U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trim8 tripartite motif-containing 8 [ Mus musculus (house mouse) ]

Gene ID: 93679, updated on 22-Jan-2023

Summary

Official Symbol
Trim8provided by MGI
Official Full Name
tripartite motif-containing 8provided by MGI
Primary source
MGI:MGI:1933302
See related
Ensembl:ENSMUSG00000025034 AllianceGenome:MGI:1933302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GERP; Rnf27
Summary
Predicted to enable protein homodimerization activity and transcription coactivator activity. Involved in defense response to other organism; negative regulation of viral entry into host cell; and negative regulation of viral transcription. Acts upstream of or within positive regulation of protein localization to nucleus and stem cell population maintenance. Located in cytosol and nucleus. Is expressed in cerebellum layer; female reproductive system; and urinary system. Orthologous to human TRIM8 (tripartite motif containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 48.9), lung adult (RPKM 41.9) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Trim8 in Genome Data Viewer
Location:
19; 19 C3
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46490087..46504894)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46501648..46516805)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene ARP1 actin-related protein 1A, centractin alpha Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene ADP-ribosylation factor-like 3 Neighboring gene sideroflexin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM8; probable E3 ubiquitin-protein ligase TRIM8
Names
RING-type E3 ubiquitin transferase TRIM8
glioblastoma-expressed RING finger protein
ring finger protein 27
tripartite motif protein 8
tripartite motif-containing protein 8
NP_444330.2
XP_006527551.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053100.2NP_444330.2  E3 ubiquitin-protein ligase TRIM8

    See identical proteins and their annotated locations for NP_444330.2

    Status: VALIDATED

    Source sequence(s)
    BC082298, BM944255
    Consensus CDS
    CCDS38009.1
    UniProtKB/Swiss-Prot
    Q99PJ2, Q99PQ4
    UniProtKB/TrEMBL
    A0A8C6GX51
    Related
    ENSMUSP00000026008.8, ENSMUST00000026008.9
    Conserved Domains (3) summary
    pfam00643
    Location:140182
    zf-B_box; B-box zinc finger
    cl17238
    Location:1555
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:189257
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46490087..46504894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006527488.5XP_006527551.1  probable E3 ubiquitin-protein ligase TRIM8 isoform X1

    Conserved Domains (2) summary
    PRK03918
    Location:2158
    PRK03918; DNA double-strand break repair ATPase Rad50
    pfam09606
    Location:203343
    Med15; ARC105 or Med15 subunit of Mediator complex non-fungal