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SLC22A8 solute carrier family 22 member 8 [ Homo sapiens (human) ]

Gene ID: 9376, updated on 9-Jun-2020

Summary

Official Symbol
SLC22A8provided by HGNC
Official Full Name
solute carrier family 22 member 8provided by HGNC
Primary source
HGNC:HGNC:10972
See related
Ensembl:ENSG00000149452 MIM:607581
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OAT3
Summary
This gene encodes a protein involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, May 2010]
Expression
Restricted expression toward kidney (RPKM 184.6) See more
Orthologs

Genomic context

See SLC22A8 in Genome Data Viewer
Location:
11q12.3
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (62992824..63015845, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62760296..62783317, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369333 Neighboring gene RNA, 7SL, cytoplasmic 259, pseudogene Neighboring gene solute carrier family 22 member 6 Neighboring gene PTTG1 regulator of sister chromatid separation, securin pseudogene Neighboring gene tubulin alpha pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC24086

Gene Ontology Provided by GOA

Function Evidence Code Pubs
inorganic anion exchanger activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
inorganic anion transport IEA
Inferred from Electronic Annotation
more info
 
response to toxic substance IEA
Inferred from Electronic Annotation
more info
 
transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
basolateral plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
solute carrier family 22 member 8
Names
hOAT3
organic anion transporter 3
solute carrier family 22 (organic anion transporter), member 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001184732.1NP_001171661.1  solute carrier family 22 member 8 isoform 1

    See identical proteins and their annotated locations for NP_001171661.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses a different splice site in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AB042505, AK313187, BC022387, DA628705, DA633836
    Consensus CDS
    CCDS8042.1
    UniProtKB/Swiss-Prot
    Q8TCC7
    UniProtKB/TrEMBL
    B2R807
    Related
    ENSP00000398548.2, ENST00000430500.6
    Conserved Domains (2) summary
    cd06174
    Location:96493
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11503
    2A0119; cation transport protein
  2. NM_001184733.1NP_001171662.1  solute carrier family 22 member 8 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses a different splice site and lacks a portion of the 5' coding region, with the result of translation initiation at an alternate start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AB042505, AK298341, BP276255, DA628705
    Consensus CDS
    CCDS53644.1
    UniProtKB/Swiss-Prot
    Q8TCC7
    Related
    ENSP00000441658.1, ENST00000545207.5
    Conserved Domains (2) summary
    cd06174
    Location:33402
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    pfam00083
    Location:9411
    Sugar_tr; Sugar (and other) transporter
  3. NM_001184736.1NP_001171665.1  solute carrier family 22 member 8 isoform 3

    See identical proteins and their annotated locations for NP_001171665.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region and uses a downstream start codon, compared to variant 1. Isoform 3 has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AB042505, AK307850, BC022387, DA628705
    Consensus CDS
    CCDS53643.1
    UniProtKB/Swiss-Prot
    Q8TCC7
    Related
    ENSP00000443368.1, ENST00000535878.5
    Conserved Domains (1) summary
    cd06174
    Location:1370
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
  4. NM_004254.4NP_004245.2  solute carrier family 22 member 8 isoform 1

    See identical proteins and their annotated locations for NP_004245.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AB042505, BC022387, DA628705
    Consensus CDS
    CCDS8042.1
    UniProtKB/Swiss-Prot
    Q8TCC7
    Related
    ENSP00000337335.2, ENST00000336232.7
    Conserved Domains (2) summary
    cd06174
    Location:96493
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    TIGR00898
    Location:11503
    2A0119; cation transport protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    62992824..63015845 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545364.1XP_011543666.1  solute carrier family 22 member 8 isoform X1

    See identical proteins and their annotated locations for XP_011543666.1

    UniProtKB/Swiss-Prot
    Q8TCC7
    Conserved Domains (1) summary
    cd06174
    Location:1370
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
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