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STOML1 stomatin like 1 [ Homo sapiens (human) ]

Gene ID: 9399, updated on 11-Jun-2021

Summary

Official Symbol
STOML1provided by HGNC
Official Full Name
stomatin like 1provided by HGNC
Primary source
HGNC:HGNC:14560
See related
Ensembl:ENSG00000067221 MIM:608326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLP-1; STORP; hUNC-24
Expression
Ubiquitous expression in brain (RPKM 7.6), thyroid (RPKM 3.3) and 25 other tissues See more
Orthologs
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Genomic context

See STOML1 in Genome Data Viewer
Location:
15q24.1
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (73978926..73994636, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (74271267..74286963, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene TBC1 domain family member 21 Neighboring gene LOXL1 antisense RNA 1 Neighboring gene lysyl oxidase like 1 Neighboring gene PML nuclear body scaffold Neighboring gene dynamin 1 pseudogene 33

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ36370

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
stomatin-like protein 1
Names
EPB72-like 1
EPB72-like protein 1
protein unc-24 homolog
stomatin (EBP72)-like 1
stomatin (EPB72)-like 1
stomatin-related protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256672.2NP_001243601.1  stomatin-like protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001243601.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC108137, AF156557, AK222665, AK302051, AL109665
    UniProtKB/Swiss-Prot
    Q9UBI4
    UniProtKB/TrEMBL
    Q53HB6
    Conserved Domains (3) summary
    smart00244
    Location:77217
    PHB; prohibitin homologues
    cd13436
    Location:94224
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:303394
    SCP2; SCP-2 sterol transfer family
  2. NM_001256673.1NP_001243602.1  stomatin-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001243602.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF156557, AK302051
    Consensus CDS
    CCDS58384.1
    UniProtKB/Swiss-Prot
    Q9UBI4
    Related
    ENSP00000319384.6, ENST00000316911.10
    Conserved Domains (3) summary
    smart00244
    Location:83167
    PHB; prohibitin homologues
    pfam02036
    Location:254345
    SCP2; SCP-2 sterol transfer family
    cl19107
    Location:79174
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  3. NM_001256674.2NP_001243603.1  stomatin-like protein 1 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon and uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AC108137, AF156557, AK302051, AL109664
    Consensus CDS
    CCDS58383.1
    UniProtKB/Swiss-Prot
    Q9UBI4
    Related
    ENSP00000456343.1, ENST00000564777.5
    Conserved Domains (3) summary
    smart00244
    Location:83167
    PHB; prohibitin homologues
    pfam02036
    Location:253344
    SCP2; SCP-2 sterol transfer family
    cl19107
    Location:79174
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  4. NM_001256675.2NP_001243604.1  stomatin-like protein 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an exon in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (5) is shorter than isoform 1.
    Source sequence(s)
    AC108137, AF156557, AK302051, DQ064605
    Consensus CDS
    CCDS58385.1
    UniProtKB/Swiss-Prot
    Q9UBI4
    Related
    ENSP00000352788.4, ENST00000359750.8
    Conserved Domains (3) summary
    smart00244
    Location:77217
    PHB; prohibitin homologues
    cd13436
    Location:94224
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:264324
    SCP2; SCP-2 sterol transfer family
  5. NM_001256676.1NP_001243605.1  stomatin-like protein 1 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, initiates translation at a downstream, in-frame start codon and uses an alternate in-frame splice site in the coding region, compared to variant 1. The encoded isoform (6) is shorter than isoform 1.
    Source sequence(s)
    AK302051, AL109665, AL533460, BX464941
    Consensus CDS
    CCDS58381.1
    UniProtKB/Swiss-Prot
    Q9UBI4
    UniProtKB/TrEMBL
    H3BST3
    Related
    ENSP00000456853.1, ENST00000561656.5
    Conserved Domains (4) summary
    smart00244
    Location:1130
    PHB; prohibitin homologues
    cd13436
    Location:7137
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:216307
    SCP2; SCP-2 sterol transfer family
    cl21455
    Location:179251
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  6. NM_001256677.1NP_001243606.1  stomatin-like protein 1 isoform 7

    See identical proteins and their annotated locations for NP_001243606.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) contains an alternate exon in the 5' region, initiates translation at an alternate start codon and uses an alternate in-frame splice site in the coding region, compared to variant 1. the encoded isoform (7) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AF156557, AK300799, AK302051, AL109665
    Consensus CDS
    CCDS58382.1
    UniProtKB/Swiss-Prot
    Q9UBI4
    Related
    ENSP00000319323.6, ENST00000316900.9
    Conserved Domains (4) summary
    smart00244
    Location:35175
    PHB; prohibitin homologues
    cd13436
    Location:52182
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:261352
    SCP2; SCP-2 sterol transfer family
    cl21455
    Location:224296
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  7. NM_001324226.1NP_001311155.1  stomatin-like protein 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC108137
    Conserved Domains (3) summary
    pfam02036
    Location:147238
    SCP2; SCP-2 sterol transfer family
    cl19107
    Location:168
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    cl21455
    Location:110182
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  8. NM_001324227.1NP_001311156.1  stomatin-like protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC108137
    Conserved Domains (4) summary
    smart00244
    Location:1130
    PHB; prohibitin homologues
    cd13436
    Location:7137
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:217308
    SCP2; SCP-2 sterol transfer family
    cl21455
    Location:180252
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  9. NM_001324228.2NP_001311157.1  stomatin-like protein 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC108137
    Conserved Domains (4) summary
    smart00244
    Location:1130
    PHB; prohibitin homologues
    cd13436
    Location:7137
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:217308
    SCP2; SCP-2 sterol transfer family
    cl21455
    Location:180252
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  10. NM_001324229.2NP_001311158.1  stomatin-like protein 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC108137
    Conserved Domains (2) summary
    pfam02036
    Location:148239
    SCP2; SCP-2 sterol transfer family
    cl19107
    Location:168
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
  11. NM_001324230.2NP_001311159.1  stomatin-like protein 1 isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC108137
    Conserved Domains (4) summary
    smart00244
    Location:35175
    PHB; prohibitin homologues
    cd13436
    Location:52182
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:262353
    SCP2; SCP-2 sterol transfer family
    cl21455
    Location:225297
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  12. NM_004809.5NP_004800.2  stomatin-like protein 1 isoform 1

    See identical proteins and their annotated locations for NP_004800.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC108137, AF156557, AK302051
    Consensus CDS
    CCDS10254.1
    UniProtKB/Swiss-Prot
    Q9UBI4
    Related
    ENSP00000442478.2, ENST00000541638.6
    Conserved Domains (3) summary
    smart00244
    Location:77217
    PHB; prohibitin homologues
    cd13436
    Location:94224
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:304395
    SCP2; SCP-2 sterol transfer family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    73978926..73994636 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254792.5XP_005254849.1  stomatin-like protein 1 isoform X1

    Conserved Domains (4) summary
    smart00244
    Location:35175
    PHB; prohibitin homologues
    cd13436
    Location:52182
    SPFH_SLP-1; Stomatin-like protein 1 (SLP-1), a subgroup of the stomatin-like proteins (slipins) family; belonging to the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
    pfam02036
    Location:262353
    SCP2; SCP-2 sterol transfer family
    cl21455
    Location:225297
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. XM_024450109.1XP_024305877.1  stomatin-like protein 1 isoform X2

    Conserved Domains (2) summary
    pfam02036
    Location:148239
    SCP2; SCP-2 sterol transfer family
    cl19107
    Location:168
    SPFH_like; core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily
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