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Vangl2 VANGL planar cell polarity 2 [ Mus musculus (house mouse) ]

Gene ID: 93840, updated on 7-Sep-2021

Summary

Official Symbol
Vangl2provided by MGI
Official Full Name
VANGL planar cell polarity 2provided by MGI
Primary source
MGI:MGI:2135272
See related
Ensembl:ENSMUSG00000026556
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
L; Lp; lo; ska; Lpp1; Ltap; stbm; stra; Lootl; ska17; Vang1l2; ska<m17J; loop-tail; strabismus; ska<m17Jus>; C530001F03Rik
Expression
Broad expression in CNS E11.5 (RPKM 15.1), whole brain E14.5 (RPKM 14.6) and 19 other tissues See more
Orthologs
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Genomic context

See Vangl2 in Genome Data Viewer
Location:
1 H3; 1 79.54 cM
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171828527..171856532, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (172000960..172027318, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (173934502..173957399, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene 52845 Neighboring gene predicted gene, 37065 Neighboring gene SLAM family member 6 Neighboring gene VISTA enhancer mm1677 Neighboring gene nescient helix loop helix 1 Neighboring gene nicastrin Neighboring gene coatomer protein complex subunit alpha

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Spontaneous (2) 
  • Targeted (11)  1 citation
  • Chemically induced (ENU) (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Wnt signaling pathway, planar cell polarity pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apical protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in branching involved in blood vessel morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in cardiac vascular smooth muscle cell differentiation TAS
Traceable Author Statement
more info
PubMed 
involved_in cell migration involved in kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cochlea development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cochlea morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cochlea morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in neural plate elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in neural plate elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in organogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within digestive tract morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dopaminergic neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epicardial cell to mesenchymal cell transition TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within establishment of body hair planar orientation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of epithelial cell polarity TAS
Traceable Author Statement
more info
PubMed 
involved_in establishment of planar polarity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within establishment of planar polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment of planar polarity involved in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within glomerulus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hair follicle development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in heart looping IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within heparan sulfate proteoglycan biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear receptor cell development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inner ear receptor cell stereocilium organization IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within inner ear receptor cell stereocilium organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lateral sprouting involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within membranous septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscular septum morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within non-motile cilium assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within orthogonal dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in outflow tract septum morphogenesis TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in axis elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in planar cell polarity pathway involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in heart morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within planar dichotomous subdivision of terminal units involved in lung branching morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of JUN kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of actin cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of establishment of planar polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in serotonergic neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somatic stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within wound healing IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in COPII-coated ER to Golgi transport vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell periphery IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell pole IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in lateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in stress fiber IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vang-like protein 2
Names
loop tail associated protein
loop-tail protein 1
van Gogh-like protein 2
vang-like 2 (van gogh, Drosophila)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_033509.4NP_277044.1  vang-like protein 2

    See identical proteins and their annotated locations for NP_277044.1

    Status: VALIDATED

    Source sequence(s)
    AC158930, AF365875, AK049613, AK082938, AW046551, BC075636, BY320814
    Consensus CDS
    CCDS15505.1
    UniProtKB/Swiss-Prot
    Q91ZD4
    Related
    ENSMUSP00000027837.7, ENSMUST00000027837.13
    Conserved Domains (1) summary
    pfam06638
    Location:34521
    Strabismus; Strabismus protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171828527..171856532 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036154495.1XP_036010388.1  vang-like protein 2 isoform X1

    Conserved Domains (1) summary
    pfam06638
    Location:34521
    Strabismus; Strabismus protein
  2. XM_006497051.5XP_006497114.1  vang-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006497114.1

    UniProtKB/Swiss-Prot
    Q91ZD4
    Conserved Domains (1) summary
    pfam06638
    Location:34521
    Strabismus; Strabismus protein
  3. XM_006497053.5XP_006497116.1  vang-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006497116.1

    UniProtKB/Swiss-Prot
    Q91ZD4
    Conserved Domains (1) summary
    pfam06638
    Location:34521
    Strabismus; Strabismus protein
  4. XM_006497052.5XP_006497115.1  vang-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006497115.1

    UniProtKB/Swiss-Prot
    Q91ZD4
    Conserved Domains (1) summary
    pfam06638
    Location:34521
    Strabismus; Strabismus protein
  5. XM_036154494.1XP_036010387.1  vang-like protein 2 isoform X1

    Conserved Domains (1) summary
    pfam06638
    Location:34521
    Strabismus; Strabismus protein
  6. XM_006497054.5XP_006497117.1  vang-like protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006497117.1

    UniProtKB/Swiss-Prot
    Q91ZD4
    Conserved Domains (1) summary
    pfam06638
    Location:34521
    Strabismus; Strabismus protein
  7. XM_017313008.3XP_017168497.1  vang-like protein 2 isoform X1

    UniProtKB/Swiss-Prot
    Q91ZD4
    Conserved Domains (1) summary
    pfam06638
    Location:34521
    Strabismus; Strabismus protein

RNA

  1. XR_003947338.2 RNA Sequence

  2. XR_004935287.1 RNA Sequence

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