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TRIP12 thyroid hormone receptor interactor 12 [ Homo sapiens (human) ]

Gene ID: 9320, updated on 4-Nov-2018

Summary

Official Symbol
TRIP12provided by HGNC
Official Full Name
thyroid hormone receptor interactor 12provided by HGNC
Primary source
HGNC:HGNC:12306
See related
Ensembl:ENSG00000153827 MIM:604506; Vega:OTTHUMG00000153623
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ULF; MRD49; TRIP-12
Summary
The protein encoded by this gene is an E3 ubiquitin-protein ligase involved in the degradation of the p19ARF/ARF isoform of CDKN2A, a tumor suppressor. The encoded protein also plays a role in the DNA damage response by regulating the stability of USP7, which regulates tumor suppressor p53. [provided by RefSeq, Jan 2017]
Expression
Broad expression in testis (RPKM 48.5), thyroid (RPKM 17.6) and 24 other tissues See more
Orthologs

Genomic context

See TRIP12 in Genome Data Viewer
Location:
2q36.3
Exon count:
50
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (229763837..229923234, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (230631098..230786763, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene delta/notch like EGF repeat containing Neighboring gene uncharacterized LOC105373923 Neighboring gene RNA, U7 small nuclear 9 pseudogene Neighboring gene RNA, U6 small nuclear 613, pseudogene Neighboring gene uncharacterized LOC105373924 Neighboring gene RNA, U6 small nuclear 964, pseudogene Neighboring gene F-box protein 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
MENTAL RETARDATION, AUTOSOMAL DOMINANT 49
MedGen: C4540324 OMIM: 617752 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated (2018-04-02)

ClinGen Genome Curation Page
Haploinsufficency

Sufficient evidence for dosage pathogenicity (Last evaluated (2018-04-02)

ClinGen Genome Curation PagePubMed

Pathways from BioSystems

  • Adaptive Immune System, organism-specific biosystem (from REACTOME)
    Adaptive Immune System, organism-specific biosystemAdaptive immunity refers to antigen-specific immune response efficiently involved in clearing the pathogens. The adaptive immune system is comprised of B and T lymphocytes that express receptors with...
  • Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystem (from REACTOME)
    Antigen processing: Ubiquitination & Proteasome degradation, organism-specific biosystemIntracellular foreign or aberrant host proteins are cleaved into peptide fragments of a precise size, such that they can be loaded on to class I MHC molecules and presented externally to cytotoxic T ...
  • Class I MHC mediated antigen processing & presentation, organism-specific biosystem (from REACTOME)
    Class I MHC mediated antigen processing & presentation, organism-specific biosystemMajor histocompatibility complex (MHC) class I molecules play an important role in cell mediated immunity by reporting on intracellular events such as viral infection, the presence of intracellular b...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Ubiquitin mediated proteolysis, organism-specific biosystem (from KEGG)
    Ubiquitin mediated proteolysis, organism-specific biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...
  • Ubiquitin mediated proteolysis, conserved biosystem (from KEGG)
    Ubiquitin mediated proteolysis, conserved biosystemProtein ubiquitination plays an important role in eukaryotic cellular processes. It mainly functions as a signal for 26S proteasome dependent protein degradation. The addition of ubiquitin to protein...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ46626, KIAA0045, MGC138849, MGC138850

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
thyroid hormone receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity EXP
Inferred from Experiment
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-protein transferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
ubiquitin-protein transferase activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
DNA repair IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to DNA damage stimulus IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of double-strand break repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of histone H2A K63-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of histone H2A K63-linked ubiquitination IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus HDA PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase TRIP12
Names
E3 ubiquitin-protein ligase for Arf
HECT-type E3 ubiquitin transferase TRIP12
TR-interacting protein 12
probable E3 ubiquitin-protein ligase TRIP12
thyroid receptor interacting protein 12
NP_001271143.1
NP_001271144.1
NP_001271145.1
NP_001335244.1
NP_001335245.1
NP_001335246.1
NP_001335247.1
NP_001335248.1
NP_001335249.1
NP_001335250.1
NP_001335251.1
NP_001335252.1
NP_001335253.1
NP_001335254.1
NP_001335255.1
NP_001335256.1
NP_001335257.1
NP_001335258.1
NP_001335259.1
NP_001335260.1
NP_001335261.1
NP_001335262.1
NP_001335263.1
NP_001335264.1
NP_001335265.1
NP_004229.1
XP_005247018.1
XP_016860772.1
XP_016860778.1
XP_016860779.1
XP_024308991.1
XP_024308992.1
XP_024308993.1
XP_024308994.1
XP_024308995.1
XP_024308996.1
XP_024308997.1
XP_024308998.1
XP_024308999.1
XP_024309000.1
XP_024309001.1
XP_024309002.1
XP_024309003.1
XP_024309004.1
XP_024309005.1
XP_024309006.1
XP_024309007.1
XP_024309008.1
XP_024309009.1
XP_024309010.1
XP_024309011.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_053017.1 RefSeqGene

    Range
    6226..164398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001284214.1NP_001271143.1  E3 ubiquitin-protein ligase TRIP12 isoform a

    See identical proteins and their annotated locations for NP_001271143.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variant 5, encodes isoform a.
    Source sequence(s)
    AC093384, BC114556, BM677880, D28476, DB240964
    Consensus CDS
    CCDS63146.1
    UniProtKB/Swiss-Prot
    Q14669
    Related
    ENSP00000373696.4, OTTHUMP00000204209, ENST00000389044.8, OTTHUMT00000331864
    Conserved Domains (4) summary
    cd00078
    Location:16382038
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808846
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  2. NM_001284215.2NP_001271144.1  E3 ubiquitin-protein ligase TRIP12 isoform b

    See identical proteins and their annotated locations for NP_001271144.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variant 6, encodes isoform b.
    Source sequence(s)
    AC009973, AC093384, AC105380
    UniProtKB/Swiss-Prot
    Q14669
    Conserved Domains (4) summary
    cd00078
    Location:16232023
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766831
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  3. NM_001284216.1NP_001271145.1  E3 ubiquitin-protein ligase TRIP12 isoform d

    See identical proteins and their annotated locations for NP_001271145.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes isoform d.
    Source sequence(s)
    AC093384, BC113891, BM677880, D28476, DB240964
    Consensus CDS
    CCDS63145.1
    UniProtKB/Swiss-Prot
    Q14669
    Related
    ENSP00000373697.3, OTTHUMP00000204210, ENST00000389045.7, OTTHUMT00000331865
    Conserved Domains (3) summary
    smart00119
    Location:13381716
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:13201720
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:463528
    WWE; WWE domain
  4. NM_001348315.1NP_001335244.1  E3 ubiquitin-protein ligase TRIP12 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variant 1, encodes isoform a.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Consensus CDS
    CCDS63146.1
    UniProtKB/Swiss-Prot
    Q14669
    Conserved Domains (4) summary
    cd00078
    Location:16382038
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808846
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  5. NM_001348316.1NP_001335245.1  E3 ubiquitin-protein ligase TRIP12 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variant 2, encodes isoform b.
    Source sequence(s)
    AC009973, AC093384, AC105380
    UniProtKB/Swiss-Prot
    Q14669
    Conserved Domains (4) summary
    cd00078
    Location:16232023
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766831
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  6. NM_001348317.1NP_001335246.1  E3 ubiquitin-protein ligase TRIP12 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variant 8, encodes isoform e.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16182018
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766831
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  7. NM_001348318.1NP_001335247.1  E3 ubiquitin-protein ligase TRIP12 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 7, encodes isoform e.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16182018
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766831
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  8. NM_001348319.1NP_001335248.1  E3 ubiquitin-protein ligase TRIP12 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 10, encodes isoform f.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16602060
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808873
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  9. NM_001348320.1NP_001335249.1  E3 ubiquitin-protein ligase TRIP12 isoform f

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 9, encodes isoform f.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16602060
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808873
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  10. NM_001348321.1NP_001335250.1  E3 ubiquitin-protein ligase TRIP12 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) encodes isoform g.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16612061
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808874
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  11. NM_001348322.1NP_001335251.1  E3 ubiquitin-protein ligase TRIP12 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 13-17, encodes isoform h.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16652065
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808873
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  12. NM_001348323.1NP_001335252.1  E3 ubiquitin-protein ligase TRIP12 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 12 and 14-17, encodes isoform h.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16652065
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808873
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  13. NM_001348324.1NP_001335253.1  E3 ubiquitin-protein ligase TRIP12 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 12-13 and 15-17, encodes isoform h.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16652065
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808873
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  14. NM_001348325.1NP_001335254.1  E3 ubiquitin-protein ligase TRIP12 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 12-14 and 16-17, encodes isoform h.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16652065
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808873
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  15. NM_001348326.1NP_001335255.1  E3 ubiquitin-protein ligase TRIP12 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 12-15 and 17, encodes isoform h.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16652065
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808873
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  16. NM_001348327.1NP_001335256.1  E3 ubiquitin-protein ligase TRIP12 isoform h

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 12-16, encodes isoform h.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16652065
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808873
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  17. NM_001348328.1NP_001335257.1  E3 ubiquitin-protein ligase TRIP12 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18), as well as variants 19 and 20, encodes the longest isoform (i).
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16662066
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808874
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  18. NM_001348329.1NP_001335258.1  E3 ubiquitin-protein ligase TRIP12 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19), as well as variants 18 and 20, encodes the longest isoform (i).
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16662066
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808874
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  19. NM_001348330.1NP_001335259.1  E3 ubiquitin-protein ligase TRIP12 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20), as well as variants 18 and 19, encodes the longest isoform (i).
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16662066
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808874
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  20. NM_001348331.1NP_001335260.1  E3 ubiquitin-protein ligase TRIP12 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21) encodes isoform j.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:15911991
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766804
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  21. NM_001348332.1NP_001335261.1  E3 ubiquitin-protein ligase TRIP12 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (22) encodes isoform k.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16312031
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:779844
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:460685
    Arm_3; Atypical Arm repeat
  22. NM_001348333.1NP_001335262.1  E3 ubiquitin-protein ligase TRIP12 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (23) encodes isoform l.
    Source sequence(s)
    AC009973, AC093384, AC105380
    Conserved Domains (4) summary
    cd00078
    Location:16392039
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808847
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  23. NM_001348334.1NP_001335263.1  E3 ubiquitin-protein ligase TRIP12 isoform n

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26) encodes isoform n.
    Source sequence(s)
    AC009973
  24. NM_001348335.1NP_001335264.1  E3 ubiquitin-protein ligase TRIP12 isoform m

    Status: REVIEWED

    Description
    Transcript Variant: This variant (24), as well as variant 25, encodes isoform m.
    Source sequence(s)
    AC009973
  25. NM_001348336.1NP_001335265.1  E3 ubiquitin-protein ligase TRIP12 isoform m

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variant 24, encodes isoform m.
    Source sequence(s)
    AC009973
    Related
    ENSP00000386388.1, ENST00000409677.5
  26. NM_004238.2NP_004229.1  E3 ubiquitin-protein ligase TRIP12 isoform c

    See identical proteins and their annotated locations for NP_004229.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) encodes isoform c.
    Source sequence(s)
    AC093384, BM677880, D28476, DB240964
    Consensus CDS
    CCDS33391.1
    UniProtKB/Swiss-Prot
    Q14669
    Related
    ENSP00000283943.4, OTTHUMP00000204207, ENST00000283943.9, OTTHUMT00000331861
    Conserved Domains (3) summary
    smart00119
    Location:16081986
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:15901990
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:760798
    WWE; WWE domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    229763837..229923234 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453223.1XP_024308991.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    Conserved Domains (4) summary
    cd00078
    Location:16902090
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808874
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  2. XM_024453243.1XP_024309011.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

    Conserved Domains (4) summary
    cd00078
    Location:15961996
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766804
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  3. XM_024453239.1XP_024309007.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

    Conserved Domains (4) summary
    cd00078
    Location:16482048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766832
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  4. XM_024453228.1XP_024308996.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    Conserved Domains (4) summary
    cd00078
    Location:16902090
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808874
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  5. XM_024453226.1XP_024308994.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    Conserved Domains (4) summary
    cd00078
    Location:16902090
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808874
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  6. XM_017005290.2XP_016860779.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

  7. XM_017005289.2XP_016860778.1  E3 ubiquitin-protein ligase TRIP12 isoform X11

  8. XM_024453233.1XP_024309001.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

    Conserved Domains (4) summary
    cd00078
    Location:16612061
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:779845
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:460685
    Arm_3; Atypical Arm repeat
  9. XM_017005283.2XP_016860772.1  E3 ubiquitin-protein ligase TRIP12 isoform X8

  10. XM_024453232.1XP_024309000.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

    Conserved Domains (4) summary
    cd00078
    Location:16622062
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808846
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  11. XM_024453229.1XP_024308997.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

    Conserved Domains (4) summary
    cd00078
    Location:16892089
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808873
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  12. XM_024453231.1XP_024308999.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

    Conserved Domains (4) summary
    cd00078
    Location:16632063
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808847
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  13. XM_024453242.1XP_024309010.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

    Conserved Domains (4) summary
    cd00078
    Location:16192019
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:737803
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:418643
    Arm_3; Atypical Arm repeat
  14. XM_024453241.1XP_024309009.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

    Conserved Domains (4) summary
    cd00078
    Location:16472047
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766831
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  15. XM_024453236.1XP_024309004.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

    Conserved Domains (4) summary
    cd00078
    Location:16482048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766832
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  16. XM_005246961.4XP_005247018.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

    See identical proteins and their annotated locations for XP_005247018.1

    Conserved Domains (3) summary
    smart00119
    Location:16422020
    HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
    cd00078
    Location:16242024
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766832
    WWE; WWE domain
  17. XM_024453234.1XP_024309002.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

    Conserved Domains (4) summary
    cd00078
    Location:16612061
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:779845
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:460685
    Arm_3; Atypical Arm repeat
  18. XM_024453224.1XP_024308992.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    Conserved Domains (4) summary
    cd00078
    Location:16902090
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808874
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  19. XM_024453230.1XP_024308998.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

    Conserved Domains (4) summary
    cd00078
    Location:16892089
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808873
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  20. XM_024453237.1XP_024309005.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

    Conserved Domains (4) summary
    cd00078
    Location:16482048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766832
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  21. XM_024453225.1XP_024308993.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    Conserved Domains (4) summary
    cd00078
    Location:16902090
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808874
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
  22. XM_024453238.1XP_024309006.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

    Conserved Domains (4) summary
    cd00078
    Location:16482048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766832
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  23. XM_024453240.1XP_024309008.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

    Conserved Domains (4) summary
    cd00078
    Location:16482048
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:766832
    WWE; WWE domain
    pfam10500
    Location:57191
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:447672
    Arm_3; Atypical Arm repeat
  24. XM_024453235.1XP_024309003.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

    Conserved Domains (4) summary
    cd00078
    Location:16612061
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:779845
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:460685
    Arm_3; Atypical Arm repeat
  25. XM_024453227.1XP_024308995.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    Conserved Domains (4) summary
    cd00078
    Location:16902090
    HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    pfam02825
    Location:808874
    WWE; WWE domain
    pfam10500
    Location:99233
    SR-25; Nuclear RNA-splicing-associated protein
    cl25709
    Location:489714
    Arm_3; Atypical Arm repeat
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