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NEURL3 neuralized E3 ubiquitin protein ligase 3 [ Homo sapiens (human) ]

Gene ID: 93082, updated on 10-Oct-2019

Summary

Official Symbol
NEURL3provided by HGNC
Official Full Name
neuralized E3 ubiquitin protein ligase 3provided by HGNC
Primary source
HGNC:HGNC:25162
See related
Ensembl:ENSG00000163121 MIM:617206
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LINCR; RNF132
Expression
Biased expression in salivary gland (RPKM 4.9), kidney (RPKM 1.8) and 5 other tissues See more
Orthologs

Genomic context

See NEURL3 in Genome Data Viewer
Location:
2q11.2
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (96497643..96508157, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (97163383..97173846, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ITPRIP like 1 Neighboring gene non-SMC condensin I complex subunit H Neighboring gene uncharacterized LOC105373496 Neighboring gene AT-rich interaction domain 5A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
E3 ubiquitin-protein ligase NEURL3
Names
RING-type E3 ubiquitin transferase NEURL3
lung-inducible neuralized-related C3CH4 RING domain protein
neuralized homolog 3 pseudogene
neuralized-like protein 3
NP_001272414.1
NP_001272415.1
XP_011510480.1
XP_011510481.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001285485.2NP_001272414.1  E3 ubiquitin-protein ligase NEURL3 isoform a

    See identical proteins and their annotated locations for NP_001272414.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shortest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC013270, CA311039, DC406186, HY288910
    Consensus CDS
    CCDS74542.1
    UniProtKB/Swiss-Prot
    Q96EH8
    Related
    ENSP00000478591.1, ENST00000451794.6
    Conserved Domains (4) summary
    smart00588
    Location:16138
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:2085
    Neuralized; Neuralized
    pfam13920
    Location:200247
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:19171
    SPRY; SPRY domain
  2. NM_001285486.2NP_001272415.1  E3 ubiquitin-protein ligase NEURL3 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains two alternate exons, one of which results in a frameshift, compared to variant 1. The resulting protein (isoform b) uses a downstream, in-frame AUG and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AL389981, DC406186
    Consensus CDS
    CCDS74541.1
    UniProtKB/TrEMBL
    A0A087WVI2
    Related
    ENSP00000479456.1, ENST00000310865.7

RNA

  1. NR_104346.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC012317, CA311039
    Related
    ENST00000435380.3

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    96497643..96508157 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512179.2XP_011510481.1  E3 ubiquitin-protein ligase NEURL3 isoform X1

    See identical proteins and their annotated locations for XP_011510481.1

    UniProtKB/Swiss-Prot
    Q96EH8
    Conserved Domains (4) summary
    smart00588
    Location:16138
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:2085
    Neuralized; Neuralized
    pfam13920
    Location:200247
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:19171
    SPRY; SPRY domain
  2. XM_011512178.2XP_011510480.1  E3 ubiquitin-protein ligase NEURL3 isoform X1

    See identical proteins and their annotated locations for XP_011510480.1

    UniProtKB/Swiss-Prot
    Q96EH8
    Conserved Domains (4) summary
    smart00588
    Location:16138
    NEUZ; domain in neuralized proteins
    pfam07177
    Location:2085
    Neuralized; Neuralized
    pfam13920
    Location:200247
    zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)
    cl02614
    Location:19171
    SPRY; SPRY domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001080535.1: Suppressed sequence

    Description
    NM_001080535.1: This RefSeq was permanently suppressed because insufficient support for the specific combination of exons in the RefSeq record and the protein currently exists.
  2. NR_026875.1: Suppressed sequence

    Description
    NR_026875.1: This RefSeq was permanently suppressed because it is now thought that this gene does encode a protein.
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