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SLC22A14 solute carrier family 22 member 14 [ Homo sapiens (human) ]

Gene ID: 9389, updated on 11-Sep-2019

Summary

Official Symbol
SLC22A14provided by HGNC
Official Full Name
solute carrier family 22 member 14provided by HGNC
Primary source
HGNC:HGNC:8495
See related
Ensembl:ENSG00000144671 MIM:604048
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OCTL2; OCTL4; ORCTL4
Summary
This gene encodes a member of the organic-cation transporter family. It is located in a gene cluster with another member of the family, organic cation transporter like 3. The encoded protein is a transmembrane protein which is thought to transport small molecules and since this protein is conserved among several species, it is suggested to have a fundamental role in mammalian systems. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Expression
Restricted expression toward testis (RPKM 3.4) See more
Orthologs

Genomic context

See SLC22A14 in Genome Data Viewer
Location:
3p22.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (38281662..38318575)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38323785..38360064)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cell division cycle 42 pseudogene Neighboring gene Sharpr-MPRA regulatory region 5010 Neighboring gene solute carrier family 22 member 13 Neighboring gene RNA, U6 small nuclear 235, pseudogene Neighboring gene DLEC1 pseudogene 1 Neighboring gene xylulokinase Neighboring gene ACVR2B antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Homology

Clone Names

  • MGC163415

Gene Ontology Provided by GOA

Function Evidence Code Pubs
organic cation transmembrane transporter activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
organic cation transport NAS
Non-traceable Author Statement
more info
PubMed 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
solute carrier family 22 member 14
Names
ORCTL-4
organic cation transporter-like 4
organic cationic transporter-like 4
solute carrier family 22 (organic cation transporter), member 14

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320033.1NP_001306962.1  solute carrier family 22 member 14

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AI446196, AK315317, AP006193, DB024161, HY221852
    Consensus CDS
    CCDS2677.1
    UniProtKB/Swiss-Prot
    Q9Y267
    Related
    ENSP00000396283.1, ENST00000448498.5
    Conserved Domains (2) summary
    cd06174
    Location:189560
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:60569
    2A0119; cation transport protein
  2. NM_004803.4NP_004794.2  solute carrier family 22 member 14

    See identical proteins and their annotated locations for NP_004794.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB011082, AI446196, AP006193, BC130543, HY221852
    Consensus CDS
    CCDS2677.1
    UniProtKB/Swiss-Prot
    Q9Y267
    Related
    ENSP00000273173.4, ENST00000273173.4
    Conserved Domains (2) summary
    cd06174
    Location:189560
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:60569
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    38281662..38318575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534245.2XP_011532547.1  solute carrier family 22 member 14 isoform X4

    See identical proteins and their annotated locations for XP_011532547.1

    UniProtKB/Swiss-Prot
    Q9Y267
    Conserved Domains (2) summary
    cd06174
    Location:189560
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:60569
    2A0119; cation transport protein
  2. XM_005265585.4XP_005265642.1  solute carrier family 22 member 14 isoform X4

    See identical proteins and their annotated locations for XP_005265642.1

    UniProtKB/Swiss-Prot
    Q9Y267
    Conserved Domains (2) summary
    cd06174
    Location:189560
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:60569
    2A0119; cation transport protein
  3. XM_006713416.3XP_006713479.2  solute carrier family 22 member 14 isoform X1

    Conserved Domains (2) summary
    cd06174
    Location:270641
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:141650
    2A0119; cation transport protein
  4. XM_006713417.3XP_006713480.2  solute carrier family 22 member 14 isoform X2

    Conserved Domains (2) summary
    cd06174
    Location:270630
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:141639
    2A0119; cation transport protein
  5. XM_006713418.4XP_006713481.2  solute carrier family 22 member 14 isoform X3

    Conserved Domains (2) summary
    cd06174
    Location:270399
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:141596
    2A0119; cation transport protein
  6. XM_011534247.2XP_011532549.1  solute carrier family 22 member 14 isoform X5

    Conserved Domains (2) summary
    cd06174
    Location:270399
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:141468
    2A0119; cation transport protein
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