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Pard3 par-3 family cell polarity regulator [ Mus musculus (house mouse) ]

Gene ID: 93742, updated on 12-Sep-2017
Official Symbol
Pard3provided by MGI
Official Full Name
par-3 family cell polarity regulatorprovided by MGI
Primary source
MGI:MGI:2135608
See related
Ensembl:ENSMUSG00000025812 Vega:OTTMUSG00000034639
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Asip; Par3; Phip; Par-3; Pard-3; Pard3a; AA960621; AI256638; D8Ertd580e
Orthologs
Location:
8 E2; 8 74.66 cM
Exon count:
28
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 8 NC_000074.6 (127063872..127612286)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (129587956..130136186)

Chromosome 8 - NC_000074.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 38574 Neighboring gene GABA(A) receptor-associated protein like 2 pseudogene 8_1688.1 Neighboring gene uncharacterized LOC102634904 Neighboring gene predicted pseudogene 6921 Neighboring gene predicted gene, 32478 Neighboring gene predicted gene, 32532

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
lipid binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-3-phosphate binding ISO
Inferred from Sequence Orthology
more info
 
phosphatidylinositol-4,5-bisphosphate binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
apical constriction IGI
Inferred from Genetic Interaction
more info
PubMed 
bicellular tight junction assembly ISO
Inferred from Sequence Orthology
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion IC
Inferred by Curator
more info
PubMed 
centrosome localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of epithelial cell polarity ISO
Inferred from Sequence Orthology
more info
 
establishment or maintenance of cell polarity TAS
Traceable Author Statement
more info
PubMed 
microtubule cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
myelination in peripheral nervous system IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of peptidyl-threonine phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of receptor internalization IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
 
regulation of actin filament-based process IGI
Inferred from Genetic Interaction
more info
PubMed 
regulation of cellular localization ISO
Inferred from Sequence Orthology
more info
 
wound healing, spreading of cells IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Schmidt-Lanterman incisure IDA
Inferred from Direct Assay
more info
PubMed 
adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
apical junction complex IDA
Inferred from Direct Assay
more info
PubMed 
apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
axonal growth cone ISO
Inferred from Sequence Orthology
more info
 
bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell junction ISO
Inferred from Sequence Orthology
more info
 
cell-cell adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell junction ISO
Inferred from Sequence Orthology
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
internode region of axon IDA
Inferred from Direct Assay
more info
PubMed 
lateral loop IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
protein complex IDA
Inferred from Direct Assay
more info
PubMed 
protein complex ISO
Inferred from Sequence Orthology
more info
 
spindle IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
partitioning defective 3 homolog
Names
atypical PKC isotype-specific-interacting protein
ephrin-interacting protein
par-3 (partitioning defective 3) homolog

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001013580.3NP_001013598.1  partitioning defective 3 homolog isoform 2

    See identical proteins and their annotated locations for NP_001013598.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2, also called PAR-3o2) differs in the 5' and 3' UTR and has multiple coding region differences compared to variant 5. These differences cause translation initiation at a downstream AUG and an isoform (2) with a shorter N-terminus and shorter and distinct C-terminus compared to isoform 5.
    Source sequence(s)
    AC105981, AK052416, CF172228
    Consensus CDS
    CCDS40523.1
    UniProtKB/Swiss-Prot
    Q99NH2
    Related
    ENSMUSP00000125612.1, OTTMUSP00000047889, ENSMUST00000160717.7, OTTMUST00000087925
    Conserved Domains (1) summary
    cd00992
    Location:330409
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  2. NM_001013581.2NP_001013599.1  partitioning defective 3 homolog isoform 1

    See identical proteins and their annotated locations for NP_001013599.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1, also called PAR-3o1) differs in the 5' and 3' UTR and has multiple coding region differences compared to variant 5. These differences cause translation initiation at a downstream AUG and an isoform (1) with a shorter N-terminus and shorter and distinct C-terminus compared to isoform 5.
    Source sequence(s)
    AY856082
    Consensus CDS
    CCDS22789.1
    UniProtKB/Swiss-Prot
    Q99NH2
    UniProtKB/TrEMBL
    A0A0R4J1Y4
    Related
    ENSMUSP00000124162.1, OTTMUSP00000047891, ENSMUST00000162456.7, OTTMUST00000087928
    Conserved Domains (1) summary
    cd00992
    Location:330409
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
  3. NM_001122850.1NP_001116322.1  partitioning defective 3 homolog isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 3' UTR and coding region compared to variant 5. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 5.
    Source sequence(s)
    AC105981, AK052416, BC090616
    Consensus CDS
    CCDS52712.1
    UniProtKB/TrEMBL
    A5D6P2, E9PYJ2
    Related
    ENSMUSP00000124319.1, OTTMUSP00000047888, ENSMUST00000162907.7, OTTMUST00000087924
    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  4. NM_001309391.1NP_001296320.1  partitioning defective 3 homolog isoform 5

    See identical proteins and their annotated locations for NP_001296320.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (5).
    Source sequence(s)
    BC090616
    Consensus CDS
    CCDS80945.1
    UniProtKB/TrEMBL
    A5D6P2
    Related
    ENSMUSP00000125453.1, OTTMUSP00000047887, ENSMUST00000160272.7, OTTMUST00000087923
    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  5. NM_001309392.1NP_001296321.1  partitioning defective 3 homolog isoform 6

    See identical proteins and their annotated locations for NP_001296321.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks an in-frame exon in the central coding region, compared to variant 5. The encoded isoform (6) is shorter than isoform 5.
    Source sequence(s)
    BC090616
    Consensus CDS
    CCDS80946.1
    UniProtKB/TrEMBL
    A5D6P2, B7ZNY3
    Related
    ENSMUSP00000026921.6, OTTMUSP00000047890, ENSMUST00000026921.12, OTTMUST00000087927
    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  6. NM_033620.2NP_296369.2  partitioning defective 3 homolog isoform 3

    See identical proteins and their annotated locations for NP_296369.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 5. The encoded isoform (3) is shorter than isoform 5.
    Source sequence(s)
    BC090616
    Consensus CDS
    CCDS22788.1
    UniProtKB/TrEMBL
    A5D6P2, G3XA13
    Related
    ENSMUSP00000124282.1, OTTMUSP00000047886, ENSMUST00000162309.7, OTTMUST00000087922
    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000074.6 Reference GRCm38.p4 C57BL/6J

    Range
    127063872..127612286
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531526.2XP_006531589.1  partitioning defective 3 homolog isoform X5

    Conserved Domains (2) summary
    cd00992
    Location:437516
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  2. XM_006531520.2XP_006531583.1  partitioning defective 3 homolog isoform X1

    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  3. XM_006531523.2XP_006531586.1  partitioning defective 3 homolog isoform X3

    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  4. XM_006531521.2XP_006531584.1  partitioning defective 3 homolog isoform X2

    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  5. XM_006531524.2XP_006531587.1  partitioning defective 3 homolog isoform X4

    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  6. XM_006531527.2XP_006531590.1  partitioning defective 3 homolog isoform X6

    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  7. XM_006531528.2XP_006531591.1  partitioning defective 3 homolog isoform X7

    See identical proteins and their annotated locations for XP_006531591.1

    UniProtKB/TrEMBL
    B2RUK1
    Related
    ENSMUSP00000124718.1, OTTMUSP00000047892, ENSMUST00000162665.7, OTTMUST00000087929
    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  8. XM_006531529.2XP_006531592.1  partitioning defective 3 homolog isoform X8

    Related
    ENSMUSP00000125450.1, OTTMUSP00000047902, ENSMUST00000162602.7, OTTMUST00000087940
    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  9. XM_006531530.2XP_006531593.1  partitioning defective 3 homolog isoform X9

    Related
    ENSMUSP00000124934.1, OTTMUSP00000047899, ENSMUST00000159537.7, OTTMUST00000087937
    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  10. XM_006531531.2XP_006531594.1  partitioning defective 3 homolog isoform X10

    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  11. XM_006531532.2XP_006531595.1  partitioning defective 3 homolog isoform X11

    Related
    ENSMUSP00000125064.1, OTTMUSP00000047906, ENSMUST00000161355.7, OTTMUST00000087944
    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
  12. XM_006531533.2XP_006531596.1  partitioning defective 3 homolog isoform X12

    Conserved Domains (2) summary
    cd00992
    Location:465544
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam12053
    Location:1146
    DUF3534; Domain of unknown function (DUF3534)
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