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Mrpl3 mitochondrial ribosomal protein L3 [ Mus musculus (house mouse) ]

Gene ID: 94062, updated on 12-May-2024

Summary

Official Symbol
Mrpl3provided by MGI
Official Full Name
mitochondrial ribosomal protein L3provided by MGI
Primary source
MGI:MGI:2137204
See related
Ensembl:ENSMUSG00000032563 AllianceGenome:MGI:2137204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
dcr; L3mt; 2010320L16Rik; 5930422H18Rik
Summary
Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; genitourinary system; liver; lung; and spleen. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 9. Orthologous to human MRPL3 (mitochondrial ribosomal protein L3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 15.7), placenta adult (RPKM 13.8) and 28 other tissues See more
Orthologs
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Genomic context

See Mrpl3 in Genome Data Viewer
Location:
9; 9 F1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (104930394..104954665)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (105053268..105077466)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57490 Neighboring gene copine IV Neighboring gene STARR-seq mESC enhancer starr_25118 Neighboring gene STARR-seq mESC enhancer starr_25120 Neighboring gene STARR-seq mESC enhancer starr_25121 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:105003152-105003421 Neighboring gene STARR-positive B cell enhancer ABC_E5099 Neighboring gene nudix hydrolase 16 like 2 Neighboring gene nudix hydrolase 16

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Spontaneous (1)  1 citation
  • Targeted (3) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in mitochondrial translation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within translation ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in mitochondrial inner membrane NAS
Non-traceable Author Statement
more info
PubMed 
part_of mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial large ribosomal subunit NAS
Non-traceable Author Statement
more info
PubMed 
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
 
located_in ribosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
large ribosomal subunit protein uL3m
Names
39S ribosomal protein L3, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364512.1NP_001351441.1  large ribosomal subunit protein uL3m isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC117688
    UniProtKB/TrEMBL
    Q05DC5
    Conserved Domains (1) summary
    cl00324
    Location:1235
    Ribosomal_L3; Ribosomal protein L3
  2. NM_001364513.1NP_001351442.1  large ribosomal subunit protein uL3m isoform 3

    Status: VALIDATED

    Source sequence(s)
    AK008592, AK054185
    Consensus CDS
    CCDS90652.1
    UniProtKB/TrEMBL
    D3Z456, Q91XB2
    Related
    ENSMUSP00000117547.2, ENSMUST00000149243.8
    Conserved Domains (1) summary
    cl00324
    Location:3299
    Ribosomal_L3; Ribosomal protein L3
  3. NM_053159.4NP_444389.2  large ribosomal subunit protein uL3m isoform 1

    See identical proteins and their annotated locations for NP_444389.2

    Status: VALIDATED

    Source sequence(s)
    AC117688
    Consensus CDS
    CCDS23462.1
    UniProtKB/Swiss-Prot
    Q3TF66, Q99N95, Q9CVE4
    UniProtKB/TrEMBL
    Q91XB2
    Related
    ENSMUSP00000035177.9, ENSMUST00000035177.15
    Conserved Domains (2) summary
    TIGR03625
    Location:98300
    L3_bact; 50S ribosomal protein uL3, bacterial form
    pfam00297
    Location:2340
    Ribosomal_L3; Ribosomal protein L3

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    104930394..104954665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155424.1XP_036011317.1  large ribosomal subunit protein uL3m isoform X1

    Conserved Domains (1) summary
    pfam00297
    Location:3210
    Ribosomal_L3; Ribosomal protein L3