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MGAM2 maltase-glucoamylase 2 (putative) [ Homo sapiens (human) ]

Gene ID: 93432, updated on 5-Jan-2022

Summary

Official Symbol
MGAM2provided by HGNC
Official Full Name
maltase-glucoamylase 2 (putative)provided by HGNC
Primary source
HGNC:HGNC:28101
See related
Ensembl:ENSG00000257743
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable alpha-1,4-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in duodenum (RPKM 13.7), small intestine (RPKM 11.0) and 5 other tissues See more
Orthologs
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Genomic context

See MGAM2 in Genome Data Viewer
Location:
7q34
Exon count:
49
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (142111703..142223733)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (141811518..141922124)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene taste 2 receptor member 38 Neighboring gene maltase-glucoamylase Neighboring gene monooxygenase DBH like 2, pseudogene Neighboring gene serine protease 58

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ16351, MGC138178, MGC138180

General protein information

Preferred Names
putative maltase-glucoamylase-like protein FLJ16351
Names
Putative maltase-glucoamylase-like protein FLJ16351
maltase-glucoamylase (alpha-glucosidase)
NP_001280555.1
XP_011514994.1
XP_011514995.1
XP_011514996.1
XP_024302765.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001293626.2NP_001280555.1  putative maltase-glucoamylase-like protein FLJ16351

    See identical proteins and their annotated locations for NP_001280555.1

    Status: VALIDATED

    Source sequence(s)
    AC091742
    Consensus CDS
    CCDS78281.1
    UniProtKB/Swiss-Prot
    Q2M2H8
    Related
    ENSP00000420449.3, ENST00000477922.4
    Conserved Domains (6) summary
    PHA03255
    Location:18191965
    PHA03255; BDLF3; Provisional
    cd06602
    Location:323680
    GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
    cd14752
    Location:207323
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam00088
    Location:907948
    Trefoil; Trefoil (P-type) domain
    pfam01055
    Location:304769
    Glyco_hydro_31; Glycosyl hydrolases family 31
    pfam16863
    Location:104214
    NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    142111703..142223733
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446997.1XP_024302765.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X4

    Conserved Domains (6) summary
    smart00018
    Location:908948
    PD; P or trefoil or TFF domain
    cd14752
    Location:207323
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam00088
    Location:4386
    Trefoil; Trefoil (P-type) domain
    pfam01055
    Location:304769
    Glyco_hydro_31; Glycosyl hydrolases family 31
    pfam16863
    Location:104214
    NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
    cl25582
    Location:11711229
    Glyco_hydro_31; Glycosyl hydrolases family 31
  2. XM_011516692.2XP_011514994.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X1

    See identical proteins and their annotated locations for XP_011514994.1

    Conserved Domains (6) summary
    PHA03255
    Location:15491695
    PHA03255; BDLF3; Provisional
    cd06602
    Location:53410
    GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
    cd14752
    Location:806920
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam00088
    Location:637678
    Trefoil; Trefoil (P-type) domain
    pfam01055
    Location:34499
    Glyco_hydro_31; Glycosyl hydrolases family 31
    pfam16863
    Location:721813
    NtCtMGAM_N; N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase
  3. XM_011516693.2XP_011514995.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X2

    See identical proteins and their annotated locations for XP_011514995.1

    Conserved Domains (5) summary
    smart00018
    Location:5393
    PD; P or trefoil or TFF domain
    PRK10856
    Location:10371110
    PRK10856; cytoskeleton protein RodZ
    cd06602
    Location:335726
    GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
    cd14752
    Location:221335
    GH31_N; N-terminal domain of glycosyl hydrolase family 31 (GH31)
    pfam05109
    Location:12041613
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
  4. XM_011516694.2XP_011514996.1  putative maltase-glucoamylase-like protein FLJ16351 isoform X3

    See identical proteins and their annotated locations for XP_011514996.1

    Conserved Domains (2) summary
    cd06602
    Location:1343
    GH31_MGAM_SI_GAA; maltase-glucoamylase, sucrase-isomaltase, lysosomal acid alpha-glucosidase
    pfam01055
    Location:1433
    Glyco_hydro_31; Glycosyl hydrolases family 31

RNA

  1. XR_927547.2 RNA Sequence

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187562.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    73598..184204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_026640.1: Suppressed sequence

    Description
    NG_026640.1: This RefSeq was permanently suppressed because it is now thought that this pseudogene is transcribed.
  2. NM_001008748.2: Suppressed sequence

    Description
    NM_001008748.2: This RefSeq was suppressed temporarily because the source transcript appears to be partial (the encoded protein is not consistent with other maltases) and an alternate source was not identified.
  3. NR_003715.1: Suppressed sequence

    Description
    NR_003715.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
  4. NR_003717.1: Suppressed sequence

    Description
    NR_003717.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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