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GRHPR glyoxylate and hydroxypyruvate reductase [ Homo sapiens (human) ]

Gene ID: 9380, updated on 12-Aug-2022

Summary

Official Symbol
GRHPRprovided by HGNC
Official Full Name
glyoxylate and hydroxypyruvate reductaseprovided by HGNC
Primary source
HGNC:HGNC:4570
See related
Ensembl:ENSG00000137106 MIM:604296; AllianceGenome:HGNC:4570
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PH2; GLXR; GLYD
Summary
This gene encodes an enzyme with hydroxypyruvate reductase, glyoxylate reductase, and D-glycerate dehydrogenase enzymatic activities. The enzyme has widespread tissue expression and has a role in metabolism. Type II hyperoxaluria is caused by mutations in this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in liver (RPKM 132.9), kidney (RPKM 67.4) and 24 other tissues See more
Orthologs
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Genomic context

See GRHPR in Genome Data Viewer
Location:
9p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (37422435..37439494)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (37446388..37460683)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37422693..37436987)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902154 Neighboring gene uncharacterized LOC105376035 Neighboring gene Sharpr-MPRA regulatory region 8540 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 3 Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene potassium channel tetramerization domain containing 9 pseudogene 3 Neighboring gene RNA polymerase I subunit E Neighboring gene ribosomal protein L21 pseudogene 83

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
 
enables NADPH binding IDA
Inferred from Direct Assay
more info
PubMed 
enables carboxylic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables glycerate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glycerate dehydrogenase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glyoxylate reductase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glyoxylate reductase (NADP+) activity IDA
Inferred from Direct Assay
more info
PubMed 
enables glyoxylate reductase (NADP+) activity TAS
Traceable Author Statement
more info
 
enables hydroxypyruvate reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables hydroxypyruvate reductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process TAS
Traceable Author Statement
more info
 
involved_in dicarboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in glyoxylate metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of catalytic complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
located_in peroxisomal matrix TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
glyoxylate reductase/hydroxypyruvate reductase
Names
epididymis secretory sperm binding protein
glycerate-2-dehydrogenase
glyoxylate reductase and hydroxypyruvate reductase
NP_036335.1
XP_005251688.1
XP_016870809.1
XP_016870810.1
XP_016870812.1
XP_024303484.1
XP_047280040.1
XP_047280041.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_008135.1 RefSeqGene

    Range
    4987..19281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_012203.2NP_036335.1  glyoxylate reductase/hydroxypyruvate reductase

    See identical proteins and their annotated locations for NP_036335.1

    Status: REVIEWED

    Source sequence(s)
    AF134895, AL158155
    Consensus CDS
    CCDS6609.1
    UniProtKB/Swiss-Prot
    Q9UBQ7, Q9UKX1
    UniProtKB/TrEMBL
    A0A384N605
    Related
    ENSP00000313432.6, ENST00000318158.11
    Conserved Domains (1) summary
    cd05301
    Location:7319
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    37422435..37439494
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447716.2XP_024303484.1  glyoxylate reductase/hydroxypyruvate reductase isoform X1

    Conserved Domains (1) summary
    cd05301
    Location:117379
    GDH; D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH)
  2. XM_017015321.3XP_016870810.1  glyoxylate reductase/hydroxypyruvate reductase isoform X3

  3. XM_017015320.3XP_016870809.1  glyoxylate reductase/hydroxypyruvate reductase isoform X2

  4. XM_047424084.1XP_047280040.1  glyoxylate reductase/hydroxypyruvate reductase isoform X4

  5. XM_005251631.2XP_005251688.1  glyoxylate reductase/hydroxypyruvate reductase isoform X5

    See identical proteins and their annotated locations for XP_005251688.1

    Conserved Domains (2) summary
    COG1052
    Location:11220
    LdhA; Lactate dehydrogenase or related 2-hydroxyacid dehydrogenase [Energy production and conversion, Coenzyme transport and metabolism, General function prediction only]
    cl21454
    Location:11212
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  6. XM_017015323.3XP_016870812.1  glyoxylate reductase/hydroxypyruvate reductase isoform X6

  7. XM_047424085.1XP_047280041.1  glyoxylate reductase/hydroxypyruvate reductase isoform X7

RNA

  1. XR_002956828.2 RNA Sequence

  2. XR_007061375.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    37446388..37460683
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)