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ZFAND4 zinc finger AN1-type containing 4 [ Homo sapiens (human) ]

Gene ID: 93550, updated on 3-Nov-2024

Summary

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Official Symbol
ZFAND4provided by HGNC
Official Full Name
zinc finger AN1-type containing 4provided by HGNC
Primary source
HGNC:HGNC:23504
See related
Ensembl:ENSG00000172671 AllianceGenome:HGNC:23504
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANUBL1
Summary
Predicted to enable zinc ion binding activity. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in testis (RPKM 26.4), lymph node (RPKM 2.8) and 9 other tissues See more
Orthologs
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Genomic context

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See ZFAND4 in Genome Data Viewer
Location:
10q11.22
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (45615500..45672813, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (46496511..46553811, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (46110948..46168261, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene arachidonate 5-lipoxygenase Neighboring gene uncharacterized LOC102724323 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:45958734-45959933 Neighboring gene uncharacterized LOC105378286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45970297-45970798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45970799-45971298 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45998823-45999323 Neighboring gene VISTA enhancer hs2065 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:46070300-46070960 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:46086550-46087050 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2344 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2345 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3322 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2347 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 10, pseudogene Neighboring gene family with sequence similarity 21 member F, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma. Kurihara-Shimomura M, et al. J Clin Pathol, 2018 May. PMID 29074611
  2. MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer. Tang L, et al. Oncol Rep, 2015 Apr. PMID 25682742
  3. E3 ubiquitin ligase FBXO22 inhibits SARS-CoV-2 replication via promoting proteasome-dependent degradation of NSP5. Zhou Y, et al. J Med Virol, 2024 Sep. PMID 39223933
  4. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  5. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. Grupe A, et al. Am J Hum Genet, 2006 Jan. PMID 16385451, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Suggest that ZFAND4 is a useful marker for predicting metastasis and poor prognosis in patients with oral squamous cell carcinoma.
    Title: Zinc finger AN1-type containing 4 is a novel marker for predicting metastasis and poor prognosis in oral squamous cell carcinoma.
  2. In gastric cancer cells, ANUBL1 was upregulated and promoted proliferation of SGC-7901 cells. Over-expression decreased miR-182 expression. ANUBL1 expression was in turn directly downregulated by miR-182 in a negative feedback loop.
    Title: MicroRNA-182 inhibits proliferation through targeting oncogenic ANUBL1 in gastric cancer.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ40185

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
AN1-type zinc finger protein 4
Names
AN1, ubiquitin-like, homolog
AN1-type zinc finger and ubiquitin domain-containing protein 1
AN1-type zinc finger and ubiquitin domain-containing protein-like 1
zinc finger, AN1-type domain 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128324.2 → NP_001121796.1  AN1-type zinc finger protein 4 isoform a

    See identical proteins and their annotated locations for NP_001121796.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC045587, DB522994
    Consensus CDS
    CCDS7214.1
    UniProtKB/Swiss-Prot
    A8K8V4, B2RAX2, Q5VVY5, Q86XD8
    UniProtKB/TrEMBL
    A8K8Q5
    Conserved Domains (3) summary
    cd01802
    Location:1 → 103
    AN1_N; ubiquitin-like domain of AN1
    smart00154
    Location:667 → 705
    ZnF_AN1; AN1-like Zinc finger
    smart00213
    Location:28 → 99
    UBQ; Ubiquitin homologues

  2. NM_001282905.1 → NP_001269834.1  AN1-type zinc finger protein 4 isoform b

    See identical proteins and their annotated locations for NP_001269834.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in its 5' region and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AF311324, AK292420, BC048968, DB454939, DB456684, DB522994
    Consensus CDS
    CCDS60520.1
    UniProtKB/TrEMBL
    A8K8Q5, J3KPC0
    Related
    ENSP00000363486.3, ENST00000374366.7
    Conserved Domains (2) summary
    smart00154
    Location:593 → 631
    ZnF_AN1; AN1-like Zinc finger
    cl00155
    Location:1 → 29
    UBQ; Ubiquitin-like proteins

  3. NM_001282906.1 → NP_001269835.1  AN1-type zinc finger protein 4 isoform b

    See identical proteins and their annotated locations for NP_001269835.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon in its 5' region and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AF311324, AK292420, BC045587, DB522994
    Consensus CDS
    CCDS60520.1
    UniProtKB/TrEMBL
    A8K8Q5, J3KPC0
    Conserved Domains (2) summary
    smart00154
    Location:593 → 631
    ZnF_AN1; AN1-like Zinc finger
    cl00155
    Location:1 → 29
    UBQ; Ubiquitin-like proteins

  4. NM_174890.4 → NP_777550.2  AN1-type zinc finger protein 4 isoform a

    See identical proteins and their annotated locations for NP_777550.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AF311324, AL445201, BC048968, DB454939, DB456684, DB522994
    Consensus CDS
    CCDS7214.1
    UniProtKB/Swiss-Prot
    A8K8V4, B2RAX2, Q5VVY5, Q86XD8
    UniProtKB/TrEMBL
    A8K8Q5
    Related
    ENSP00000339484.5, ENST00000344646.10
    Conserved Domains (3) summary
    cd01802
    Location:1 → 103
    AN1_N; ubiquitin-like domain of AN1
    smart00154
    Location:667 → 705
    ZnF_AN1; AN1-like Zinc finger
    smart00213
    Location:28 → 99
    UBQ; Ubiquitin homologues

RNA

  1. NR_104256.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses a different 5' terminal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK292420, BC017591, BC045587, CR741609
    Related
    ENST00000465407.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    45615500..45672813 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016939.3 → XP_016872428.1  AN1-type zinc finger protein 4 isoform X8

    UniProtKB/TrEMBL
    B3KUL6
    Conserved Domains (2) summary
    smart00154
    Location:619 → 657
    ZnF_AN1; AN1-like Zinc finger
    cl00155
    Location:1 → 61
    UBQ; Ubiquitin-like proteins

  2. XM_017016933.3 → XP_016872422.1  AN1-type zinc finger protein 4 isoform X5

    UniProtKB/TrEMBL
    A8K8Q5

  3. XM_047426012.1 → XP_047281968.1  AN1-type zinc finger protein 4 isoform X5

  4. XM_047426014.1 → XP_047281970.1  AN1-type zinc finger protein 4 isoform X8

  5. XM_047426011.1 → XP_047281967.1  AN1-type zinc finger protein 4 isoform X5

  6. XM_047426010.1 → XP_047281966.1  AN1-type zinc finger protein 4 isoform X5

  7. XM_011540366.3 → XP_011538668.1  AN1-type zinc finger protein 4 isoform X4

    UniProtKB/TrEMBL
    B3KUL6
    Conserved Domains (2) summary
    smart00154
    Location:675 → 713
    ZnF_AN1; AN1-like Zinc finger
    cl00155
    Location:57 → 117
    UBQ; Ubiquitin-like proteins

  8. XM_047426009.1 → XP_047281965.1  AN1-type zinc finger protein 4 isoform X2

  9. XM_047426008.1 → XP_047281964.1  AN1-type zinc finger protein 4 isoform X1

  10. XM_047426017.1 → XP_047281973.1  AN1-type zinc finger protein 4 isoform X5

  11. XM_017016931.2 → XP_016872420.1  AN1-type zinc finger protein 4 isoform X3

    UniProtKB/TrEMBL
    B3KUL6

  12. XM_047426016.1 → XP_047281972.1  AN1-type zinc finger protein 4 isoform X11

  13. XM_017016940.3 → XP_016872429.1  AN1-type zinc finger protein 4 isoform X9

    UniProtKB/TrEMBL
    A8K8Q5

  14. XM_011540368.2 → XP_011538670.1  AN1-type zinc finger protein 4 isoform X12

    UniProtKB/TrEMBL
    B3KUL6
    Conserved Domains (1) summary
    smart00154
    Location:495 → 533
    ZnF_AN1; AN1-like Zinc finger

  15. XM_047426018.1 → XP_047281974.1  AN1-type zinc finger protein 4 isoform X13

  16. XM_047426015.1 → XP_047281971.1  AN1-type zinc finger protein 4 isoform X10

  17. XM_047426013.1 → XP_047281969.1  AN1-type zinc finger protein 4 isoform X7

  18. XM_017016935.2 → XP_016872424.2  AN1-type zinc finger protein 4 isoform X6

RNA

  1. XR_001747259.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    46496511..46553811 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054367182.1 → XP_054223157.1  AN1-type zinc finger protein 4 isoform X8

  2. XM_054367177.1 → XP_054223152.1  AN1-type zinc finger protein 4 isoform X5

  3. XM_054367176.1 → XP_054223151.1  AN1-type zinc finger protein 4 isoform X4

  4. XM_054367174.1 → XP_054223149.1  AN1-type zinc finger protein 4 isoform X2

  5. XM_054367173.1 → XP_054223148.1  AN1-type zinc finger protein 4 isoform X1

  6. XM_054367178.1 → XP_054223153.1  AN1-type zinc finger protein 4 isoform X5

  7. XM_054367179.1 → XP_054223154.1  AN1-type zinc finger protein 4 isoform X5

  8. XM_054367183.1 → XP_054223158.1  AN1-type zinc finger protein 4 isoform X8

  9. XM_054367187.1 → XP_054223162.1  AN1-type zinc finger protein 4 isoform X5

  10. XM_054367175.1 → XP_054223150.1  AN1-type zinc finger protein 4 isoform X3

  11. XM_054367186.1 → XP_054223161.1  AN1-type zinc finger protein 4 isoform X11

  12. XM_054367184.1 → XP_054223159.1  AN1-type zinc finger protein 4 isoform X9

  13. XM_054367188.1 → XP_054223163.1  AN1-type zinc finger protein 4 isoform X12

  14. XM_054367189.1 → XP_054223164.1  AN1-type zinc finger protein 4 isoform X13

  15. XM_054367185.1 → XP_054223160.1  AN1-type zinc finger protein 4 isoform X10

  16. XM_054367181.1 → XP_054223156.1  AN1-type zinc finger protein 4 isoform X7

  17. XM_054367180.1 → XP_054223155.1  AN1-type zinc finger protein 4 isoform X6

RNA

  1. XR_008488312.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86XD8.2 GenPept UniProtKB/Swiss-Prot:Q86XD8

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