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CYTH2 cytohesin 2 [ Homo sapiens (human) ]

Gene ID: 9266, updated on 7-Dec-2018

Summary

Official Symbol
CYTH2provided by HGNC
Official Full Name
cytohesin 2provided by HGNC
Primary source
HGNC:HGNC:9502
See related
Ensembl:ENSG00000105443 MIM:602488
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARNO; CTS18; PSCD2; SEC7L; PSCD2L; CTS18.1; Sec7p-L; Sec7p-like; cytohesin-2
Summary
The protein encoded by this gene is a member of the PSCD family. Members of this family have identical structural organization that consists of an N-terminal coiled-coil motif, a central Sec7 domain, and a C-terminal pleckstrin homology (PH) domain. The coiled-coil motif is involved in homodimerization, the Sec7 domain contains guanine-nucleotide exchange protein (GEP) activity, and the PH domain interacts with phospholipids and is responsible for association of PSCDs with membranes. Members of this family appear to mediate the regulation of protein sorting and membrane trafficking. The encoded protein exhibits GEP activity in vitro with ARF1, ARF3, and ARF6 and is 83% homologous to CYTH1. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Expression
Ubiquitous expression in testis (RPKM 10.9), thyroid (RPKM 9.4) and 25 other tissues See more
Orthologs

Genomic context

See CYTH2 in Genome Data Viewer
Location:
19q13.33
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (48469208..48482314)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48972465..48985571)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene glutamate rich WD repeat containing 1 Neighboring gene uncharacterized LOC105372430 Neighboring gene potassium voltage-gated channel subfamily J member 14 Neighboring gene lemur tyrosine kinase 3 Neighboring gene sulfotransferase family 2B member 1 Neighboring gene Sharpr-MPRA regulatory regions 10218 and 12364

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Arf1 pathway, organism-specific biosystem (from Pathway Interaction Database)
    Arf1 pathway, organism-specific biosystem
    Arf1 pathway
  • Arf6 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Arf6 signaling events, organism-specific biosystem
    Arf6 signaling events
  • Class I PI3K signaling events, organism-specific biosystem (from Pathway Interaction Database)
    Class I PI3K signaling events, organism-specific biosystem
    Class I PI3K signaling events
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi and retrograde Golgi-to-ER traffic, organism-specific biosystemThe mammalian Golgi complex, a central hub of both anterograde and retrograde trafficking, is a ribbon of stacked cisterna with biochemically distinct compartments (reviewed in Glick and Nakano, 2009...
  • Intra-Golgi traffic, organism-specific biosystem (from REACTOME)
    Intra-Golgi traffic, organism-specific biosystemThe mammalian Golgi consists of at least three biochemically distinct cisternae, cis-, medial- and trans (reviewed in Szul and Sztul, 2011; Day et al, 2013). The structure and function of the Golgi a...
  • Membrane Trafficking, organism-specific biosystem (from REACTOME)
    Membrane Trafficking, organism-specific biosystemThe secretory membrane system allows a cell to regulate delivery of newly synthesized proteins, carbohydrates, and lipids to the cell surface, a necessity for growth and homeostasis. The system is ma...
  • Phospholipase D signaling pathway, organism-specific biosystem (from KEGG)
    Phospholipase D signaling pathway, organism-specific biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Phospholipase D signaling pathway, conserved biosystem (from KEGG)
    Phospholipase D signaling pathway, conserved biosystemPhospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membra...
  • Vesicle-mediated transport, organism-specific biosystem (from REACTOME)
    Vesicle-mediated transport, organism-specific biosystemThe transit of proteins and other cargo through the cell requires a cellular transport process in which transported substances are moved in membrane-bounded vesicles. Transported substances are enclo...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ARF guanyl-nucleotide exchange factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
inositol 1,4,5 trisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
actin cytoskeleton organization TAS
Traceable Author Statement
more info
PubMed 
endocytosis TAS
Traceable Author Statement
more info
PubMed 
regulation of ARF protein signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi membrane TAS
Traceable Author Statement
more info
 
adherens junction IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
growth cone IEA
Inferred from Electronic Annotation
more info
 
membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytohesin-2
Names
ARF exchange factor
ARF nucleotide-binding site opener
CTC-273B12.8
PH, SEC7 and coiled-coil domain-containing protein 2
pleckstrin homology, Sec7 and coiled-coil domains 2
pleckstrin homology, Sec7 and coiled/coil domains 2 (cytohesin-2)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004228.7NP_004219.3  cytohesin-2 isoform 2

    See identical proteins and their annotated locations for NP_004219.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks a 3-nucleotide exon in the PH domain region, compared to variant 1. This results in a protein (isoform 2) missing a single glycine residue, compared to isoform 1.
    Source sequence(s)
    AC008403, BC012771, DC344850, X99753
    Consensus CDS
    CCDS12722.1
    UniProtKB/Swiss-Prot
    Q99418
    Related
    ENSP00000408236.2, ENST00000452733.6
    Conserved Domains (2) summary
    cd01252
    Location:258377
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:61243
    Sec7; Sec7 domain
  2. NM_017457.5NP_059431.1  cytohesin-2 isoform 1

    See identical proteins and their annotated locations for NP_059431.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC008403, BC012771, BC038713, DC344850
    Consensus CDS
    CCDS86786.1
    UniProtKB/Swiss-Prot
    Q99418
    Related
    ENSP00000493357.1, ENST00000641098.1
    Conserved Domains (2) summary
    cd01252
    Location:258378
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam01369
    Location:61243
    Sec7; Sec7 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    48469208..48482314
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723472.2XP_006723535.1  cytohesin-2 isoform X1

    Conserved Domains (4) summary
    cd01252
    Location:280399
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam00169
    Location:284397
    PH; PH domain
    pfam01369
    Location:83265
    Sec7; Sec7 domain
    cl19219
    Location:21109
    DUF342; Protein of unknown function (DUF342)
  2. XM_006723473.2XP_006723536.1  cytohesin-2 isoform X2

    Conserved Domains (4) summary
    cd01252
    Location:280394
    PH_GRP1-like; General Receptor for Phosphoinositides-1-like Pleckstrin homology (PH) domain
    pfam00169
    Location:284394
    PH; PH domain
    pfam01369
    Location:83265
    Sec7; Sec7 domain
    cl19219
    Location:21109
    DUF342; Protein of unknown function (DUF342)

RNA

  1. XR_001753792.2 RNA Sequence

    Related
    ENST00000493260.5
  2. XR_001753791.1 RNA Sequence

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