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Acox2 acyl-Coenzyme A oxidase 2, branched chain [ Mus musculus (house mouse) ]

Gene ID: 93732, updated on 31-Jan-2019

Summary

Official Symbol
Acox2provided by MGI
Official Full Name
acyl-Coenzyme A oxidase 2, branched chainprovided by MGI
Primary source
MGI:MGI:1934852
See related
Ensembl:ENSMUSG00000021751
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
THCCox
Expression
Biased expression in liver adult (RPKM 75.3), kidney adult (RPKM 54.4) and 6 other tissues See more
Orthologs

Genomic context

See Acox2 in Genome Data Viewer
Location:
14; 14 A1
Exon count:
16
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (8225511..8259019, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (9058025..9091533, complement)

Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene pyruvate dehydrogenase (lipoamide) beta Neighboring gene potassium channel tetramerisation domain containing 6 Neighboring gene family with sequence similarity 107, member A Neighboring gene RIKEN cDNA 2610318M16 gene Neighboring gene oncoprotein induced transcript 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from BioSystems

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoyl-CoA 24-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
 
FAD binding IEA
Inferred from Electronic Annotation
more info
 
acyl-CoA oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid binding ISO
Inferred from Sequence Orthology
more info
 
flavin adenine dinucleotide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
flavin adenine dinucleotide binding ISO
Inferred from Sequence Orthology
more info
 
oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
 
oxidoreductase activity, acting on the CH-CH group of donors IEA
Inferred from Electronic Annotation
more info
 
signaling receptor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
fatty acid beta-oxidation ISO
Inferred from Sequence Orthology
more info
 
fatty acid beta-oxidation using acyl-CoA oxidase IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid beta-oxidation using acyl-CoA oxidase ISO
Inferred from Sequence Orthology
more info
 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell death ISO
Inferred from Sequence Orthology
more info
 
positive regulation of response to oxidative stress ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
cytosol ISO
Inferred from Sequence Orthology
more info
 
intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peroxisome ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
peroxisomal acyl-coenzyme A oxidase 2
Names
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase
THCA-CoA oxidase
branched chain acyl-CoA oxidase
trihydroxycoprostanoyl-CoA oxidase
NP_001155139.1
NP_444345.2
XP_006518171.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161667.1NP_001155139.1  peroxisomal acyl-coenzyme A oxidase 2

    See identical proteins and their annotated locations for NP_001155139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT025547
    Consensus CDS
    CCDS36801.1
    UniProtKB/Swiss-Prot
    Q9QXD1
    Related
    ENSMUSP00000022271.7, ENSMUST00000022271.13
    Conserved Domains (2) summary
    cd01150
    Location:20655
    AXO; Peroxisomal acyl-CoA oxidase
    PLN02443
    Location:25675
    PLN02443; acyl-coenzyme A oxidase
  2. NM_053115.2NP_444345.2  peroxisomal acyl-coenzyme A oxidase 2

    See identical proteins and their annotated locations for NP_444345.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    CT025547
    Consensus CDS
    CCDS36801.1
    UniProtKB/Swiss-Prot
    Q9QXD1
    Related
    ENSMUSP00000126464.1, ENSMUST00000164598.7
    Conserved Domains (2) summary
    cd01150
    Location:20655
    AXO; Peroxisomal acyl-CoA oxidase
    PLN02443
    Location:25675
    PLN02443; acyl-coenzyme A oxidase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

    Range
    8225511..8259019 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518108.3XP_006518171.1  peroxisomal acyl-coenzyme A oxidase 2 isoform X1

    See identical proteins and their annotated locations for XP_006518171.1

    UniProtKB/Swiss-Prot
    Q9QXD1
    Conserved Domains (2) summary
    cd01150
    Location:20655
    AXO; Peroxisomal acyl-CoA oxidase
    PLN02443
    Location:25675
    PLN02443; acyl-coenzyme A oxidase
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