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ZFAND4 zinc finger AN1-type containing 4 [ Homo sapiens (human) ]

Gene ID: 93550, updated on 21-Dec-2019

Summary

Official Symbol
ZFAND4provided by HGNC
Official Full Name
zinc finger AN1-type containing 4provided by HGNC
Primary source
HGNC:HGNC:23504
See related
Ensembl:ENSG00000172671
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ANUBL1
Expression
Biased expression in testis (RPKM 26.4), lymph node (RPKM 2.8) and 9 other tissues See more
Orthologs

Genomic context

See ZFAND4 in Genome Data Viewer
Location:
10q11.22
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (45614567..45672962, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (46111039..46168251, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378286 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene VISTA enhancer hs2065 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 10, pseudogene Neighboring gene family with sequence similarity 21 member F, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ40185

Gene Ontology Provided by GOA

Function Evidence Code Pubs
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
AN1-type zinc finger protein 4
Names
AN1, ubiquitin-like, homolog
AN1-type zinc finger and ubiquitin domain-containing protein 1
AN1-type zinc finger and ubiquitin domain-containing protein-like 1
zinc finger, AN1-type domain 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001128324.2NP_001121796.1  AN1-type zinc finger protein 4 isoform a

    See identical proteins and their annotated locations for NP_001121796.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    BC045587, DB522994
    Consensus CDS
    CCDS7214.1
    UniProtKB/Swiss-Prot
    Q86XD8
    UniProtKB/TrEMBL
    A0A024R7V9
    Conserved Domains (3) summary
    cd01802
    Location:1103
    AN1_N; ubiquitin-like domain of AN1
    smart00154
    Location:667705
    ZnF_AN1; AN1-like Zinc finger
    smart00213
    Location:2899
    UBQ; Ubiquitin homologues
  2. NM_001282905.1NP_001269834.1  AN1-type zinc finger protein 4 isoform b

    See identical proteins and their annotated locations for NP_001269834.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in its 5' region and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AF311324, AK292420, BC048968, DB454939, DB456684, DB522994
    Consensus CDS
    CCDS60520.1
    UniProtKB/TrEMBL
    A8K8Q5, J3KPC0, Q86WR3
    Related
    ENSP00000363486.3, ENST00000374366.7
    Conserved Domains (2) summary
    smart00154
    Location:593631
    ZnF_AN1; AN1-like Zinc finger
    cl00155
    Location:129
    UBQ; Ubiquitin-like proteins
  3. NM_001282906.1NP_001269835.1  AN1-type zinc finger protein 4 isoform b

    See identical proteins and their annotated locations for NP_001269835.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, contains an alternate exon in its 5' region and uses a downstream start codon compared to variant 1. It encodes isoform b which has a shorter N-terminus compared to isoform a. Variants 3 and 4 encode the same isoform (b).
    Source sequence(s)
    AF311324, AK292420, BC045587, DB522994
    Consensus CDS
    CCDS60520.1
    UniProtKB/Swiss-Prot
    Q86XD8
    UniProtKB/TrEMBL
    A8K8Q5, J3KPC0
    Conserved Domains (2) summary
    smart00154
    Location:593631
    ZnF_AN1; AN1-like Zinc finger
    cl00155
    Location:129
    UBQ; Ubiquitin-like proteins
  4. NM_174890.4NP_777550.2  AN1-type zinc finger protein 4 isoform a

    See identical proteins and their annotated locations for NP_777550.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a). Variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AF311324, AL445201, BC048968, DB454939, DB456684, DB522994
    Consensus CDS
    CCDS7214.1
    UniProtKB/Swiss-Prot
    Q86XD8
    UniProtKB/TrEMBL
    A0A024R7V9, Q86WR3
    Related
    ENSP00000339484.5, ENST00000344646.10
    Conserved Domains (3) summary
    cd01802
    Location:1103
    AN1_N; ubiquitin-like domain of AN1
    smart00154
    Location:667705
    ZnF_AN1; AN1-like Zinc finger
    smart00213
    Location:2899
    UBQ; Ubiquitin homologues

RNA

  1. NR_104256.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses a different 5' terminal exon and contains an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK292420, BC017591, BC045587, CR741609
    Related
    ENST00000465407.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    45614567..45672962 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016934.1XP_016872423.1  AN1-type zinc finger protein 4 isoform X3

  2. XM_017016943.1XP_016872432.1  AN1-type zinc finger protein 4 isoform X8

  3. XM_017016939.2XP_016872428.1  AN1-type zinc finger protein 4 isoform X6

    Conserved Domains (2) summary
    smart00154
    Location:619657
    ZnF_AN1; AN1-like Zinc finger
    cl00155
    Location:161
    UBQ; Ubiquitin-like proteins
  4. XM_017016938.2XP_016872427.1  AN1-type zinc finger protein 4 isoform X6

    Conserved Domains (2) summary
    smart00154
    Location:619657
    ZnF_AN1; AN1-like Zinc finger
    cl00155
    Location:161
    UBQ; Ubiquitin-like proteins
  5. XM_017016940.2XP_016872429.1  AN1-type zinc finger protein 4 isoform X7

  6. XM_017016933.2XP_016872422.1  AN1-type zinc finger protein 4 isoform X3

  7. XM_017016946.2XP_016872435.1  AN1-type zinc finger protein 4 isoform X13

  8. XM_005271842.2XP_005271899.1  AN1-type zinc finger protein 4 isoform X9

    See identical proteins and their annotated locations for XP_005271899.1

    Conserved Domains (1) summary
    smart00154
    Location:568606
    ZnF_AN1; AN1-like Zinc finger
  9. XM_017016944.1XP_016872433.1  AN1-type zinc finger protein 4 isoform X8

  10. XM_017016941.1XP_016872430.1  AN1-type zinc finger protein 4 isoform X7

  11. XM_017016937.2XP_016872426.1  AN1-type zinc finger protein 4 isoform X5

  12. XM_024448259.1XP_024304027.1  AN1-type zinc finger protein 4 isoform X10

    Conserved Domains (1) summary
    smart00154
    Location:555593
    ZnF_AN1; AN1-like Zinc finger
  13. XM_017016936.2XP_016872425.1  AN1-type zinc finger protein 4 isoform X5

  14. XM_005271844.4XP_005271901.1  AN1-type zinc finger protein 4 isoform X11

    Conserved Domains (1) summary
    smart00154
    Location:549587
    ZnF_AN1; AN1-like Zinc finger
  15. XM_005271843.2XP_005271900.1  AN1-type zinc finger protein 4 isoform X9

    See identical proteins and their annotated locations for XP_005271900.1

    Conserved Domains (1) summary
    smart00154
    Location:568606
    ZnF_AN1; AN1-like Zinc finger
  16. XM_017016942.1XP_016872431.1  AN1-type zinc finger protein 4 isoform X8

  17. XM_024448260.1XP_024304028.1  AN1-type zinc finger protein 4 isoform X10

    Conserved Domains (1) summary
    smart00154
    Location:555593
    ZnF_AN1; AN1-like Zinc finger
  18. XM_017016932.1XP_016872421.1  AN1-type zinc finger protein 4 isoform X3

  19. XM_017016931.1XP_016872420.1  AN1-type zinc finger protein 4 isoform X1

  20. XM_011540366.2XP_011538668.1  AN1-type zinc finger protein 4 isoform X2

    Conserved Domains (2) summary
    smart00154
    Location:675713
    ZnF_AN1; AN1-like Zinc finger
    cl00155
    Location:57117
    UBQ; Ubiquitin-like proteins
  21. XM_011540368.1XP_011538670.1  AN1-type zinc finger protein 4 isoform X12

    Conserved Domains (1) summary
    smart00154
    Location:495533
    ZnF_AN1; AN1-like Zinc finger
  22. XM_017016935.1XP_016872424.1  AN1-type zinc finger protein 4 isoform X4

RNA

  1. XR_001747265.1 RNA Sequence

  2. XR_001747262.1 RNA Sequence

  3. XR_001747264.1 RNA Sequence

  4. XR_001747261.2 RNA Sequence

  5. XR_001747263.1 RNA Sequence

  6. XR_001747260.1 RNA Sequence

  7. XR_001747259.1 RNA Sequence

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