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CRB3 crumbs cell polarity complex component 3 [ Homo sapiens (human) ]

Gene ID: 92359, updated on 1-Jun-2020

Summary

Official Symbol
CRB3provided by HGNC
Official Full Name
crumbs cell polarity complex component 3provided by HGNC
Primary source
HGNC:HGNC:20237
See related
Ensembl:ENSG00000130545 MIM:609737
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2016]
Expression
Broad expression in colon (RPKM 9.7), duodenum (RPKM 9.6) and 16 other tissues See more
Orthologs

Genomic context

See CRB3 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (6463777..6467221)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (6463788..6467232)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene KH-type splicing regulatory protein Neighboring gene microRNA 3940 Neighboring gene solute carrier family 25 member 41 Neighboring gene solute carrier family 25 member 23 Neighboring gene DENN domain containing 1C Neighboring gene tubulin beta 4A class IVa Neighboring gene CRISPRi-validated cis-regulatory element chr19.1358

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SH3 domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
bicellular tight junction assembly TAS
Traceable Author Statement
more info
 
protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
apical plasma membrane IEA
Inferred from Electronic Annotation
more info
 
bicellular tight junction IEA
Inferred from Electronic Annotation
more info
 
cell junction IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
protein-containing complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
protein crumbs homolog 3
Names
crumbs 3, cell polarity complex component
crumbs family member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029879.1 RefSeqGene

    Range
    5023..7973
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139161.5NP_631900.1  protein crumbs homolog 3 isoform a precursor

    See identical proteins and their annotated locations for NP_631900.1

    Status: REVIEWED

    Source sequence(s)
    AF503290, BC002652, DB215367
    Consensus CDS
    CCDS12167.1
    UniProtKB/Swiss-Prot
    Q9BUF7
    Related
    ENSP00000472010.1, ENST00000600229.6
  2. NM_174881.4NP_777377.1  protein crumbs homolog 3 isoform b precursor

    See identical proteins and their annotated locations for NP_777377.1

    Status: REVIEWED

    Source sequence(s)
    AY358684, BC002652, DB215367
    Consensus CDS
    CCDS12166.1
    UniProtKB/Swiss-Prot
    Q9BUF7
    Related
    ENSP00000349204.2, ENST00000356762.7
  3. NM_174882.2NP_777378.1  protein crumbs homolog 3 isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AY103469, BC002652, BC018409
    UniProtKB/Swiss-Prot
    Q9BUF7
    Related
    ENSP00000469707.1, ENST00000598494.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    6463777..6467221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027471.1XP_016882960.1  protein crumbs homolog 3 isoform X1

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