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Trim8 tripartite motif-containing 8 [ Mus musculus (house mouse) ]

Gene ID: 93679, updated on 8-Feb-2024

Summary

Official Symbol
Trim8provided by MGI
Official Full Name
tripartite motif-containing 8provided by MGI
Primary source
MGI:MGI:1933302
See related
Ensembl:ENSMUSG00000025034 AllianceGenome:MGI:1933302
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
GERP; Rnf27
Summary
Predicted to enable protein homodimerization activity and transcription coactivator activity. Involved in defense response to other organism; negative regulation of viral entry into host cell; and negative regulation of viral transcription. Acts upstream of or within positive regulation of protein localization to nucleus and stem cell population maintenance. Located in cytosol and nucleus. Is expressed in cerebellum layer; female reproductive system; and urinary system. Orthologous to human TRIM8 (tripartite motif containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 48.9), lung adult (RPKM 41.9) and 27 other tissues See more
Orthologs
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Genomic context

See Trim8 in Genome Data Viewer
Location:
19 C3; 19 38.92 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (46490087..46504894)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (46501648..46516805)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E3253 Neighboring gene ARP1 actin-related protein 1A, centractin alpha Neighboring gene STARR-positive B cell enhancer ABC_E7668 Neighboring gene STARR-positive B cell enhancer ABC_E1528 Neighboring gene SUFU negative regulator of hedgehog signaling Neighboring gene STARR-positive B cell enhancer ABC_E4288 Neighboring gene STARR-positive B cell enhancer ABC_E5708 Neighboring gene STARR-seq mESC enhancer starr_46309 Neighboring gene STARR-positive B cell enhancer ABC_E268 Neighboring gene STARR-seq mESC enhancer starr_46312 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:46592537-46592738 Neighboring gene STARR-seq mESC enhancer starr_46316 Neighboring gene ADP-ribosylation factor-like 3 Neighboring gene STARR-positive B cell enhancer ABC_E8752 Neighboring gene STARR-positive B cell enhancer mm9_chr19:46647489-46647790 Neighboring gene sideroflexin 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables mitogen-activated protein kinase kinase kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of viral transcription IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of autophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of protein localization to nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein K63-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in suppression of viral release by host IDA
Inferred from Direct Assay
more info
PubMed 
involved_in suppression of viral release by host ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in PML body ISO
Inferred from Sequence Orthology
more info
 
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIM8
Names
RING-type E3 ubiquitin transferase TRIM8
glioblastoma-expressed RING finger protein
probable E3 ubiquitin-protein ligase TRIM8
ring finger protein 27
tripartite motif protein 8
tripartite motif-containing protein 8
NP_001411955.1
NP_444330.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425026.1NP_001411955.1  E3 ubiquitin-protein ligase TRIM8 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC156982
  2. NM_053100.2NP_444330.2  E3 ubiquitin-protein ligase TRIM8 isoform 1

    See identical proteins and their annotated locations for NP_444330.2

    Status: VALIDATED

    Source sequence(s)
    BC082298, BM944255
    Consensus CDS
    CCDS38009.1
    UniProtKB/Swiss-Prot
    Q3U2G3, Q8C508, Q8C700, Q8CGI2, Q99PJ2, Q99PQ4
    Related
    ENSMUSP00000026008.8, ENSMUST00000026008.9
    Conserved Domains (3) summary
    pfam00643
    Location:140182
    zf-B_box; B-box zinc finger
    cl17238
    Location:1555
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
    cl23765
    Location:189257
    iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    46490087..46504894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)