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SYTL4 synaptotagmin like 4 [ Homo sapiens (human) ]

Gene ID: 94121, updated on 6-Sep-2021

Summary

Official Symbol
SYTL4provided by HGNC
Official Full Name
synaptotagmin like 4provided by HGNC
Primary source
HGNC:HGNC:15588
See related
Ensembl:ENSG00000102362 MIM:300723
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLP4
Summary
This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in intracellular membrane trafficking. This protein binds Rab27 and may be involved in inhibiting dense core vesicle exocytosis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Mar 2010]
Expression
Broad expression in ovary (RPKM 19.6), endometrium (RPKM 12.8) and 19 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See SYTL4 in Genome Data Viewer
Location:
Xq22.1
Exon count:
22
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (100671964..100732137, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (99929488..99987108, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373298 Neighboring gene tetraspanin 6 Neighboring gene sushi repeat containing protein X-linked 2 Neighboring gene peptidylprolyl isomerase A pseudogene 89 Neighboring gene RAD21 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40960, DKFZp451P0116

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables neurexin family protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neurexin family protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lysosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multivesicular body sorting pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of insulin secretion IEA
Inferred from Electronic Annotation
more info
 
involved_in plasma membrane repair IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of exocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of plasma membrane repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extrinsic component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in platelet alpha granule membrane TAS
Traceable Author Statement
more info
 
located_in transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
synaptotagmin-like protein 4
Names
exophilin-2
granuphilin-a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016858.2 RefSeqGene

    Range
    5613..62656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001129896.3NP_001123368.1  synaptotagmin-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001123368.1

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Consensus CDS
    CCDS14472.1
    UniProtKB/Swiss-Prot
    Q96C24
    UniProtKB/TrEMBL
    A0A024RCF8, A8K973, Q71SF7
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily
  2. NM_001174068.2NP_001167539.1  synaptotagmin-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001167539.1

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Consensus CDS
    CCDS14472.1
    UniProtKB/Swiss-Prot
    Q96C24
    UniProtKB/TrEMBL
    A0A024RCF8, B2R7R4, Q71SF7
    Related
    ENSP00000276141.6, ENST00000276141.10
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily
  3. NM_001370160.1NP_001357089.1  synaptotagmin-like protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily
  4. NM_001370161.1NP_001357090.1  synaptotagmin-like protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Related
    ENSP00000263033.5, ENST00000263033.9
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily
  5. NM_001370162.1NP_001357091.1  synaptotagmin-like protein 4 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Conserved Domains (4) summary
    cd04020
    Location:496622
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    pfam02318
    Location:8121
    FYVE_2; FYVE-type zinc finger
  6. NM_001370163.1NP_001357092.1  synaptotagmin-like protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily
  7. NM_001370164.1NP_001357093.1  synaptotagmin-like protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily
  8. NM_001370165.1NP_001357094.1  synaptotagmin-like protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily
  9. NM_001370166.1NP_001357095.1  synaptotagmin-like protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily
  10. NM_001370167.1NP_001357096.1  synaptotagmin-like protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily
  11. NM_001370168.1NP_001357097.1  synaptotagmin-like protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily
  12. NM_001370169.1NP_001357098.1  synaptotagmin-like protein 4 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily
  13. NM_080737.3NP_542775.2  synaptotagmin-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_542775.2

    Status: REVIEWED

    Source sequence(s)
    AL390040
    Consensus CDS
    CCDS14472.1
    UniProtKB/Swiss-Prot
    Q96C24
    UniProtKB/TrEMBL
    A0A024RCF8, Q71SF7
    Related
    ENSP00000362080.1, ENST00000372989.5
    Conserved Domains (4) summary
    cd04020
    Location:496661
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    cl22851
    Location:8121
    PHD_SF; PHD finger superfamily

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    100671964..100732137 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017029967.2XP_016885456.1  synaptotagmin-like protein 4 isoform X1

    Conserved Domains (4) summary
    cd04020
    Location:496622
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    pfam02318
    Location:8121
    FYVE_2; FYVE-type zinc finger
  2. XM_017029966.1XP_016885455.1  synaptotagmin-like protein 4 isoform X1

    Conserved Domains (4) summary
    cd04020
    Location:496622
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    pfam02318
    Location:8121
    FYVE_2; FYVE-type zinc finger
  3. XM_017029968.1XP_016885457.1  synaptotagmin-like protein 4 isoform X1

    Conserved Domains (4) summary
    cd04020
    Location:496622
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    pfam02318
    Location:8121
    FYVE_2; FYVE-type zinc finger
  4. XM_017029969.1XP_016885458.1  synaptotagmin-like protein 4 isoform X1

    Conserved Domains (4) summary
    cd04020
    Location:496622
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    pfam02318
    Location:8121
    FYVE_2; FYVE-type zinc finger
  5. XM_017029970.1XP_016885459.1  synaptotagmin-like protein 4 isoform X1

    Conserved Domains (4) summary
    cd04020
    Location:496622
    C2B_SLP_1-2-3-4; C2 domain second repeat present in Synaptotagmin-like proteins 1-4
    cd04029
    Location:357481
    C2A_SLP-4_5; C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
    cd15764
    Location:58107
    FYVE_Slp4; FYVE-related domain found in synaptotagmin-like protein 4 (Slp4) and similar proteins
    pfam02318
    Location:8121
    FYVE_2; FYVE-type zinc finger
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