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TSPOAP1 TSPO associated protein 1 [ Homo sapiens (human) ]

Gene ID: 9256, updated on 21-Dec-2019

Summary

Official Symbol
TSPOAP1provided by HGNC
Official Full Name
TSPO associated protein 1provided by HGNC
Primary source
HGNC:HGNC:16831
See related
Ensembl:ENSG00000005379 MIM:610764
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PRAX1; BZRAP1; PBR-IP; PRAX-1; RIMBP1; RIM-BP1
Expression
Broad expression in brain (RPKM 13.4), bone marrow (RPKM 7.4) and 23 other tissues See more
Orthologs

Genomic context

See TSPOAP1 in Genome Data Viewer
Location:
17q22
Exon count:
32
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (58301231..58328795, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (56378588..56406152, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene MPO proximal enhancer and promoter region Neighboring gene myeloperoxidase Neighboring gene MPO upstream enhancer region Neighboring gene Sharpr-MPRA regulatory region 10051 Neighboring gene TSPOAP1, SUPT4H1 and RNF43 antisense RNA 1 Neighboring gene microRNA 142 Neighboring gene microRNA 4736

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0612, DKFZp686F02123

Gene Ontology Provided by GOA

Function Evidence Code Pubs
benzodiazepine receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
benzodiazepine receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
C21-steroid hormone biosynthetic process TAS
Traceable Author Statement
more info
 
biological_process ND
No biological Data available
more info
 
glutamate secretion TAS
Traceable Author Statement
more info
 
NOT neuromuscular synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter secretion TAS
Traceable Author Statement
more info
 
regulation of presynaptic cytosolic calcium ion concentration IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
calyx of Held IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peripheral-type benzodiazepine receptor-associated protein 1
Names
RIMS-binding protein 1
benzodiazapine receptor peripheral-associated protein 1
benzodiazepine receptor (peripheral) associated protein 1
peripheral benzodiazepine receptor-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001261835.2NP_001248764.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform c

    See identical proteins and their annotated locations for NP_001248764.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (c) is shorter than isoform a.
    Source sequence(s)
    AB014512, AC004687, AF039571, AI811889, BC150279, BC171787, BE246483, BF934025
    UniProtKB/Swiss-Prot
    O95153
    UniProtKB/TrEMBL
    A7E2C5, B7ZVZ7, X5DQQ3
    Conserved Domains (6) summary
    cd12012
    Location:16291690
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:17591819
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:657717
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:885947
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12718
    Location:350507
    Tropomyosin_1; Tropomyosin like
    cl02488
    Location:332524
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  2. NM_004758.4NP_004749.2  peripheral-type benzodiazepine receptor-associated protein 1 isoform a

    See identical proteins and their annotated locations for NP_004749.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AB014512, AC004687, AF039571, AI811889, BC146852, BC150279, BC171787, BE246483
    Consensus CDS
    CCDS11605.1
    UniProtKB/Swiss-Prot
    O95153
    UniProtKB/TrEMBL
    A7E2C5, B2RUT8, B7ZVZ7
    Related
    ENSP00000345824.4, ENST00000343736.9
    Conserved Domains (6) summary
    cd12012
    Location:16291690
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:17681828
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:657717
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:885947
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12718
    Location:350507
    Tropomyosin_1; Tropomyosin like
    cl02488
    Location:332524
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
  3. NM_024418.3NP_077729.1  peripheral-type benzodiazepine receptor-associated protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (b) is shorter than isoform a.
    Source sequence(s)
    AB014512, AC004687, AF039571, AI811889, BC146852, BC171787, BE246483
    Consensus CDS
    CCDS45742.1
    UniProtKB/Swiss-Prot
    O95153
    UniProtKB/TrEMBL
    B2RUT8, B7ZVZ7
    Related
    ENSP00000268893.6, ENST00000268893.10
    Conserved Domains (7) summary
    cd12012
    Location:15691630
    SH3_RIM-BP_2; Second Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12013
    Location:17081768
    SH3_RIM-BP_3; Third Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd12014
    Location:597657
    SH3_RIM-BP_1; First Src homology 3 domain of Rab3-interacting molecules (RIMs) binding proteins
    cd00063
    Location:825887
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam12718
    Location:290447
    Tropomyosin_1; Tropomyosin like
    pfam15619
    Location:125332
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl02488
    Location:272464
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    58301231..58328795 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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