Format

Send to:

Choose Destination

Srd5a2 steroid 5 alpha-reductase 2 [ Mus musculus (house mouse) ]

Gene ID: 94224, updated on 8-Oct-2018

Summary

Official Symbol
Srd5a2provided by MGI
Official Full Name
steroid 5 alpha-reductase 2provided by MGI
Primary source
MGI:MGI:2150380
See related
Ensembl:ENSMUSG00000038541
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
5ART2; S5AR 2
Expression
Restricted expression toward adrenal adult (RPKM 248.6) See more
Orthologs

Genomic context

See Srd5a2 in Genome Data Viewer
Location:
17; 17 E2
Exon count:
5
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (74017706..74047916, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (74367046..74397256, complement)

Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene xanthine dehydrogenase Neighboring gene predicted gene, 18068 Neighboring gene predicted gene, 30983 Neighboring gene predicted gene, 31084 Neighboring gene predicted gene, 31235

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3-oxo-5-alpha-steroid 4-dehydrogenase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
3-oxo-5-alpha-steroid 4-dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
 
amide binding ISO
Inferred from Sequence Orthology
more info
 
cholestenone 5-alpha-reductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
sterol 5-alpha reductase activity ISO
Inferred from Sequence Orthology
more info
 
testosterone dehydrogenase [NAD(P)] activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
androgen biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
androgen biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
androgen metabolic process ISO
Inferred from Sequence Orthology
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
male genitalia development IMP
Inferred from Mutant Phenotype
more info
PubMed 
male gonad development ISO
Inferred from Sequence Orthology
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
response to organic substance ISO
Inferred from Sequence Orthology
more info
 
response to peptide hormone ISO
Inferred from Sequence Orthology
more info
 
sex differentiation IEA
Inferred from Electronic Annotation
more info
 
steroid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
steroid biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
steroid catabolic process ISO
Inferred from Sequence Orthology
more info
 
steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
testosterone biosynthetic process ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cell body fiber ISO
Inferred from Sequence Orthology
more info
 
cytoplasm ISO
Inferred from Sequence Orthology
more info
 
endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
3-oxo-5-alpha-steroid 4-dehydrogenase 2
Names
5 alpha-SR2
SR type 2
steroid 5 alpha reductase type2
NP_444418.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053188.2NP_444418.1  3-oxo-5-alpha-steroid 4-dehydrogenase 2

    See identical proteins and their annotated locations for NP_444418.1

    Status: VALIDATED

    Source sequence(s)
    CT025731
    Consensus CDS
    CCDS28968.1
    UniProtKB/Swiss-Prot
    Q99N99
    Related
    ENSMUSP00000048862.7, ENSMUST00000043458.8
    Conserved Domains (1) summary
    pfam02544
    Location:105254
    Steroid_dh; 3-oxo-5-alpha-steroid 4-dehydrogenase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

    Range
    74017706..74047916 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center