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TAAR2 trace amine associated receptor 2 [ Homo sapiens (human) ]

Gene ID: 9287, updated on 22-Sep-2022

Summary

Official Symbol
TAAR2provided by HGNC
Official Full Name
trace amine associated receptor 2provided by HGNC
Primary source
HGNC:HGNC:4514
See related
Ensembl:ENSG00000146378 MIM:604849; AllianceGenome:HGNC:4514
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GPR58; taR-2
Summary
Predicted to enable trace-amine receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See TAAR2 in Genome Data Viewer
Location:
6q23.2
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (132617150..132624275, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (133812108..133819243, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (132938289..132945414, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene trace amine associated receptor 5 Neighboring gene trace amine associated receptor 4, pseudogene Neighboring gene trace amine associated receptor 3, pseudogene Neighboring gene trace amine associated receptor 1 Neighboring gene HLF pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables trace-amine receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
trace amine-associated receptor 2
Names
G protein-coupled receptor 58

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033080.1NP_001028252.1  trace amine-associated receptor 2 isoform 1

    See identical proteins and their annotated locations for NP_001028252.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AY703480
    Consensus CDS
    CCDS34541.1
    UniProtKB/Swiss-Prot
    Q6NWS3, Q9P1P5
    Related
    ENSP00000356908.1, ENST00000367931.1
    Conserved Domains (2) summary
    pfam00001
    Location:60315
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:53180
    7tm_4; Olfactory receptor
  2. NM_014626.3NP_055441.2  trace amine-associated receptor 2 isoform 2

    See identical proteins and their annotated locations for NP_055441.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks part of the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    AY702304, DN693314
    Consensus CDS
    CCDS5157.1
    UniProtKB/Swiss-Prot
    Q9P1P5
    Related
    ENSP00000275191.2, ENST00000275191.2
    Conserved Domains (2) summary
    pfam00001
    Location:15270
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:8135
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    132617150..132624275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    133812108..133819243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)