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ITGBL1 integrin subunit beta like 1 [ Homo sapiens (human) ]

Gene ID: 9358, updated on 11-Sep-2019

Summary

Official Symbol
ITGBL1provided by HGNC
Official Full Name
integrin subunit beta like 1provided by HGNC
Primary source
HGNC:HGNC:6164
See related
Ensembl:ENSG00000198542 MIM:604234
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OSCP; TIED
Summary
This gene encodes a beta integrin-related protein that is a member of the EGF-like protein family. The encoded protein contains integrin-like cysteine-rich repeats. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Expression
Broad expression in gall bladder (RPKM 11.4), lung (RPKM 9.5) and 18 other tissues See more
Orthologs

Genomic context

See ITGBL1 in Genome Data Viewer
Location:
13q33.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 13 NC_000013.11 (101452593..101720856)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (102104944..102373207)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene NALCN antisense RNA 1 Neighboring gene long intergenic non-protein coding RNA 411 Neighboring gene sodium leak channel, non-selective Neighboring gene uncharacterized LOC107984616 Neighboring gene fibroblast growth factor 14 Neighboring gene RNA, U1 small nuclear 24, pseudogene Neighboring gene high mobility group box 3 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
NHGRI GWA Catalog
Genome-wide association study of atypical psychosis.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell adhesion mediated by integrin IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin-mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell surface IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region IEA
Inferred from Electronic Annotation
more info
 
focal adhesion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integrin complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
integrin beta-like protein 1
Names
integrin beta like 1
integrin, beta-like 1 (with EGF-like repeat domains)
osteoblast-specific cysteine-rich protein
ten integrin EGF-like repeat domain-containing protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271754.2NP_001258683.1  integrin beta-like protein 1 isoform 4

    See identical proteins and their annotated locations for NP_001258683.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 5' coding region, differs in the 3' UTR, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
    Source sequence(s)
    AK026784, AK297744, AL160153, AL359052, AL527690, BC036788, BQ014290, CD110646, DA863037
    Consensus CDS
    CCDS61362.1
    UniProtKB/Swiss-Prot
    O95965
    UniProtKB/TrEMBL
    B4DN32
    Related
    ENSP00000439903.1, ENST00000545560.6
  2. NM_001271755.1NP_001258684.1  integrin beta-like protein 1 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AK308194, AL160153, BC036788, BP284376, CA436890, EL948537
    Consensus CDS
    CCDS73594.1
    UniProtKB/Swiss-Prot
    O95965
    UniProtKB/TrEMBL
    A0A087WY35
    Related
    ENSP00000481484.1, ENST00000618057.4
  3. NM_001271756.1NP_001258685.1  integrin beta-like protein 1 isoform 3

    See identical proteins and their annotated locations for NP_001258685.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and represents use of an alternate promoter, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AK298571, AL160153, BC036788
    Consensus CDS
    CCDS61361.1
    UniProtKB/Swiss-Prot
    O95965
    Related
    ENSP00000365332.3, ENST00000376162.7
  4. NM_004791.3NP_004782.1  integrin beta-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004782.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL139800, AL160153, AL355807
    Consensus CDS
    CCDS9499.1
    UniProtKB/Swiss-Prot
    O95965
    UniProtKB/TrEMBL
    A0A024RDW7
    Related
    ENSP00000365351.3, ENST00000376180.8

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p13 Primary Assembly

    Range
    101452593..101720856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254100.5XP_005254157.1  integrin beta-like protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005254157.1

    UniProtKB/Swiss-Prot
    O95965
    UniProtKB/TrEMBL
    A0A024RDW7
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