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TXNL1 thioredoxin like 1 [ Homo sapiens (human) ]

Gene ID: 9352, updated on 6-Sep-2022

Summary

Official Symbol
TXNL1provided by HGNC
Official Full Name
thioredoxin like 1provided by HGNC
Primary source
HGNC:HGNC:12436
See related
Ensembl:ENSG00000091164 MIM:603049; AllianceGenome:HGNC:12436
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Txl; TXNL; TRP32; TXL-1; HEL-S-114
Summary
Enables disulfide oxidoreductase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 57.8), testis (RPKM 14.4) and 25 other tissues See more
Orthologs
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Genomic context

See TXNL1 in Genome Data Viewer
Location:
18q21.31
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (56597209..56638592, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (56799245..56840564, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (54264440..54305823, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC642484 Neighboring gene uncharacterized LOC105372132 Neighboring gene uncharacterized LOC105372135 Neighboring gene Sharpr-MPRA regulatory region 10710 Neighboring gene WD repeat domain 7 Neighboring gene small nucleolar RNA U3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette's Syndrome and OCD.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables disulfide oxidoreductase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables thioredoxin-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
part_of proteasome complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
thioredoxin-like protein 1
Names
32 kDa thioredoxin-related protein
epididymis secretory protein Li 114
thioredoxin-related 32 kDa protein
thioredoxin-related protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004786.3NP_004777.1  thioredoxin-like protein 1

    See identical proteins and their annotated locations for NP_004777.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the protein coding transcript.
    Source sequence(s)
    AC007052, AF003938, AV750604
    Consensus CDS
    CCDS11961.1
    UniProtKB/Swiss-Prot
    O43396
    UniProtKB/TrEMBL
    V9HW51
    Related
    ENSP00000217515.5, ENST00000217515.11
    Conserved Domains (2) summary
    cd02947
    Location:12104
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    pfam06201
    Location:128268
    PITH; PITH domain

RNA

  1. NR_024546.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an additional exon compared to transcript variant 1. This results in a frame-shift and premature translation termination, rendering the transcript susceptible to nonsense mediated mRNA decay (NMD). This transcript is sufficiently abundant to represent as a RefSeq record, however, the predicted protein is not represented because it is significantly truncated.
    Source sequence(s)
    AC007052, AF003938, AV750604, DA248363

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    56597209..56638592 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451289.2XP_024307057.1  thioredoxin-like protein 1 isoform X1

    Conserved Domains (2) summary
    cd02947
    Location:12104
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    pfam06201
    Location:128268
    PITH; PITH domain
  2. XM_024451290.2XP_024307058.1  thioredoxin-like protein 1 isoform X2

    Related
    ENSP00000468165.1, ENST00000586262.5
    Conserved Domains (2) summary
    cd02947
    Location:12104
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    pfam06201
    Location:128268
    PITH; PITH domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    56799245..56840564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)