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Rnf111 ring finger 111 [ Mus musculus (house mouse) ]

Gene ID: 93836, updated on 9-Mar-2023

Summary

Official Symbol
Rnf111provided by MGI
Official Full Name
ring finger 111provided by MGI
Primary source
MGI:MGI:1934919
See related
Ensembl:ENSMUSG00000032217 AllianceGenome:MGI:1934919
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ARK; Arkadia
Summary
Enables ubiquitin protein ligase activity. Involved in positive regulation of transcription, DNA-templated. Acts upstream of or within several processes, including cellular protein metabolic process; positive regulation of protein ubiquitination; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. Part of protein-containing complex. Is expressed in several structures, including heart; nervous system; testis; and urinary system. Orthologous to human RNF111 (ring finger protein 111). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 22.4), spleen adult (RPKM 21.0) and 28 other tissues See more
Orthologs
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Genomic context

See Rnf111 in Genome Data Viewer
Location:
9 D; 9 39.53 cM
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (70332706..70411122, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (70425424..70503840, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene microRNA 5626 Neighboring gene cyclin B2 Neighboring gene predicted gene, 24615 Neighboring gene predicted gene, 23730 Neighboring gene predicted gene, 22229

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SMAD binding ISO
Inferred from Sequence Orthology
more info
 
enables SUMO polymer binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables SUMO polymer binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin protein ligase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within DNA repair IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within pattern specification process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within protein polyubiquitination IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein polyubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in ubiquitin-dependent SMAD protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within ubiquitin-dependent SMAD protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent SMAD protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase Arkadia
Names
RING finger protein 111
RING-type E3 ubiquitin transferase Arkadia
NP_001344423.1
NP_001361682.1
NP_291082.1
XP_006511639.1
XP_006511640.1
XP_006511641.1
XP_006511643.1
XP_006511644.1
XP_006511645.1
XP_006511646.1
XP_006511647.1
XP_011241143.1
XP_017169198.1
XP_030100606.1
XP_030100607.1
XP_030100608.1
XP_030100610.1
XP_030100611.1
XP_036011314.1
XP_036011315.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357494.1NP_001344423.1  E3 ubiquitin-protein ligase Arkadia isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC157086, AC158995
    Consensus CDS
    CCDS90614.1
    Related
    ENSMUSP00000149445.2, ENSMUST00000215848.2
    Conserved Domains (3) summary
    cd16474
    Location:928972
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam09770
    Location:665798
    PAT1; Topoisomerase II-associated protein PAT1
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  2. NM_001374753.1NP_001361682.1  E3 ubiquitin-protein ligase Arkadia isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC157086, AC158995
    Consensus CDS
    CCDS90613.1
    UniProtKB/TrEMBL
    A0A1L1SRK3
    Conserved Domains (3) summary
    cd16474
    Location:927971
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam08192
    Location:278425
    Peptidase_S64; Peptidase family S64
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  3. NM_033604.3NP_291082.1  E3 ubiquitin-protein ligase Arkadia isoform 1

    See identical proteins and their annotated locations for NP_291082.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC157086, AC158995
    Consensus CDS
    CCDS23321.1
    UniProtKB/Swiss-Prot
    Q8CBC0, Q99ML9
    Related
    ENSMUSP00000034739.6, ENSMUST00000034739.12
    Conserved Domains (3) summary
    cd16474
    Location:936980
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam09770
    Location:665798
    PAT1; Topoisomerase II-associated protein PAT1
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    70332706..70411122 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244751.2XP_030100611.1  E3 ubiquitin-protein ligase Arkadia isoform X13

    Conserved Domains (3) summary
    cd16474
    Location:928972
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam09770
    Location:665798
    PAT1; Topoisomerase II-associated protein PAT1
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  2. XM_036155421.1XP_036011314.1  E3 ubiquitin-protein ligase Arkadia isoform X10

    Conserved Domains (3) summary
    cd16474
    Location:937981
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam08192
    Location:278425
    Peptidase_S64; Peptidase family S64
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  3. XM_006511580.4XP_006511643.1  E3 ubiquitin-protein ligase Arkadia isoform X6

    Conserved Domains (3) summary
    cd16474
    Location:10271071
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam09770
    Location:764897
    PAT1; Topoisomerase II-associated protein PAT1
    pfam15303
    Location:117388
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  4. XM_006511577.4XP_006511640.1  E3 ubiquitin-protein ligase Arkadia isoform X3

    Conserved Domains (2) summary
    cd16474
    Location:10361080
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam15303
    Location:117388
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  5. XM_006511576.3XP_006511639.1  E3 ubiquitin-protein ligase Arkadia isoform X1

    Conserved Domains (2) summary
    cd16474
    Location:10441088
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam15303
    Location:117388
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  6. XM_036155422.1XP_036011315.1  E3 ubiquitin-protein ligase Arkadia isoform X14

    UniProtKB/TrEMBL
    A0A1L1SRK3
    Related
    ENSMUSP00000149501.2, ENSMUST00000213647.2
    Conserved Domains (3) summary
    cd16474
    Location:927971
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam08192
    Location:278425
    Peptidase_S64; Peptidase family S64
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  7. XM_006511581.5XP_006511644.1  E3 ubiquitin-protein ligase Arkadia isoform X7

    Conserved Domains (4) summary
    pfam05539
    Location:488661
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
    cd16474
    Location:10261070
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam09770
    Location:763896
    PAT1; Topoisomerase II-associated protein PAT1
    pfam15303
    Location:117388
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  8. XM_030244750.1XP_030100610.1  E3 ubiquitin-protein ligase Arkadia isoform X12

    Conserved Domains (4) summary
    pfam05539
    Location:389562
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
    cd16474
    Location:935979
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam09770
    Location:664797
    PAT1; Topoisomerase II-associated protein PAT1
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  9. XM_030244747.2XP_030100607.1  E3 ubiquitin-protein ligase Arkadia isoform X9

    Conserved Domains (3) summary
    pfam05539
    Location:389562
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
    cd16474
    Location:944988
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  10. XM_030244748.2XP_030100608.1  E3 ubiquitin-protein ligase Arkadia isoform X11

    UniProtKB/Swiss-Prot
    Q8CBC0
    Conserved Domains (3) summary
    cd16474
    Location:936980
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam09770
    Location:665798
    PAT1; Topoisomerase II-associated protein PAT1
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  11. XM_006511582.4XP_006511645.1  E3 ubiquitin-protein ligase Arkadia isoform X8

    See identical proteins and their annotated locations for XP_006511645.1

    Conserved Domains (2) summary
    cd16474
    Location:945989
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  12. XM_030244746.2XP_030100606.1  E3 ubiquitin-protein ligase Arkadia isoform X9

    Conserved Domains (3) summary
    pfam05539
    Location:389562
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
    cd16474
    Location:944988
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  13. XM_006511583.5XP_006511646.1  E3 ubiquitin-protein ligase Arkadia isoform X8

    See identical proteins and their annotated locations for XP_006511646.1

    Conserved Domains (2) summary
    cd16474
    Location:945989
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  14. XM_006511584.4XP_006511647.1  E3 ubiquitin-protein ligase Arkadia isoform X8

    See identical proteins and their annotated locations for XP_006511647.1

    Conserved Domains (2) summary
    cd16474
    Location:945989
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam15303
    Location:18289
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  15. XM_011242841.4XP_011241143.1  E3 ubiquitin-protein ligase Arkadia isoform X2

    Conserved Domains (3) summary
    pfam05539
    Location:488661
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
    cd16474
    Location:10431087
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam15303
    Location:117388
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  16. XM_006511578.5XP_006511641.1  E3 ubiquitin-protein ligase Arkadia isoform X4

    Conserved Domains (3) summary
    cd16474
    Location:10351079
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam09770
    Location:764897
    PAT1; Topoisomerase II-associated protein PAT1
    pfam15303
    Location:117388
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus
  17. XM_017313709.2XP_017169198.1  E3 ubiquitin-protein ligase Arkadia isoform X5

    Conserved Domains (4) summary
    pfam05539
    Location:488661
    Pneumo_att_G; Pneumovirinae attachment membrane glycoprotein G
    cd16474
    Location:10341078
    RING-H2_RNF111_like; RING finger, H2 subclass, found in RING finger proteins RNF111, RNF165, and similar proteins
    pfam09770
    Location:763896
    PAT1; Topoisomerase II-associated protein PAT1
    pfam15303
    Location:117388
    RNF111_N; E3 ubiquitin-protein ligase Arkadia N-terminus