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ldeG hydroxymethylglutaryl-CoA lyase (leucine degradation) [ Bacillus subtilis subsp. subtilis str. 168 ]

Gene ID: 939515, updated on 6-Oct-2023

Summary

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Gene symbol
ldeG
Gene description
hydroxymethylglutaryl-CoA lyase (leucine degradation)
Locus tag
BSU_18230
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bacillus subtilis subsp. subtilis str. 168 (strain: 168, sub-species: subtilis, type-material: type strain of Bacillus subtilis)
Lineage
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus
Old locus tag
BSU18230
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Genomic context

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Sequence:
NC_000964.3 (1952031..1952930, complement)

NC_000964.3Genomic Context describing neighboring genes Neighboring gene methylcrotonoyl-CoA carboxylase subunit (leucine degradation) Neighboring gene methylglutaconyl-CoA hydratase (leucine degradation) Neighboring gene methylcrotonyl-CoA carboxylase; biotinylated subunit (leucine degradation) Neighboring gene biotin carboxylase for subunit LdeHB of methylcrotonyl-CoA carboxylase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_000964.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds. Forouhar F, et al. J Biol Chem, 2006 Mar 17. PMID 16330546
  2. Bacillus subtilis, the model Gram-positive bacterium: 20 years of annotation refinement. Borriss R, et al. Microb Biotechnol, 2018 Jan. PMID 29280348, Free PMC Article
  3. An updated metabolic view of the Bacillus subtilis 168 genome. Belda E, et al. Microbiology (Reading), 2013 Apr. PMID 23429746
  4. From a consortium sequence to a unified sequence: the Bacillus subtilis 168 reference genome a decade later. Barbe V, et al. Microbiology (Reading), 2009 Jun. PMID 19383706, Free PMC Article
  5. The complete genome sequence of the gram-positive bacterium Bacillus subtilis. Kunst F, et al. Nature, 1997 Nov 20. PMID 9384377

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases have a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds
    Title: Crystal structures of two bacterial 3-hydroxy-3-methylglutaryl-CoA lyases suggest a common catalytic mechanism among a family of TIM barrel metalloenzymes cleaving carbon-carbon bonds.
Submit: New GeneRIF Correction

General gene information

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Homology

General protein information

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Preferred Names
hydroxymethylglutaryl-CoA lyase (leucine degradation)
NP_389705.1
  • Evidence 2b: Function from indirect experimental evidences (e.g. phenotypes); PubMedId: 16330546, 19935659, 22720735; Product type e: enzyme

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_000964.3 Reference assembly

    Range
    1952031..1952930 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NP_389705.1 hydroxymethylglutaryl-CoA lyase (leucine degradation) [Bacillus subtilis subsp. subtilis str. 168]

    See identical proteins and their annotated locations for NP_389705.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    A0A0D1LAG6
    Conserved Domains (1) summary
    PRK05692
    Location:3 → 289
    PRK05692; hydroxymethylglutaryl-CoA lyase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O34873.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases