Format

Send to:

Choose Destination

ABCC12 ATP binding cassette subfamily C member 12 [ Homo sapiens (human) ]

Gene ID: 94160, updated on 23-Nov-2021

Summary

Official Symbol
ABCC12provided by HGNC
Official Full Name
ATP binding cassette subfamily C member 12provided by HGNC
Primary source
HGNC:HGNC:14640
See related
Ensembl:ENSG00000140798 MIM:607041
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MRP9
Summary
This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward testis (RPKM 3.1) See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ABCC12 in Genome Data Viewer
Location:
16q12.1
Exon count:
31
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (48080882..48155993, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (48116884..48180681, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371237 Neighboring gene long intergenic non-protein coding RNA 2134 Neighboring gene ATP binding cassette subfamily C member 11 Neighboring gene lon peptidase 2, peroxisomal Neighboring gene Sharpr-MPRA regulatory region 13528

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study combining pathway analysis for typical sporadic amyotrophic lateral sclerosis in Chinese Han populations.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC27071

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
 
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
ATP-binding cassette sub-family C member 12
Names
ATP-binding cassette transporter sub-family C member 12
ATP-binding cassette, sub-family C (CFTR/MRP), member 12
multidrug resistance-associated protein 9

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001392028.1NP_001378957.1  ATP-binding cassette sub-family C member 12 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC096996
    Related
    ENST00000528693.5
    Conserved Domains (2) summary
    cd18592
    Location:125411
    ABC_6TM_MRP5_8_9_D1; Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated proteins (MRPs) 5, 8, and 9
    cl38936
    Location:486571
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001393797.1NP_001380726.1  ATP-binding cassette sub-family C member 12 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC096996
    Conserved Domains (1) summary
    TIGR00957
    Location:431344
    MRP_assoc_pro; multi drug resistance-associated protein (MRP)
  3. NM_001393798.1NP_001380727.1  ATP-binding cassette sub-family C member 12 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC096996
    Conserved Domains (1) summary
    cd03244
    Location:1181
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
  4. NM_001393799.1NP_001380728.1  ATP-binding cassette sub-family C member 12 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC096996
    Conserved Domains (1) summary
    cd03244
    Location:1212
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
  5. NM_033226.3NP_150229.2  ATP-binding cassette sub-family C member 12 isoform 1

    See identical proteins and their annotated locations for NP_150229.2

    Status: REVIEWED

    Source sequence(s)
    AC096996
    Consensus CDS
    CCDS10730.1
    UniProtKB/Swiss-Prot
    Q96J65
    Related
    ENSP00000311030.3, ENST00000311303.7
    Conserved Domains (4) summary
    cd03244
    Location:11181338
    ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein
    cd03250
    Location:486678
    ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
    TIGR01271
    Location:441336
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    cl00549
    Location:7991070
    ABC_membrane; ABC transporter transmembrane region

RNA

  1. NR_171628.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC096996
  2. NR_171629.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC096996
  3. NR_171630.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC096996
  4. NR_171631.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC096996
  5. NR_171632.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC096996
  6. NR_171633.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC096996
  7. NR_171634.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC096996
  8. NR_171635.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC096996

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    48080882..48155993 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145187.1: Suppressed sequence

    Description
    NM_145187.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate and it is not supported by current protein homology data.
  2. NM_145188.1: Suppressed sequence

    Description
    NM_145188.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate and it is not supported by current protein homology data.
  3. NM_145189.1: Suppressed sequence

    Description
    NM_145189.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate and it is not supported by current protein homology data.
  4. NM_145190.1: Suppressed sequence

    Description
    NM_145190.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate and it is not supported by current protein homology data.
Support Center