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GRHPR glyoxylate and hydroxypyruvate reductase [ Homo sapiens (human) ]

Gene ID: 9380, updated on 7-Dec-2018

Summary

Official Symbol
GRHPRprovided by HGNC
Official Full Name
glyoxylate and hydroxypyruvate reductaseprovided by HGNC
Primary source
HGNC:HGNC:4570
See related
Ensembl:ENSG00000137106 MIM:604296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PH2; GLXR; GLYD
Summary
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver (RPKM 132.9), kidney (RPKM 67.4) and 24 other tissues See more
Orthologs

Genomic context

See GRHPR in Genome Data Viewer
Location:
9p13.2
Exon count:
11
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 9 NC_000009.12 (37422435..37438952)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37422693..37436990)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene zinc finger CCHC-type containing 7 Neighboring gene RNA, U6 small nuclear 677, pseudogene Neighboring gene uncharacterized LOC105376035 Neighboring gene long intergenic non-protein coding RNA 1627 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 3 Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 3 Neighboring gene ribosomal protein L21 pseudogene 83 Neighboring gene RNA polymerase I subunit E

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
NAD binding TAS
Traceable Author Statement
more info
PubMed 
NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
carboxylic acid binding IEA
Inferred from Electronic Annotation
more info
 
glycerate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
glyoxylate reductase (NADP) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glyoxylate reductase (NADP) activity IDA
Inferred from Direct Assay
more info
PubMed 
glyoxylate reductase (NADP) activity TAS
Traceable Author Statement
more info
 
hydroxypyruvate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
hydroxypyruvate reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular nitrogen compound metabolic process TAS
Traceable Author Statement
more info
 
dicarboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
excretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
glyoxylate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
oxidation-reduction process IDA
Inferred from Direct Assay
more info
PubMed 
protein complex oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular exosome HDA PubMed 
peroxisomal matrix TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glyoxylate reductase/hydroxypyruvate reductase
Names
epididymis secretory sperm binding protein
glycerate-2-dehydrogenase
glyoxylate reductase and hydroxypyruvate reductase
NP_036335.1
XP_005251688.1
XP_016870809.1
XP_016870810.1
XP_016870812.1
XP_024303484.1
XP_024303485.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008135.1 RefSeqGene

    Range
    5001..19280
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012203.2NP_036335.1  glyoxylate reductase/hydroxypyruvate reductase

    See identical proteins and their annotated locations for NP_036335.1

    Status: REVIEWED

    Source sequence(s)
    AF134895, AL158155
    Consensus CDS
    CCDS6609.1
    UniProtKB/Swiss-Prot
    Q9UBQ7
    Related
    ENSP00000313432.6, ENST00000318158.10
    Conserved Domains (1) summary
    cd05301
    Location:7319
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p12 Primary Assembly

    Range
    37422435..37438952
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447716.1XP_024303484.1  glyoxylate reductase/hydroxypyruvate reductase isoform X1

    Conserved Domains (1) summary
    cd05301
    Location:117379
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)
  2. XM_024447717.1XP_024303485.1  glyoxylate reductase/hydroxypyruvate reductase isoform X2

    Conserved Domains (1) summary
    cd05301
    Location:117379
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)
  3. XM_017015323.2XP_016870812.1  glyoxylate reductase/hydroxypyruvate reductase isoform X6

  4. XM_017015320.2XP_016870809.1  glyoxylate reductase/hydroxypyruvate reductase isoform X3

  5. XM_017015321.2XP_016870810.1  glyoxylate reductase/hydroxypyruvate reductase isoform X4

  6. XM_005251631.1XP_005251688.1  glyoxylate reductase/hydroxypyruvate reductase isoform X5

    See identical proteins and their annotated locations for XP_005251688.1

    Conserved Domains (2) summary
    COG1052
    Location:11220
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cl21454
    Location:11212
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. XR_002956828.1 RNA Sequence

  2. XR_002956829.1 RNA Sequence

  3. XR_002956832.1 RNA Sequence

  4. XR_002956830.1 RNA Sequence

  5. XR_002956831.1 RNA Sequence

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