mus musculus (house mouse) ]

Gene ID: 94224, updated on 24-Apr-2022

Summary

Official Symbol
Srd5a2provided by MGI
Official Full Name
steroid 5 alpha-reductase 2provided by MGI
Primary source
MGI:MGI:2150380
See related
Ensembl:ENSMUSG00000038541 AllianceGenome:MGI:2150380
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5ART2; S5AR 2
Summary
Enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity. Acts upstream of or within androgen biosynthetic process and male genitalia development. Predicted to be located in cell body fiber; cytoplasm; and neuronal cell body. Is expressed in genitourinary system. Human ortholog(s) of this gene implicated in hypospadias and prostate cancer. Orthologous to human SRD5A2 (steroid 5 alpha-reductase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward adrenal adult (RPKM 248.6) See more
Orthologs
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Genomic context

See Srd5a2 in Genome Data Viewer
Location:
17; 17 E2
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (74321886..74354855, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (74014891..74047860, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (74367046..74397256, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30983 Neighboring gene predicted gene, 24475 Neighboring gene predicted gene, 31235 Neighboring gene predicted gene, 53978

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables 3-oxo-5-alpha-steroid 4-dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
enables amide binding ISO
Inferred from Sequence Orthology
more info
 
enables cholestenone 5-alpha-reductase activity IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
enables sterol 5-alpha reductase activity ISO
Inferred from Sequence Orthology
more info
 
enables testosterone dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within androgen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in androgen metabolic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within male genitalia development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male gonad development ISO
Inferred from Sequence Orthology
more info
 
involved_in response to organic substance ISO
Inferred from Sequence Orthology
more info
 
involved_in response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sex differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in steroid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within steroid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in testosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell body fiber ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Names
5 alpha-SR2
SR type 2
steroid 5 alpha reductase type2
NP_444418.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053188.3NP_444418.1  3-oxo-5-alpha-steroid 4-dehydrogenase 2

    See identical proteins and their annotated locations for NP_444418.1

    Status: VALIDATED

    Source sequence(s)
    CT025731
    Consensus CDS
    CCDS28968.1
    UniProtKB/Swiss-Prot
    Q99N99
    Related
    ENSMUSP00000048862.8, ENSMUST00000043458.9
    Conserved Domains (1) summary
    pfam02544
    Location:105254
    Steroid_dh; 3-oxo-5-alpha-steroid 4-dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    74321886..74354855 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)