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GPR37L1 G protein-coupled receptor 37 like 1 [ Homo sapiens (human) ]

Gene ID: 9283, updated on 20-May-2018
Official Symbol
GPR37L1provided by HGNC
Official Full Name
G protein-coupled receptor 37 like 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000170075 MIM:617630; Vega:OTTHUMG00000035924
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Biased expression in brain (RPKM 18.1) and colon (RPKM 0.5) See more
See GPR37L1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (202118669..202133588)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (202092029..202098634)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene FOXA motif-containing MPRA enhancer 200 Neighboring gene uncharacterized LOC105371684 Neighboring gene cysteine rich protein 1 pseudogene 3 Neighboring gene uncharacterized LOC105371683 Neighboring gene ADP ribosylation factor like GTPase 8A Neighboring gene protein tyrosine phosphatase, non-receptor type 7 Neighboring gene protein tyrosine phosphatase, receptor type V, pseudogene

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), (originally at The groupings are based on the GPCR phylogenetic tree available fr...
  • Peptide ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Peptide ligand-binding receptors, organism-specific biosystemThese receptors, a subset of the Class A/1 (Rhodopsin-like) family, all bind peptide ligands which include the chemokines, opioids and somatostatins.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...



Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled peptide receptor activity IDA
Inferred from Direct Assay
more info
peptide binding IPI
Inferred from Physical Interaction
more info
prosaposin receptor activity IDA
Inferred from Direct Assay
more info
protein binding IPI
Inferred from Physical Interaction
more info
Component Evidence Code Pubs
integral component of membrane NAS
Non-traceable Author Statement
more info
plasma membrane TAS
Traceable Author Statement
more info
receptor complex IDA
Inferred from Direct Assay
more info
Preferred Names
prosaposin receptor GPR37L1
endothelin B receptor-like protein 2
endothelin type b receptor-like protein 2

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004767.4NP_004758.3  prosaposin receptor GPR37L1 precursor

    See identical proteins and their annotated locations for NP_004758.3

    Status: VALIDATED

    Source sequence(s)
    AK222639, AL050068, AL592300
    Consensus CDS
    ENSP00000356251.4, OTTHUMP00000034103, ENST00000367282.5
    Conserved Domains (1) summary
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly


  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510158.2XP_011508460.1  prosaposin receptor GPR37L1 isoform X1

    Conserved Domains (1) summary
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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