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GPR50 G protein-coupled receptor 50 [ Homo sapiens (human) ]

Gene ID: 9248, updated on 3-Jun-2018
Official Symbol
GPR50provided by HGNC
Official Full Name
G protein-coupled receptor 50provided by HGNC
Primary source
HGNC:HGNC:4506
See related
Ensembl:ENSG00000102195 MIM:300207; Vega:OTTHUMG00000024166
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H9; Mel1c
Summary
This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
Expression
Low expression observed in reference dataset See more
Orthologs
See GPR50 in Genome Data Viewer
Location:
Xq28
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) X NC_000023.11 (151176584..151182855)
105 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (150345056..150349937)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 525 Neighboring gene microRNA 4330 Neighboring gene GPR50 antisense RNA 1 Neighboring gene NGFI-A binding protein 1 (EGR1 binding protein 1) pseudogene Neighboring gene VISTA enhancer hs1746

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC125342, AF003625.3

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
melatonin receptor activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016405.1 RefSeqGene

    Range
    5001..9882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004224.3NP_004215.2  melatonin-related receptor

    See identical proteins and their annotated locations for NP_004215.2

    Status: REVIEWED

    Source sequence(s)
    BC105683, BC105684, BP245442, U52219
    Consensus CDS
    CCDS44012.1
    UniProtKB/Swiss-Prot
    Q13585
    Related
    ENSP00000218316.3, OTTHUMP00000025869, ENST00000218316.3, OTTHUMT00000060874
    Conserved Domains (3) summary
    pfam00001
    Location:45294
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    pfam13254
    Location:364600
    DUF4045; Domain of unknown function (DUF4045)
    cl21561
    Location:39198
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p12 Primary Assembly

    Range
    151176584..151182855
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531216.2XP_011529518.1  melatonin-related receptor isoform X1

    Conserved Domains (2) summary
    PRK14950
    Location:261344
    PRK14950; DNA polymerase III subunits gamma and tau; Provisional
    pfam00001
    Location:247
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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